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Sökning: WFRF:(Hilley A)

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1.
  • Bravo, L, et al. (författare)
  • 2021
  • swepub:Mat__t
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2.
  • Tabiri, S, et al. (författare)
  • 2021
  • swepub:Mat__t
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3.
  • Khatri, C, et al. (författare)
  • Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
  • 2021
  • Ingår i: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
  • Tidskriftsartikel (refereegranskat)abstract
    • Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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  • Goodfellow, Bradley W., et al. (författare)
  • Depth and character of rock weathering across a basaltic-hosted climosequence on Hawai` i
  • 2014
  • Ingår i: Earth Surface Processes and Landforms. - : Wiley. - 0197-9337 .- 1096-9837. ; 39:3, s. 381-398
  • Tidskriftsartikel (refereegranskat)abstract
    • Using field observations and geochemical and digital terrain analyses, we describe the structure and thickness of the regolith across a climosequence on the island of Hawaii to gain insight into the relative roles of precipitation and the near-surface hydrologic structure in determining weathering patterns. In the wet portion of the climosequence, where the long-term water balance is positive, the regolith thickness reaches an observed maximum of similar to 40m and appears limited by the geomorphic base-level of the landscape. However, even within this thick regolith, distinct units of varying weathering intensity occur; the vertical ordering of which largely reflects differences in the initial permeability structure of the basalt flows rather than a systematic decrease in weathering intensity downwards from the ground surface. In the dry portion of the climosequence, where the long-term water balance is negative, the regolith thickness is confined to similar to 1m, is highly dependent on the inferred permeability structure of the basalt flows, and is independent of geomorphic base-level. Weathering intensity also varies according to permeability structure and decreases in this thin regolith with distance beneath the ground surface. The abrupt change in regolith depth and character that coincides with the transition from net-positive to net-negative long-term water balance implies that small changes in precipitation rates around a neutral water balance result in large changes in the distribution and depth of weathering. Together our observations indicate that the distribution and depth of weathering in basalts (and probably other lithologies) might be best understood by considering how precipitation interacts with the complicated near-surface permeability structure over regolith-forming timescales to weather rock in the vadose zone.
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8.
  • Goodfellow, Bradley W., et al. (författare)
  • The chemical, mechanical, and hydrological evolution of weathering granitoid
  • 2016
  • Ingår i: Journal of Geophysical Research - Earth Surface. - 2169-9003 .- 2169-9011. ; 121:8, s. 1410-1435
  • Tidskriftsartikel (refereegranskat)abstract
    • Surprisingly few studies connect the chemical, mechanical, and hydrological evolution of rock as it weathers to saprolite and soil. We assess this coevolution in granodiorite from Monterey Peninsula, California, by measuring changes in bulk chemistry, mineralogy, volumetric strain, the oxidation state of Fe in biotite crystals, tensile strength, abrasion rate, connected porosity, and hydraulic conductivity in samples covering a range of weathering grades. We identify the oxidative dissolution of biotite as the key chemical reaction because of the volumetric expansion that accompanies formation of altered biotite and precipitation of ferrihydrite. We show how the associated accumulation of elastic strain produces an energy density that is sufficient to support rock fracturing over length scales equivalent to constituent crystals. The resulting intragranular and intergranular cracking profoundly reduces tensile strength and increases the abrasion rate, connected porosity, and hydraulic conductivity of the rock matrix. These changes increase the rate of plagioclase weathering, and ultimately the rock disintegrates into grus and clay. Major changes in rock properties can occur with only minor element leaching, and the threshold behavior of weathering that arises from the coevolution of chemical, hydrological, and mechanical properties may be difficult to capture using simplified weathering models that fail to incorporate these properties. Our results, which combine the mechanical and hydrological evolution of weathering rock with more common measurements of chemical changes, should help to more accurately model the effects of, and mechanical and hydrological feedbacks upon, chemical weathering of rock.
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9.
  • Peacock, Christopher S, et al. (författare)
  • Comparative genomic analysis of three Leishmania species that cause diverse human disease.
  • 2007
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 39:7, s. 839-847
  • Tidskriftsartikel (refereegranskat)abstract
    • Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader–associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage.
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10.
  • Schreurs, Guido, et al. (författare)
  • Benchmarking analogue models of brittle thrust wedges
  • 2016
  • Ingår i: Journal of Structural Geology. - : Elsevier BV. - 0191-8141 .- 1873-1201. ; 92, s. 116-139
  • Tidskriftsartikel (refereegranskat)abstract
    • We performed a quantitative comparison of brittle thrust wedge experiments to evaluate the variability among analogue models and to appraise the reproducibility and limits of model interpretation. Fifteen analogue modeling laboratories participated in this benchmark initiative. Each laboratory received a shipment of the same type of quartz and corundum sand and all laboratories adhered to a stringent model building protocol and used the same type of foil to cover base and sidewalls of the sandbox. Sieve structure, sifting height, filling rate, and details on off-scraping of excess sand followed prescribed procedures. Our analogue benchmark shows that even for simple plane-strain experiments with prescribed stringent model construction techniques, quantitative model results show variability, most notably for surface slope, thrust spacing and number of forward and backthrusts. One of the sources of the variability in model results is related to slight variations in how sand is deposited in the sandbox. Small changes in sifting height, sifting rate, and scraping will result in slightly heterogeneous material bulk densities, which will affect the mechanical properties of the sand, and will result in lateral and vertical differences in peak and boundary friction angles, as well as cohesion values once the model is constructed. Initial variations in basal friction are inferred to play the most important role in causing model variability. Our comparison shows that the human factor plays a decisive role, and even when one modeler repeats the same experiment, quantitative model results still show variability. Our observations highlight the limits of up-scaling quantitative analogue model results to nature or for making comparisons with numerical models. The frictional behavior of sand is highly sensitive to small variations in material state or experimental set-up, and hence, it will remain difficult to scale quantitative results such as number of thrusts, thrust spacing, and pop-up width from model to nature.
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