Search: WFRF:(Heilmann Heimbach S)
> (2021)
> Kivipelto M >
Common variants in ...
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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de Rojas, I. (author)
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Moreno-Grau, S. (author)
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- Tesi, N. (author)
- Karolinska Institutet
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Grenier-Boley, B. (author)
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Andrade, V. (author)
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Jansen, I. E. (author)
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- Pedersen, N. L. (author)
- Karolinska Institutet
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Stringa, N. (author)
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- Zettergren, Anna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Hernández, I. (author)
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Montrreal, L. (author)
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Antúnez, C. (author)
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- Antonell, A. (author)
- Karolinska Institutet
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Tankard, R. M. (author)
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Bis, J. C. (author)
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Sims, R. (author)
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Bellenguez, C. (author)
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Quintela, I. (author)
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González-Perez, A. (author)
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Calero, M. (author)
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Franco-Macías, E. (author)
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Macías, J. (author)
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Blesa, R. (author)
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Cervera-Carles, L. (author)
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Menéndez-González, M. (author)
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Frank-García, A. (author)
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Royo, J. L. (author)
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Moreno, F. (author)
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Huerto Vilas, R. (author)
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Baquero, M. (author)
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- Diez-Fairen, M. (author)
- Karolinska Institutet
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Lage, C. (author)
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García-Madrona, S. (author)
-
- García-González, P. (author)
- Karolinska Institutet
-
Alarcón-Martín, E. (author)
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Valero, S. (author)
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Sotolongo-Grau, O. (author)
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Ullgren, A. (author)
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Naj, A. C. (author)
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Lemstra, A. W. (author)
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Benaque, A. (author)
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Pérez-Cordón, A. (author)
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Benussi, A. (author)
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Rábano, A. (author)
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Padovani, A. (author)
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Squassina, A. (author)
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- de Mendonça, A. (author)
- Karolinska Institutet
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Arias Pastor, A. (author)
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Kok, A. A. L. (author)
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Meggy, A. (author)
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Pastor, A. B. (author)
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Espinosa, A. (author)
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Corma-Gómez, A. (author)
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Martín Montes, A. (author)
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Sanabria, Á (author)
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DeStefano, A. L. (author)
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Schneider, A. (author)
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Haapasalo, A. (author)
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Kinhult Ståhlbom, A. (author)
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Tybjærg-Hansen, A. (author)
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Hartmann, A. M. (author)
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Spottke, A. (author)
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Corbatón-Anchuelo, A. (author)
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Rongve, A. (author)
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Borroni, B. (author)
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Arosio, B. (author)
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Nacmias, B. (author)
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- Nordestgaard, B. G. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Kunkle, B. W. (author)
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- Charbonnier, C. (author)
- Karolinska Institutet
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Abdelnour, C. (author)
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Masullo, C. (author)
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Martínez Rodríguez, C. (author)
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Muñoz-Fernandez, C. (author)
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Dufouil, C. (author)
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Graff, C. (author)
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Chillotti, C. (author)
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Fenoglio, C. (author)
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Clark, C. (author)
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Pisanu, C. (author)
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Holmes, C. (author)
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Buiza-Rueda, D. (author)
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Aarsland, D. (author)
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Conti, E. (author)
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Rubino, E. (author)
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Gelpi, E. (author)
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Rodriguez-Rodriguez, E. (author)
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Duron, E. (author)
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Boerwinkle, E. (author)
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Ferri, E. (author)
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Tagliavini, F. (author)
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Küçükali, F. (author)
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Pasquier, F. (author)
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Mangialasche, F. (author)
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Jessen, F. (author)
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Selbæk, G. (author)
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Ortega, G. (author)
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Rossi, G. (author)
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Spalletta, G. (author)
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Giaccone, G. (author)
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Grande, G. (author)
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Binetti, G. (author)
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- Papenberg, G. (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Hampel, H. (author)
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Bailly, H. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Soininen, H. (author)
- Karolinska Institutet
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- Karlsson, Ida K. (author)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Alvarez, I. (author)
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Appollonio, I. (author)
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Giegling, I. (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Saltvedt, I. (author)
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Diehl-Schmid, J. (author)
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Popp, J. (author)
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Deckert, J. (author)
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Buerger, K. (author)
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- Morgan, K. (author)
- Karolinska Institutet
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Fließbach, K. (author)
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Sleegers, K. (author)
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Molina-Porcel, L. (author)
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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Weinhold, L. (author)
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Farrer, L. A. (author)
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Wang, L. S. (author)
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Kleineidam, L. (author)
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Farotti, L. (author)
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Hulsman, M. (author)
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Spallazzi, M. (author)
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Esiri, M. (author)
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Bernal Sánchez-Arjona, M. (author)
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Dalmasso, M. C. (author)
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Arcaro, M. (author)
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Nöthen, M. M. (author)
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Fernández-Fuertes, M. (author)
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Dichgans, M. (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Herrmann, M. J. (author)
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Scherer, M. (author)
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Vyhnalek, M. (author)
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Kosmidis, M. H. (author)
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Heneka, M. T. (author)
