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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake

Williamson, Alice (author)
University of Cambridge
Norris, Dougall M (author)
Yin, Xianyong (author)
show more...
Broadaway, K Alaine (author)
Moxley, Anne H (author)
Vadlamudi, Swarooparani (author)
Wilson, Emma P (author)
Jackson, Anne U (author)
Ahuja, Vasudha (author)
Andersen, Mette K (author)
Arzumanyan, Zorayr (author)
Bonnycastle, Lori L (author)
Bornstein, Stefan R (author)
Bretschneider, Maxi P (author)
Buchanan, Thomas A (author)
Chang, Yi-Cheng (author)
Chuang, Lee-Ming (author)
Chung, Ren-Hua (author)
Clausen, Tine D (author)
Damm, Peter (author)
Delgado, Graciela E (author)
de Mello, Vanessa D (author)
Dupuis, Josée (author)
Dwivedi, Om P (author)
Erdos, Michael R (author)
Silva, Lilian Fernandes (author)
Frayling, Timothy M (author)
Gieger, Christian (author)
Goodarzi, Mark O (author)
Guo, Xiuqing (author)
Gustafsson, Stefan (author)
Uppsala universitet,Klinisk epidemiologi
Hakaste, Liisa (author)
Hammar, Ulf (author)
Uppsala universitet,Molekylär epidemiologi
Hatem, G. (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Herrmann, Sandra (author)
Højlund, Kurt (author)
Horn, Katrin (author)
Hsueh, Willa A (author)
Hung, Yi-Jen (author)
Hwu, Chii-Min (author)
Jonsson, Anna (author)
Kårhus, Line L (author)
Kleber, Marcus E (author)
Kovacs, Peter (author)
Lakka, Timo A (author)
Lauzon, Marie (author)
Lee, I-Te (author)
Lindgren, Cecilia M (author)
Lindström, Jaana (author)
Linneberg, Allan (author)
Liu, Ching-Ti (author)
Luan, Jian'an (author)
Aly, D.M. (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Mathiesen, Elisabeth (author)
Moissl, Angela P (author)
Morris, Andrew P (author)
Narisu, Narisu (author)
Perakakis, Nikolaos (author)
Peters, Annette (author)
Prasad, R.B. (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
Rodionov, Roman N (author)
Roll, Kathryn (author)
Rundsten, Carsten F (author)
Sarnowski, Chloé (author)
Savonen, Kai (author)
Scholz, Markus (author)
Sharma, Sapna (author)
Stinson, Sara E (author)
Suleman, Sufyan (author)
Tan, Jingyi (author)
Taylor, Kent D (author)
Uusitupa, Matti (author)
Vistisen, Dorte (author)
Witte, Daniel R (author)
Walther, Romy (author)
Wu, Peitao (author)
Xiang, Anny H (author)
Zethelius, Björn (author)
Uppsala universitet,Geriatrik
Ahlqvist, E. (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Bergman, Richard N (author)
Chen, Yii-Der Ida (author)
Collins, Francis S (author)
Fall, Tove, 1979- (author)
Uppsala universitet,Molekylär epidemiologi
Florez, Jose C (author)
Fritsche, Andreas (author)
Grallert, Harald (author)
Groop, L. (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
Hansen, Torben (author)
Koistinen, Heikki A (author)
Komulainen, Pirjo (author)
Laakso, Markku (author)
Lind, Lars (author)
Uppsala universitet,Klinisk epidemiologi
Loeffler, Markus (author)
März, Winfried (author)
Meigs, James B (author)
Lund University,University Hospital of Tubingen,Massachusetts General Hospital
Raffel, Leslie J (author)
Rauramaa, Rainer (author)
Rotter, Jerome I (author)
Schwarz, Peter E H (author)
Stumvoll, Michael (author)
Sundström, Johan, Professor, 1971- (author)
Uppsala universitet,Klinisk epidemiologi
Tönjes, Anke (author)
Tuomi, Tiinamaija (author)
Tuomilehto, Jaakko (author)
Wagner, Robert (author)
Barroso, Inês (author)
Walker, Mark (author)
Grarup, Niels (author)
Boehnke, Michael (author)
Wareham, Nicholas J (author)
Mohlke, Karen L (author)
Wheeler, Eleanor (author)
O'Rahilly, Stephen (author)
Fazakerley, Daniel J (author)
Langenberg, Claudia (author)
Queen Mary University,University of Cambridge,Berlin Institute of Health (BIH),Charité - University Medicine Berlin
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 (creator_code:org_t)
et al 
Springer Nature, 2023
2023
English.
In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:6, s. 973-983
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Blood Glucose
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Glucose
Humans
Insulin
Insulin Resistance
glucose
glucose transporter 4
insulin
adipocyte
ancestry group
Article
body mass
cell culture
controlled study
gene expression
gene identification
genetic variability
genome-wide association study
glucose transport
human
insulin level
insulin resistance
meta analysis (topic)
non insulin dependent diabetes mellitus
transcription regulation
genetics
glucose blood level
metabolism

