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| 2. |
- Bott, Lukas Thomas, et al.
(författare)
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Coulomb dissociation of O-16 into He-4 and C-12
- 2023
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Ingår i: NUCLEAR PHYSICS IN ASTROPHYSICS - X, NPA-X 2022. - : EDP Sciences. - 2100-014X. ; 279
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Konferensbidrag (refereegranskat)abstract
- We measured the Coulomb dissociation of O-16 into He-4 and C-12 within the FAIR Phase-0 program at GSI Helmholtzzentrum fur Schwerionenforschung Darmstadt, Germany. From this we will extract the photon dissociation cross section O-16(alpha,gamma)C-12, which is the time reversed reaction to C-12(alpha,gamma)O-16. With this indirect method, we aim to improve on the accuracy of the experimental data at lower energies than measured so far. The expected low cross section for the Coulomb dissociation reaction and close magnetic rigidity of beam and fragments demand a high precision measurement. Hence, new detector systems were built and radical changes to the (RB)-B-3 setup were necessary to cope with the high-intensity O-16 beam. All tracking detectors were designed to let the unreacted O-16 ions pass, while detecting the C-12 and He-4.
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| 3. |
- Führes, Tobit, et al.
(författare)
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Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver
- 2022
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Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 87:2, s. 859-871
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: Intravoxel incoherent motion (IVIM) studies are performed with different acquisition protocols. Comparing them requires knowledge of echo time (TE) dependencies. The TE-dependence of the biexponential perfusion fraction f is well-documented, unlike that of its triexponential counterparts f1 and f2 and the biexponential and triexponential pseudodiffusion coefficients D*, (Formula presented.), and (Formula presented.). The purpose was to investigate the TE-dependence of these parameters and to check whether the triexponential pseudodiffusion compartments are associated with arterial and venous blood. Methods: Fifteen healthy volunteers (19-58 y; mean: 24.7 y) underwent diffusion-weighted imaging of the abdomen with 24 b-values (0.2-800 s/mm2) at TEs of 45, 60, 75, and 90 ms. Regions of interest (ROIs) were manually drawn in the liver. One set of bi- and triexponential IVIM parameters per volunteer and TE was determined. The TE-dependence was assessed with the Kruskal-Wallis test. Results: TE-dependence was observed for f (P <.001), f1 (P =.001), and f2 (P <.001). Their median values at the four measured TEs were: f: 0.198/0.240/0.274/0.359, f1: 0.113/0.139/0.146/0.205, f2: 0.115/0.155/0.182/0.194. D, D*, (Formula presented.), and (Formula presented.) showed no significant TE-dependence. Their values were: diffusion coefficient D (10−4 mm2/s): 9.45/9.63/9.75/9.41, biexponential D* (10−2 mm2/s): 5.26/5.52/6.13/5.82, triexponential (Formula presented.) (10−2 mm2/s): 1.73/2.91/2.25/2.51, triexponential (Formula presented.) (mm2/s): 0.478/1.385/0.616/0.846. Conclusion: f1 and f2 show similar TE-dependence as f, ie, increase with rising TE; an effect that must be accounted for when comparing different studies. The diffusion and pseudodiffusion coefficients might be compared without TE correction. Because of the similar TE-dependence of f1 and f2, the triexponential pseudodiffusion compartments are most probably not associated to venous and arterial blood.
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| 4. |
- Hensel, Michael U., 1965, et al.
(författare)
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Current changes in conditions and contexts for architectural research and practice: A brief introduction
- 2019
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Ingår i: The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice. - New York : Routledge, 2019. : Routledge. ; , s. 1-13
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The discipline of architecture is currently undergoing a significant change as professional practice and academia seem to be transforming one another specifically through succinct research undertakings. This book continues the discussion started in The Changing Shape of Practice – Integrating Research and Design in Architecture on architectural offices’ modes of research and lines of inquiry in architecture and how it reshapes practice. The book aims to contribute to the mapping and discussion on research in architectural practice and its transformational impact and gives input to the discussions on where the architectural profession is heading. In this second volume, various research initiatives and modes in architectural practices are portrayed. The book also includes contributions that broaden the scope and put the developments into larger contexts, and present an overview of developments from different regional perspectives and of various social aspects of architecture. It also relates the developments in practice to educational efforts and to initiatives where the more traditional role of architects is challenged. The contributions include chapters by Walter Unterrainer, Anthony Burke, Renée Cheng and Andrea J. Johnson, and Michael U. Hensel, and on the practices atelier d’architecture autogérée, Helen & Hard, MVRDV and The Why Factory, NADAAA & Nader Tehrani, Nordic – Office of Architecture, Schmidt Hammer Lassen, Skidmore, Owings & Merrill, Void, Sarah Wigglesworth Architects, and Älvstranden Utveckling.
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| 5. |
- Hensel, Michael U., 1965, et al.
