International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

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International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Condoluci, Adalgisa (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

di Bergamo, Lodovico Terzi (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.

Langerbeins, Petra (författare): Univ Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany.

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Hoechstetter, Manuela A. (författare): German CLL Study Grp, Hosp Munich Schwabing, Munich, Germany.

Herling, Carmen D. (författare): Univ Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany.

De Paoli, Lorenzo (författare): Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy.

Delgado, Julio (författare): Hosp Clin Barcelona, Barcelona, Spain.

Rabe, Kari G. (författare): Mayo Clin, Rochester, MN USA.

Gentile, Massimo (författare): Azienda Osped Cosenza, Cosenza, Italy.

Doubek, Michael (författare): Masaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.

Mauro, Francesca R. (författare): Karolinska Institutet

Chiodin, Giorgia (författare): Univ Southampton, Canc Sci Div, Southampton, Hants, England.

Mattsson, Mattias (författare): Uppsala universitet,Experimentell och klinisk onkologi

Bahlo, Jasmin (författare): Univ Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany.

Cutrona, Giovanna (författare): IRCCS Osped Policlin San Martino, Genoa, Italy.

Kotaskova, Jana (författare): Masaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.

Deambrogi, Clara (författare): Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy.

Smedby, Karin E. (författare): Karolinska Institutet

Spina, Valeria (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.

Bruscaggin, Alessio (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.

Wu, Wei (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;IRCCS Osped Policlin San Martino, Genoa, Italy.

Moia, Riccardo (författare): Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy.

Bianchi, Elena (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Gerber, Bernhard (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Zucca, Emanuele (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Gillessen, Silke (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Ghielmini, Michele (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Cavalli, Franco (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Stussi, Georg (författare): Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

Hess, Mark A. (författare): Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.

Baumann, Tycho S. (författare): Hosp Clin Barcelona, Barcelona, Spain.

Neri, Antonino (författare): Univ Milan, Dept Oncol & Hematooncol, Milan, Italy.

Ferrarini, Manlio (författare): Univ Genoa, Dept Expt Med, Genoa, Italy.

Rosenquist, Richard (författare): Karolinska Inst, Stockholm, Sweden. Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Nanjing, Peoples R China.

Forconi, Francesco (författare): Univ Southampton, Canc Sci Div, Southampton, Hants, England.;Southampton Univ Hosp Trust, Southampton, Hants, England.

Foa, Robin (författare): Sapienza Univ, Div Hematol, Rome, Italy.

Pospisilova, Sarka (författare): Masaryk Univ, Interni Hematol & Onkol Klin IHOK, Univ Hosp Brno, Brno, Czech Republic.;Masaryk Univ, Fac Med, Brno, Czech Republic.;Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.

Morabito, Fortunato (författare): Biotechnol Res Unit Aprigliano, Cosenza, Italy.;Augusta Victoria Hosp, Jerusalem, Israel.

Stilgenbauer, Stephan (författare): Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany.

Doehner, Hartmut (författare): Univ Hosp Ulm, Dept Internal Med 3, Ulm, Germany.

Parikh, Sameer A. (författare): Mayo Clin, Rochester, MN USA.

Wierda, William G. (författare): Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.

Montserrat, Emili (författare): Hosp Clin Barcelona, Barcelona, Spain.;Univ Barcelona, Inst Hematol & Oncol, Barcelona, Spain.

Gaidano, Gianluca (författare): Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy.

Hallek, Michael (författare): Univ Cologne, Cologne Bonn & German CLL Study Grp, Ctr Integrated Oncol, Cologne, Germany.

Rossi, Davide (författare): Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland.;Oncol Inst Southern Switzerland, Bellinzona, Switzerland.

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Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland;Oncol Inst Southern Switzerland, Bellinzona, Switzerland. Univ Svizzera Italiana, Oncol Res Inst, Bellinzona, Switzerland. (creator_code:org_t)

American Society of Hematology, 2020
2020
Engelska.
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 135:21, s. 1859-1869

Relaterad länk:: https://ashpublicati...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Most patients with chronic lymphocytic leukemia (CLL) are diagnosed with early-stage disease and managed with active surveillance. The individual course of patients with early-stage CLL is heterogeneous, and their probability of needing treatment is hardly anticipated at diagnosis. We aimed at developing an international prognostic score to predict time to first treatment (TTFT) in patients with CLL with early, asymptomatic disease (International Prognostic Score for Early-stage CLL [IPS-E]). Individual patient data from 11 international cohorts of patients with early-stage CLL (n = 4933) were analyzed to build and validate the prognostic score. Three covariates were consistently and independently correlated with TTFT: unmutated immunoglobulin heavy variable gene (IGHV), absolute lymphocyte count higher than 15 x 10(9)/L, and presence of palpable lymph nodes. The IPS-E was the sum of the covariates (1 point each), and separated low-risk (score 0), intermediate-risk (score 1), and high-risk (score 2-3) patients showing a distinct TTFT. The score accuracy was validated in 9 cohorts staged by the Binet system and 1 cohort staged by the Rai system. The C-index was 0.74 in the training series and 0.70 in the aggregate of validation series. By meta-analysis of the training and validation cohorts, the 5-year cumulative risk for treatment start was 8.4%, 28.4%, and 61.2% among low-risk, intermediate-risk, and high-risk patients, respectively. The IPS-E is a simple and robust prognostic model that predicts the likelihood of treatment requirement in patients with early-stage CLL. The IPS-E can be useful in clinical management and in the design of early intervention clinical trials.

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Av författaren/redakt...: Condoluci, Adalg ...; di Bergamo, Lodo ...; Langerbeins, Pet ...; Hoechstetter, Ma ...; Herling, Carmen ...; De Paoli, Lorenz ...; visa fler...; Delgado, Julio; Rabe, Kari G.; Gentile, Massimo; Doubek, Michael; Mauro, Francesca ...; Chiodin, Giorgia; Mattsson, Mattia ...; Bahlo, Jasmin; Cutrona, Giovann ...; Kotaskova, Jana; Deambrogi, Clara; Smedby, Karin E.; Spina, Valeria; Bruscaggin, Ales ...; Wu, Wei; Moia, Riccardo; Bianchi, Elena; Gerber, Bernhard; Zucca, Emanuele; Gillessen, Silke; Ghielmini, Miche ...; Cavalli, Franco; Stussi, Georg; Hess, Mark A.; Baumann, Tycho S ...; Neri, Antonino; Ferrarini, Manli ...; Rosenquist, Rich ...; Forconi, Frances ...; Foa, Robin; Pospisilova, Sar ...; Morabito, Fortun ...; Stilgenbauer, St ...; Doehner, Hartmut; Parikh, Sameer A ...; Wierda, William ...; Montserrat, Emil ...; Gaidano, Gianluc ...; Hallek, Michael; Rossi, Davide; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

Artiklar i publikationen: Blood

Av lärosätet: Uppsala universitet; Karolinska Institutet

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International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

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