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Incidental findings and their handling in the Swedish CArdioPulmonary bioimage study (SCAPIS)

Johnsson, Åse (Allansdotter), 1966 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Radiology, University of Gothenburg, Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
Angerås, Oskar, 1976 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Blomberg, Anders, 1961- (author)
Umeå universitet,Umeå University,Institutionen för folkhälsa och klinisk medicin
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Erlinge, David (author)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
Flinck, Agneta, 1953 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Radiology, University of Gothenburg, Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
Janson, Christer (author)
Uppsala University,Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
Markstad, Hanna (author)
Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Diagnostic Radiology, Lund University and Skåne University Hospital, Lund, Sweden
Persson, Jonas (author)
Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden
Persson, H. Lennart (author)
Linköping University,Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
Swahn, Eva (author)
Linköping University,Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
Torén, Kjell, 1952 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Section of Occupational and Environmental Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Vikgren, Jenny, 1957 (author)
Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Radiology, University of Gothenburg, Gothenburg, Sweden,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
Hansson, Mats G. (author)
Uppsala University,Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden
Bergström, Göran, 1964 (author)
Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory,Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden; The Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, Gothenburg, Sweden
Weckbach, Sabine (editor)
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 (creator_code:org_t)
2016-03-29
2017
English 11 s.
In: Incidental Radiological Findings. - Cham : Springer International Publishing. - 0942-5373 .- 2197-4187. - 9783319425818 - 9783319425795 - 9783319826127 ; , s. 91-101
  • Book chapter (peer-reviewed)
Abstract Subject headings
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  • The Swedish CArdioPulmonary bioImage Study (SCAPIS) combines the use of new imaging technologies, large-scale proteomics/metabolomics/genomics, and epidemiological analyses to extensively characterize a Swedish cohort of 30,000 men and women aged between 50 and 64 years. Its main aims are to improve risk prediction and to optimize our ability to study mechanisms of cardiopulmonary diseases. SCAPIS is currently recruiting at six sites in Sweden, and a pilot study was conducted in 2012 to test the feasibility of the comprehensive study protocol. In the planning phase, it was recognized that the detailed phenotyping used in SCAPIS would identify a large number of clinical findings in need of medical attention. This was confirmed by evaluation of results from the pilot study. Here we focus on pulmonary nodules and asymptomatic coronary artery stenosis. These clinical features were observed in a large number of participants, and the clinical handing and prognosis related to these observations are unclear. They thus posed great challenges for the study in their practical and ethical handling. This chapter describes how we developed procedures to handle these findings based on existing evidence and expert consensus as well as deliberations on ethical issues.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Keyword

Cardiovascular
Epidemiology
Metabolism
Pulmonary
Study design
Cardiovascular

Publication and Content Type

kap (subject category)
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