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- Schiller, D, et al.
(author)
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The Human Affectome
- 2024
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In: Neuroscience and biobehavioral reviews. - 1873-7528. ; 158, s. 105450-
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Journal article (peer-reviewed)
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| 3. |
- Forstner, A. J., et al.
(author)
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Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression
- 2021
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26
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Journal article (peer-reviewed)abstract
- Panic disorder (PD) has a lifetime prevalence of 2–4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0–34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10−4 were followed up in an independent sample of 2408 PD patients and 228,470 controls from Denmark, Iceland and the Netherlands. In the combined analysis, SNP rs144783209 showed the strongest association with PD (pcomb = 3.10 × 10−7). Sign tests revealed a significant enrichment of SNPs with a discovery p-value of <0.0001 in the combined follow up cohort (p = 0.048). The present integrative analysis represents a major step towards the elucidation of the genetic susceptibility to PD. © 2019, The Author(s), under exclusive licence to Springer Nature Limited.
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| 5. |
- Rayner, C, et al.
(author)
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A genome-wide association meta-analysis of prognostic outcomes following cognitive behavioural therapy in individuals with anxiety and depressive disorders
- 2019
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In: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 9:1, s. 150-
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Journal article (peer-reviewed)abstract
- Major depressive disorder and the anxiety disorders are highly prevalent, disabling and moderately heritable. Depression and anxiety are also highly comorbid and have a strong genetic correlation (rg ≈ 1). Cognitive behavioural therapy is a leading evidence-based treatment but has variable outcomes. Currently, there are no strong predictors of outcome. Therapygenetics research aims to identify genetic predictors of prognosis following therapy. We performed genome-wide association meta-analyses of symptoms following cognitive behavioural therapy in adults with anxiety disorders (n = 972), adults with major depressive disorder (n = 832) and children with anxiety disorders (n = 920; meta-analysis n = 2724). We estimated the variance in therapy outcomes that could be explained by common genetic variants (h2SNP) and polygenic scoring was used to examine genetic associations between therapy outcomes and psychopathology, personality and learning. No single nucleotide polymorphisms were strongly associated with treatment outcomes. No significant estimate of h2SNP could be obtained, suggesting the heritability of therapy outcome is smaller than our analysis was powered to detect. Polygenic scoring failed to detect genetic overlap between therapy outcome and psychopathology, personality or learning. This study is the largest therapygenetics study to date. Results are consistent with previous, similarly powered genome-wide association studies of complex traits.
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- Pajola, M., et al.
(author)
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The Agilkia boulders/pebbles size-frequency distributions : OSIRIS and ROLIS joint observations of 67P surface
- 2016
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In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 462, s. S242-S252
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Journal article (peer-reviewed)abstract
- By using the images acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) and ROLIS (ROsetta Lander Imaging System) cameras, we derive the size-frequency distribution (SFD) of cometary pebbles and boulders covering the size range 0.05-30.0 m on the Agilkia landing site. The global SFD measured on OSIRIS images, reflects the different properties of the multiple morphological units present on Agilkia, combined with selection effects related to lifting, transport and redeposition. Contrarily, the different ROLIS SFD derived on the smooth and rough units may be related to their different regolith thickness present on Agilkia. In the thicker, smoother layer, ROLIS mainly measures the SFD of the airfall population which almost completely obliterates the signature of underlying boulders up to a size of the order of 1 m. This is well matched by the power-law index derived analysing coma particles identified by the grain analyser Grain Impact Analyser and Dust Accumulator. This result confirms the important blanketing dynamism of Agilkia. The steeper SFD observed in rough terrains from 0.4 to 2 m could point out intrinsic differences between northern and southern dust size distributions, or it may suggest that the underlying boulders 'peek through' the thinner airfall layer in the rough terrain, thereby producing the observed excess in the decimetre size range. Eventually, the OSIRIS SFD performed on the Philae landing unit may be due to water sublimation from a static population of boulders, affecting smaller boulders before the bigger ones, thus shallowing the original SFD.
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