(författare)
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The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice
- 2019
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Ingår i: The Changing Shape of Architecture: Further Cases of Integrating Research and Design in Practice. - London : Routledge. - 9781315284088
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- The discipline of architecture if currently undergoing a significant change as professional practice and academia seem to be transforming one another specifically through succinct research undertakings. This book continues the discussion started in The Changing Shape of Practice – Integrating Research and Design in Architecture on architectural offices’ modes of research and lines of inquiry in architecture and how it reshapes practice. The book aims to contribute to the mapping and discussion on research in architectural practice and its transformational impact and gives input to the discussions on where the architectural profession is heading. In this second volume various research initiatives and modes in architectural practices are portrayed. The book also includes contributions that broadens the scope and puts the developments into larger contexts and presents an overview of developments from different regional perspectives and of various social aspects of architecture. It also relates the developments in practice to educational efforts and to initiatives where the more traditional role of architects is challenged. The contributions include chapters by Walter Unterrainer, Anthony Burke, Renée Cheng and Andrea J. Johnson, and Michael Hensel and on the practices atelier d’architecture autogérée, Helen & Hard, MVRDV and The Why Factory, NADAAA & Nader Tehrani, Nordic – Office of Architecture, Schmidt Hammer Lassen, Skidmore, Owings & Merrill, Void, Sarah Wigglesworth Architects, and Älvstranden Utveckling.
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| 6. |
- Hensel, Michael U., 1965, et al.
(författare)
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The Changing Shape of Practice. Integrating Research and Design in Architecture
- 2016
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Architectural practices worldwide have to deal with increasingly complex design requirements. How do practices acquire the ability to do so? The Changing Shape of Practice provides a handbook of examples for practices that wish to integrate more research into their work and a reference book for students that seek to prepare themselves for the changing shape of practice in architecture. It addresses the increasing integration of research undertaken in architectural practices of different sizes ranging from small to very large practices from the UK, USA, Europe and Asia. The book is organized according to the size of the practices which is significant in that it addresses the different structures and resourcing requirements that are enabled by specific practice sizes, as this determines and constrains the type, scope and modes of research available to a given practice. The practices covered include: Woods Bagot, Perkins + Will, White, AECOM, UN Studio, Shop Architects, PLP Architecture, Kieran Timberlake, 3XN / GXN, ONL, AZPML, Thomas Herzog + Partners, Herreros Arquitectos, Spacescape, OCEAN Design Research Association By taking stock of the current shape of practice, the book provides essential information for professional architects who are integrating research into their practice.
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| 7. |
- Messing, Jutta, et al.
(författare)
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Antiadhesive Properties of Abelmoschus esculentus (Okra) Immature Fruit Extract against Helicobacter pylori Adhesion
- 2014
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 9:1, s. e84836-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Traditional Asian and African medicine use immature okra fruits (Abelmoschus esculentus) as mucilaginous food to combat gastritis. Its effectiveness is due to polysaccharides that inhibit the adhesion of Helicobacter pylori to stomach tissue. The present study investigates the antiadhesive effect in mechanistic detail. Methodology: A standardized aqueous fresh extract (Okra FE) from immature okra fruits was used for a quantitative in vitro adhesion assay with FITC-labled H. pylori J99, 2 clinical isolates, AGS cells, and fluorescence-activated cell sorting. Bacterial adhesins affected by FE were pinpointed using a dot-blot overlay assay with immobilized Lewis(b), sialyl-Lewis(a), H-1, laminin, and fibronectin. I-125-radiolabeled Okra FE polymer served for binding studies to different H. pylori strains and interaction experiments with BabA and SabA. Iron nanoparticles with different coatings were used to investigate the influence of the charge-dependence of an interaction on the H. pylori surface. Principal findings: Okra FE dose-dependently (0.2 to 2 mg/mL) inhibited H. pylori binding to AGS cells. FE inhibited the adhesive binding of membrane proteins BabA, SabA, and HpA to its specific ligands. Radiolabeled compounds from FE bound non-specifically to different strains of H. pylori, as well as to BabA/SabA deficient mutants, indicating an interaction with a still-unknown membrane structure in the vicinity of the adhesins. The binding depended on the charge of the inhibitors. Okra FE did not lead to subsequent feedback regulation or increased expression of adhesins or virulence factors. Conclusion: Non-specific interactions between high molecular compounds from okra fruits and the H. pylori surface lead to strong antiadhesive effects.
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| 8. |
- Messing, Jutta, et al.
(författare)
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Antiadhesive Properties of Arabinogalactan Protein from Ribes nigrum Seeds against Bacterial Adhesion of Helicobacter pylori
- 2014
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Ingår i: Molecules. - : MDPI AG. - 1431-5157 .- 1420-3049. ; 19:3, s. 3696-3717
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Tidskriftsartikel (refereegranskat)abstract
- Fruit extracts from black currants (Ribes nigrum L.) are traditionally used for treatment of gastritis based on seed polysaccharides that inhibit the adhesion of Helicobacter pylori to stomach cells. For detailed investigations an arabinogalactan protein (F2) was isolated from seeds and characterized concerning molecular weight, carbohydrate, amino acid composition, linkage, configuration and reaction with beta-glucosyl Yariv. Functional testing of F2 was performed by semiquantitative in situ adhesion assay on sections of human gastric mucosa and by quantitative in vitro adhesion assay with FITC-labled H. pylori strain J99 and human stomach AGS cells. Bacterial adhesins affected were identified by overlay assay with immobilized ligands. I-125-radiolabeled F2 served for binding studies to H. pylori and interaction experiments with BabA and SabA. F2 had no cytotoxic effects against H. pylori and AGS cells; but inhibited bacterial binding to human gastric cells. F2 inhibited the binding of BabA and fibronectin-binding adhesin to its specific ligands. Radiolabeled F2 bound non-specifically to different strains of H. pylori; and to BabA deficient mutant. F2 did not lead to subsequent feedback regulation or increased expression of adhesins or virulence factors. From these data the non-specific interactions between F2 and the H. pylori lead to moderate antiadhesive effects.
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| 9. |
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