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- Frick, Inga-Maria, et al.
(författare)
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Infectious Agents, the Contact System, and Innate Immunity
- 2008
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Ingår i: Progress and Challenges in Transfusion Medicine, Hemostasis, and Hemotherapy State of the Art 2008. - 9783805586597 ; , s. 60-70
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Konferensbidrag (refereegranskat)abstract
- The early host response to an infection is dependent on an efficient innate immune system. The human contact system once activated at a bacterial surface results in the induction of proinflammatory reactions and the release of antimicrobial peptides, However, under severe conditions its systemic activation A may evoke the generation of pathologic levels of kinins and a consumption of contact factors, which can both contribute to the progression of the disease and cause life-threatening complications. The present review aims to give an update on the role of the contact system in infectious diseases. (C) 2008 S. Karger GmbH, Freiburg i.Br.
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