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RAD51 can inhibit P...
RAD51 can inhibit PDGFB-induced gliomagenesis and genomic instability
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- Westermark, Ulrica K (author)
- Karolinska Institutet
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- Lindberg, Nanna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Roswall, Pernilla (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Bråsäter, Daniel (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Helgadottir, Hildur R (author)
- Memorial Sloan-Kettering Cancer Center, New York
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- Hede, Sanna (author)
- Karolinska Institutet, Institutionen för onkologi-patologi,Monica Nistér
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- Zetterberg, Anders (author)
- Karolinska Institutet
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- Jasin, Maria (author)
- Memorial Sloan-Kettering Cancer Center, New York
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- Nistér, Monica (author)
- Karolinska Institutet
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- Uhrbom, Lene (author)
- Uppsala universitet,Cancer och vaskulärbiologi
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(creator_code:org_t)
- 2011-09-16
- 2011
- English.
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In: Neuro-Oncology. - : Oxford University Press (OUP). - 1522-8517 .- 1523-5866. ; 13:12, s. 1277-1287
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Faithful replication and DNA repair are vital for maintenance of genome integrity. RAD51 is a central protein in homologous recombination repair and during replication, when it protects and restarts stalled replication forks. Aberrant RAD51 expression occurs in glioma, and high expression has been shown to correlate with prolonged survival. Furthermore, genes involved in DNA damage response (DDR) are mutated or deleted in human glioblastomas, corroborating the importance of proper DNA repair to suppress gliomagenesis. We have analyzed DDR and genomic instability in PDGF-B-induced gliomas and investigated the role of RAD51 in glioma development. We show that PDGF-B-induced gliomas display genomic instability and that co-expression of RAD51 can suppress PDGF-B-induced tumorigenesis and prolong survival. Expression of RAD51 inhibited proliferation and genomic instability of tumor cells independent of Arf status. Our results demonstrate that the RAD51 pathway can prevent glioma initiation and maintain genome integrity of induced tumors, suggesting reactivation of the RAD51 pathway as a potential therapeutic avenue.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- genomic instability
- glioma
- PDGF-B
- RAD51
- replicative stress
- Morphology, cell biology, pathology
- Morfologi, cellbiologi, patologi
- Medical Cell Biology
- Medicinsk cellbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Westermark, Ulri ...
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Lindberg, Nanna
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Roswall, Pernill ...
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Bråsäter, Daniel
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Helgadottir, Hil ...
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Hede, Sanna
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Zetterberg, Ande ...
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Jasin, Maria
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Nistér, Monica
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Uhrbom, Lene
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Neuro-Oncology
- By the university
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Uppsala University
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Karolinska Institutet