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Wagner, M. (author)
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Scamosci, M. (author)
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Kivipelto, M. (author)
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Hiltunen, M. (author)
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Zulaica, M. (author)
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Alegret, M. (author)
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Fornage, M. (author)
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Roberto, N. (author)
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van Schoor, N. M. (author)
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- Seidu, Nazib (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Banaj, N. (author)
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Scarmeas, N. (author)
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Scherbaum, N. (author)
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Goldhardt, O. (author)
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Engelborghs, S. (author)
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Botne Sando, S. (author)
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- Kern, Silke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Archetti, S. (author)
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Boschi, S. (author)
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Gil, S. (author)
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Ciccone, S. (author)
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Djurovic, S. (author)
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Escott-Price, V. (author)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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Deramecourt, V. (author)
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Maier, W. (author)
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Jian, X. (author)
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Pijnenburg, Y. A. L. (author)
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Vicente, M. P. (author)
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Vigo-Ortega, R. (author)
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Vivancos, L. (author)
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Macleod, C. (author)
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McCracken, C. (author)
-
Brayne, C. (author)
-
Bresner, C. (author)
-
Grozeva, D. (author)
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Bellou, E. (author)
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Sommerville, E. W. (author)
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Matthews, F. (author)
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Leonenko, G. (author)
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Menzies, G. (author)
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Windle, G. (author)
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Harwood, J. (author)
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Phillips, J. (author)
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Bennett, K. (author)
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Luckuck, L. (author)
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Clare, L. (author)
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Woods, R. (author)
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Saad, S. (author)
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Burholt, V. (author)
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Jansen, I. E. (author)
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Rongve, A. (author)
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Kehoe, P. G. (author)
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Garcia-Ribas, G. (author)
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Sánchez-Juan, P. (author)
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Pastor, P. (author)
-
Pérez-Tur, J. (author)
-
Piñol-Ripoll, G. (author)
-
Lopez de Munain, A. (author)
-
García-Alberca, J. M. (author)
-
Bullido, M. J. (author)
-
Álvarez, V. (author)
-
Lleó, A. (author)
-
Real, L. M. (author)
-
Mir, P. (author)
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Medina, M. (author)
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Scheltens, P. (author)
-
Holstege, H. (author)
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Marquié, M. (author)
-
Sáez, M. E. (author)
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Carracedo, Á (author)
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Amouyel, P. (author)
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Schellenberg, G. D. (author)
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Williams, J. (author)
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Seshadri, S. (author)
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van Duijn, C. M. (author)
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Mather, K. A. (author)
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Sánchez-Valle, R. (author)
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Serrano-Ríos, M. (author)
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Orellana, A. (author)
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Tárraga, L. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Huisman, M. (author)
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Andreassen, O. A. (author)
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Posthuma, D. (author)
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Clarimón, J. (author)
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Boada, M. (author)
-
van der Flier, W. M. (author)
-
Ramirez, A. (author)
-
Lambert, J. C. (author)
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van der Lee, S. J. (author)
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Ruiz, A. (author)
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(creator_code:org_t)
- 2021-06-07
- 2021
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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https://doi.org/10.1...
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https://www.nature.c...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- detection method
- genetic analysis
- nervous system disorder
- public health
- risk assessment
- risk factor
- stratification
- amyloid precursor protein
- apolipoprotein E
- APP protein
- human
- aged
- Alzheimer disease
- case control study
- cohort analysis
- female
- follow up
- genetic predisposition
- genetics
- genome-wide association study
- heterozygote
- human
- information processing
- male
- metabolism
- middle aged
- multifactorial inheritance
- onset age
- pathology
- procedures
- single nucleotide polymorphism
- very elderly
- Age of Onset
- Aged
- 80 and over
- Amyloid beta-Protein Precursor
- Apolipoproteins E
- Case-Control Studies
- Cohort Studies
- Datasets as Topic
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Polymorphism
- Single Nucleotide
- Risk Factors
- detection method
Publication and Content Type
- ref (subject category)
- art (subject category)
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de Rojas, I.
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Moreno-Grau, S.
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Sánchez-Juan, P.
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Sastre, I.
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Vicente, M. P.
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Vigo-Ortega, R.
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Vivancos, L.
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Macleod, C.
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McCracken, C.
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Brayne, C.
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Bresner, C.
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Grozeva, D.
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Bellou, E.
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Sommerville, E. ...
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Matthews, F.
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Leonenko, G.
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Menzies, G.
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Windle, G.
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Harwood, J.
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Phillips, J.
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Bennett, K.
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Luckuck, L.
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Clare, L.
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Woods, R.
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Saad, S.
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Burholt, V.
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Kehoe, P. G.
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Scheltens, P.
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Holstege, H.
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Carracedo, Á
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Amouyel, P.
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Schellenberg, G. ...
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Williams, J.
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Seshadri, S.
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van Duijn, C. M.
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Mather, K. A.
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Sánchez-Valle, R ...
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Serrano-Ríos, M.
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Blennow, Kaj, 19 ...
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Huisman, M.
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Andreassen, O. A ...
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Posthuma, D.
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van der Flier, W ...
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Ramirez, A.
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Lambert, J. C.
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van der Lee, S. ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Geriatrics
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- By the university
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University of Gothenburg
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Stockholm University
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Jönköping University
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Uppsala University
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Karolinska Institutet