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Randomised comparis...
Randomised comparison of provisional side branch stenting versus a two-stent strategy for treatment of true coronary bifurcation lesions involving a large side branch : the Nordic-Baltic Bifurcation Study IV
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- Kumsars, Indulis (author)
- Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
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- Holm, Niels Ramsing (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Niemelä, Matti (author)
- Department of Cardiology, Oulu University Hospital, Oulu, Finland
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- Erglis, Andrejs (author)
- Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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- Kervinen, Kari (author)
- Department of Cardiology, Oulu University Hospital, Oulu, Finland
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- Christiansen, Evald Hoj (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Maeng, Michael (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Dombrovskis, Andis (author)
- Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
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- Abraitis, Vytautas (author)
- Department of Cardiology, Vilnius University Hospital, Vilnius, Lithuania
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- Kibarskis, Aleksandras (author)
- Department of Cardiology, Vilnius University Hospital, Vilnius, Lithuania
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- Trovik, Thor (author)
- Department of Cardiology, University of North Norway, Tromsoe, Norway
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- Latkovskis, Gustavs (author)
- Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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- Sondore, Dace (author)
- Department of Cardiology, Latvia Center of Cardiology, Paul Stradins Clinical University Hospital, Riga, Latvia
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- Narbute, Inga (author)
- Research Institute of Cardiology and Regenerative Medicine, Latvia Centre of Cardiology, Riga, Latvia
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- Terkelsen, Christian Juhl (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Eskola, Markku (author)
- Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland
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- Romppanen, Hannu (author)
- Department of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland
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- Laine, Mika (author)
- Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
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- Jensen, Lisette Okkels (author)
- Department of Cardiology, Odense University Hospital, Odense, Denmark
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- Pietila, Mikko (author)
- Department of Cardiology, Turku University Hospital, Turku, Finland
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- Gunnes, Pal (author)
- Heart Center, Sørlandet Hospital, Arendal, Norway
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- Hebsgaard, Lasse (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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- Fröbert, Ole, 1964- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
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- Calais, Fredrik, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiology
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- Hartikainen, Juha (author)
- Department of cardiology, Heart Center, Kuopio University Hospital, Kuopio, Finland
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- Aarøe, Jens (author)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Ravkilde, Jan (author)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Engstrøm, Thomas (author)
- Department of Cardiology, Rigshospitalet, Copenhagen, Denmark
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- Steigen, Terje K. (author)
- Department of Cardiology, University Hospital of North Norway, Tromsoe and Cardiovascular Diseases Research Group, UiT The Arctic University of Norway, Tromsø, Norway
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- Thuesen, Leif (author)
- Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Lassen, Jens F. (author)
- Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
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(creator_code:org_t)
- 2020-01-19
- 2020
- English.
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In: Open heart. - : BMJ Publishing Group Ltd. - 2053-3624. ; 7:1
- Related links:
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https://doi.org/10.1...
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https://openheart.bm...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: It is still uncertain whether coronary bifurcations with lesions involving a large side branch (SB) should be treated by stenting the main vessel and provisional stenting of the SB (simple) or by routine two-stent techniques (complex). We aimed to compare clinical outcome after treatment of lesions in large bifurcations by simple or complex stent implantation.Methods: The study was a randomised, superiority trial. Enrolment required a SB >= 2.75 mm, >= 50% diameter stenosis in both vessels, and allowed SB lesion length up to 15 mm. The primary endpoint was a composite of cardiac death, non-procedural myocardial infarction and target lesion revascularisation at 6 months. Two-year clinical follow-up was included in this primary reporting due to lower than expected event rates.Results: A total of 450 patients were assigned to simple stenting (n = 221) or complex stenting (n=229) in 14 Nordic and Baltic centres. Two-year follow-up was available in 218 (98.6%) and 228 (99.5%) patients, respectively. The primary endpoint of major adverse cardiac events (MACE) at 6 months was 5.5% vs 2.2% (risk differences 3.2%, 95% CI -0.2 to 6.8, p=0.07) and at 2 years 12.9% vs 8.4% (HR 0.63, 95% CI 0.35 to 1.13, p = 0.12) after simple versus complex treatment. In the subgroup treated by newer generation drug-eluting stents, MACE was 12.0% vs 5.6% (HR 0.45, 95% CI 0.17 to 1.17, p = 0.10) after simple versus complex treatment.Conclusion: In the treatment of bifurcation lesions involving a large SB with ostial stenosis, routine two-stent techniques did not improve outcome significantly compared with treatment by the simpler main vessel stenting technique after 2 years.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Open heart
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- By the author/editor
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Kumsars, Indulis
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Holm, Niels Rams ...
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Niemelä, Matti
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Erglis, Andrejs
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Kervinen, Kari
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Christiansen, Ev ...
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Maeng, Michael
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Dombrovskis, And ...
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Abraitis, Vytaut ...
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Kibarskis, Aleks ...
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Trovik, Thor
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Latkovskis, Gust ...
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Sondore, Dace
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Narbute, Inga
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Terkelsen, Chris ...
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Eskola, Markku
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Romppanen, Hannu
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Laine, Mika
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Jensen, Lisette ...
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Pietila, Mikko
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Gunnes, Pal
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Hebsgaard, Lasse
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Fröbert, Ole, 19 ...
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Calais, Fredrik, ...
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Hartikainen, Juh ...
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Aarøe, Jens
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Ravkilde, Jan
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Engstrøm, Thomas
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Steigen, Terje K ...
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Thuesen, Leif
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Lassen, Jens F.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Open heart
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Örebro University