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Sökning: WFRF:(Hedman Linnea 1979 ) > Bunne Joakim

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1.
  • Bunne, Joakim, 1987- (författare)
  • Allergic sensitization among schoolchildren in northern Sweden : time trends, risk factors and relation to asthma, allergic rhinitis and lung function.
  • 2024
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Background: Asthma and allergic rhinitis are common chronic diseases of childhood.Their prevalence has increased globally in the 20th century, with regionally diverging trends in recent years. Allergic sensitization (AS) is strongly associated with asthma and allergic rhinitis (AR), with similar trends over time and uncertainty of development in recent years. AS increases in childhood until young adulthood. Risk factors for AS are not as well characterized as for asthma and AR, and important aspects of the relation between AS and disease are not known. This includes why some sensitized children do not develop disease and how common this is in a longitudinal perspective. While many studies have assessed AS in the first years of life, fewer have focused on school age, and none have focused on the effect of age at onset of AS. Further, the association between AS and lung function is unknown.Aims: To assess time trends in prevalence, incidence and factors associated with AS in schoolchildren. Further, to assess the association between AS and asthma, allergic rhinitis and lung function, with special interest in age at onset of sensitization.Methods: Children in grades 1 and 2 (median age 8 years) in two municipalities in northern Sweden were invited to a questionnaire study of allergic diseases and skin prick tests to common aeroallergens in 1996. The cohort was reassessed at 12 and at 19 years also including spirometry. Identical methods were used to recruit a second and third cohort in 2006 and 2017.Results: The prevalence of AS at 8 years was 21% (1996), 30% (2006) and 30% (2017). Patterns of sensitization and risk factors for sensitization were similar. In the second cohort, the incidence between 8-12 years of 18% and prevalence of 41% at 12 years were higher than in the first cohort. Compared with later onset, sensitization ≤8 years was more strongly associated with asthma and allergic rhinitis at 19 years. AS was not independently associated with lung function at 19 years.Conclusions: In northern Sweden, the increase in allergic sensitization at age 8 years between 1996 and 2006 has halted in recent years. The increase between the first two cohorts was seen also at age 12 years. Age at onset of allergic sensitization impacts development of asthma and allergic rhinitis until 19 years. Despite an association with asthma, sensitization does not affect lung function at 19 years. 
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2.
  • Bunne, Joakim, et al. (författare)
  • The Majority of Children Sensitized Before School-Age Develop Allergic Disease Before Adulthood: A Longitudinal Population-Based Study
  • 2022
  • Ingår i: Journal of Allergy and Clinical Immunology: In Practice. - : Elsevier BV. - 2213-2198 .- 2213-2201. ; 10:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: Allergic sensitization increases the risk of asthma and allergic rhinitis, but the impact of age at onset of sensitization is less studied. Objective: To examine the cumulative incidence of asthma and rhinitis up to age 19 years in relation to age at onset of sensitization to airborne allergens. Method: All children in grade 1 and 2 (median age, 8 years) in 2 municipalities in Northern Sweden were invited to undergo skin prick tests and answer a questionnaire about allergic diseases, and 88% participated. At ages 12 and 19 years, the protocol was repeated, and 1510 individuals participated in all 3 examinations. Specific IgE data were collected in a random sample at age 19 years (n = 770). Onset of sensitization was defined: 8 years or less, 8 to 12 years, 12 to 19 years, and never sensitized. Adjusted Poisson regression was used to calculate risk ratios (RRs). Results: At 19 years, those sensitized at 8 years of age or earlier had the highest risk of asthma (RR, 4.68; 95% CI, 3.15-6.97) and rhinitis (RR, 22.3; 95% CI, 13.3-37.6), and 84% had developed either asthma or rhinitis. The combination of sensitization at age 8 years or earlier and family history of allergic diseases rendered high risks for asthma (RR, 10.6; 95% CI, 6.71-16.7) and rhinitis (RR, 36.3; 95% CI, 18.9-69.7). Individuals sensitized at age 8 years or earlier showed significantly highest level of sensitization, as judged by number of positive skin test results and titers of specific IgE. Conclusions: Most individuals with sensitization at age 8 years or earlier developed asthma or rhinitis before young adulthood. The high level of sensitization in those sensitized early contributes to the high incidence of allergic airway conditions. © 2021 The Authors
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3.
  • Rönmark, Eva, et al. (författare)
  • Prevalence and risk factors for allergic sensitization : 3 cross-sectional studies among schoolchildren from 1996 to 2017
  • 2023
  • Ingår i: Journal of Allergy and Clinical Immunology: Global. - : Elsevier. - 2772-8293. ; 2:4
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: The prevalence of allergic sensitization and allergic diseases has increased for decades in Northern Europe, but recent studies are lacking.Objective: We sought to study the prevalence trends of allergic sensitization, associated risk factors, and the association with asthma and allergic rhinitis (AR) among children in Northern Sweden.Methods: Three cohorts of children aged 7 to 8 years participated in a skin prick test (SPT) with 10 airborne allergens in 1996, 2006, and 2017, with 2148, 1693, and 1762 participants tested, respectively, representing 87% to 90% of schoolchildren in the catchment communities. Adjusted Poisson regression was used to identify risk factors for allergic sensitization and the association with asthma and AR.Results: The prevalence of any positive SPT response increased from 21% in 1996 to 30% in 2006 and remained at 30% in 2017 (P <.001). Sensitization to cat was the most common for all the years. The risk factor pattern for a positive SPT response was similar in all examinations, with positive and significant associations with a family history of allergy (risk ratio, 1.4-1.5) and negative and significant associations with having a cat at home (risk ratio, 0.7-0.8). The prevalence of physician-diagnosed asthma increased, but the association with allergic sensitization weakened. The opposite trends were found for AR—decreasing prevalence and strengthened association with allergic sensitization.Conclusions: The prevalence of allergic sensitization increased from 1996 to 2006 but plateaued in the next decade, whereas the risk factor pattern remained stable. The diverging trends of associations between allergic sensitization and asthma and AR suggest secular trends in the clinical management of allergic diseases.
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