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Search: WFRF:(Heyman I)

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  • Heyman, A., et al. (author)
  • Band structure and spin polarization for a one-dimensional array of quantum point contacts
  • 2004
  • In: Nanotechnology. - : IOP Publishing. - 0957-4484 .- 1361-6528. ; 15:1, s. 143-148
  • Journal article (peer-reviewed)abstract
    • We have numerically studied the band structure and the spin polarization effect in a periodic one-dimensional array of quantum point contacts (QPCs) formed in a two-dimensional electron gas in a plane-layered semiconductor system. In this study we used a self-consistent model developed within the framework of the Kohn-Sham local spin-density formalism. We have found that the band structure contains a mixture of flat and dispersed bands, and the role of transverse modes in the formation of such a band structure has been clearly demonstrated. We have also shown that spin polarization occurs mainly in the regions occupied by the QPCs and that it is qualitatively similar to the spin polarization in a single QPC.
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  • Bersellini Farinotti, Alex, et al. (author)
  • Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons
  • 2019
  • In: Journal of Experimental Medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 216:8, s. 1904-1924
  • Journal article (peer-reviewed)abstract
    • Rheumatoid arthritis-associated joint pain is frequently observed independent of disease activity, suggesting unidentified pain mechanisms. We demonstrate that antibodies binding to cartilage, specific for collagen type II (CII) or cartilage oligomeric matrix protein (COMP), elicit mechanical hypersensitivity in mice, uncoupled from visual, histological and molecular indications of inflammation. Cartilage antibody-induced pain-like behavior does not depend on complement activation or joint inflammation, but instead on tissue antigen recognition and local immune complex (IC) formation. smFISH and IHC suggest that neuronal Fcgr1 and Fcgr2b mRNA are transported to peripheral ends of primary afferents. CII-ICs directly activate cultured WT but not FcRγ chain-deficient DRG neurons. In line with this observation, CII-IC does not induce mechanical hypersensitivity in FcRγ chain-deficient mice. Furthermore, injection of CII antibodies does not generate pain-like behavior in FcRγ chain-deficient mice or mice lacking activating FcγRs in neurons. In summary, this study defines functional coupling between autoantibodies and pain transmission that may facilitate the development of new disease-relevant pain therapeutics.
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