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Global variability of the human IgG glycome

Štambuk, Jerko (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Nakić, Natali (författare)
Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy
Vučković, Frano (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
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Pučić-Baković, Maja (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Razdorov, Genadij (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Trbojević-Akmačić, Irena (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Novokmet, Mislav (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Keser, Toma (författare)
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Vilaj, Marija (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Štambuk, Tamara (författare)
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Gudelj, Ivan (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia
Šimurina, Mirna (författare)
Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Song, Manshu (författare)
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Wang, Hao (författare)
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Salihović, Marijana Peričić (författare)
Institute for Anthropological Research, Zagreb, Croatia
Campbell, Harry (författare)
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
Rudan, Igor (författare)
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
Kolčić, Ivana (författare)
School of Medicine, University of Split, Split, Croatia
Eller, Leigh Anne (författare)
Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
McKeigue, Paul (författare)
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom
Robb, Merlin L. (författare)
Walter Reed Army Institute of Research, Silver Spring, MD, USA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology
Kurtoglu, Metin (författare)
Department of Oncology, Koç University School of Medicine, Istanbul, Turkey
Annese, Vito (författare)
Careggi University Hospital, Florence, Italy
Škarić-Jurić, Tatjana (författare)
Institute for Anthropological Research, Zagreb, Croatia
Molokhia, Mariam (författare)
School of Population Health and Environmental Sciences, King's College London, London, United Kingdom
Polašek, Ozren (författare)
School of Medicine, University of Split, Split, Croatia
Hayward, Caroline (författare)
MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Kibuuka, Hannah (författare)
Makerere University Walter Reed Project, Kampala, Uganda
Thaqi, Kujtim (författare)
Institute of Clinical Biochemistry, Priština, Kosovo
Primorac, Dragan (författare)
St. Catherine Hospital, Zagreb, Croatia
Gieger, Christian (författare)
Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
Nitayaphan, Sorachai (författare)
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Spector, Tim (författare)
Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
Wang, Youxin (författare)
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Tillin, Therese (författare)
Institute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom
Chaturvedi, Nish (författare)
Institute of Cardiovascular Science, Faculty of Population Health Sciences, London, United Kingdom
Wilson, James F. (författare)
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom; MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Schanfield, Moses (författare)
Department of Forensic Sciences, George Washington University, Washington, USA
Filipenko, Maxim (författare)
Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia
Wang, Wei (författare)
Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China; School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
Lauc, Gordan (författare)
Genos Glycoscience Research Laboratory, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
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 (creator_code:org_t)
2020-08-12
2020
Engelska.
Ingår i: Aging. - : Impact Journals LLC. - 1945-4589 .- 1945-4589. ; 12:15, s. 15222-15259
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG's fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

Fc glycosylation
aging
glycans
immunoglobulin G
mass spectrometry

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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