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Williamson, Alic ...
Norris, Dougall ...
Yin, Xianyong
Broadaway, K Ala ...
Moxley, Anne H
Vadlamudi, Swaro ...
show more...
Wilson, Emma P
Jackson, Anne U
Ahuja, Vasudha
Andersen, Mette ...
Arzumanyan, Zora ...
Bonnycastle, Lor ...
Bornstein, Stefa ...
Bretschneider, M ...
Buchanan, Thomas ...
Chang, Yi-Cheng
Chuang, Lee-Ming
Chung, Ren-Hua
Clausen, Tine D
Damm, Peter
Delgado, Graciel ...
de Mello, Vaness ...
Dupuis, Josée
Dwivedi, Om P
Erdos, Michael R
Silva, Lilian Fe ...
Frayling, Timoth ...
Gieger, Christia ...
Goodarzi, Mark O
Guo, Xiuqing
Gustafsson, Stef ...
Hakaste, Liisa
Hammar, Ulf
Hatem, G.
Herrmann, Sandra
Højlund, Kurt
Horn, Katrin
Hsueh, Willa A
Hung, Yi-Jen
Hwu, Chii-Min
Jonsson, Anna
Kårhus, Line L
Kleber, Marcus E
Kovacs, Peter
Lakka, Timo A
Lauzon, Marie
Lee, I-Te
Lindgren, Cecili ...
Lindström, Jaana
Linneberg, Allan
Liu, Ching-Ti
Luan, Jian'an
Aly, D.M.
Mathiesen, Elisa ...
Moissl, Angela P
Morris, Andrew P
Narisu, Narisu
Perakakis, Nikol ...
Peters, Annette
Prasad, R.B.
Rodionov, Roman ...
Roll, Kathryn
Rundsten, Carste ...
Sarnowski, Chloé
Savonen, Kai
Scholz, Markus
Sharma, Sapna
Stinson, Sara E
Suleman, Sufyan
Tan, Jingyi
Taylor, Kent D
Uusitupa, Matti
Vistisen, Dorte
Witte, Daniel R
Walther, Romy
Wu, Peitao
Xiang, Anny H
Zethelius, Björn
Ahlqvist, E.
Bergman, Richard ...
Chen, Yii-Der Id ...
Collins, Francis ...
Fall, Tove, 1979 ...
Florez, Jose C
Fritsche, Andrea ...
Grallert, Harald
Groop, L.
Hansen, Torben
Koistinen, Heikk ...
Komulainen, Pirj ...
Laakso, Markku
Lind, Lars
Loeffler, Markus
März, Winfried
Meigs, James B
Raffel, Leslie J
Rauramaa, Rainer
Rotter, Jerome I
Schwarz, Peter E ...
Stumvoll, Michae ...
Sundström, Johan ...
Tönjes, Anke
Tuomi, Tiinamaij ...
Tuomilehto, Jaak ...
Wagner, Robert
Barroso, Inês
Walker, Mark
Grarup, Niels
Boehnke, Michael
Wareham, Nichola ...
Mohlke, Karen L
Wheeler, Eleanor
O'Rahilly, Steph ...
Fazakerley, Dani ...
Langenberg, Clau ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
Nature Genetics
By the university
Uppsala University
Lund University

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