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Träfflista för sökning "WFRF:(Hokfelt T) srt2:(2005-2009);pers:(Kjaer S)"

Search: WFRF:(Hokfelt T) > (2005-2009) > Kjaer S

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  • Xia, S, et al. (author)
  • Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus
  • 2008
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 105:14, s. 5609-5613
  • Journal article (peer-reviewed)abstract
    • The neuropeptide galanin R1 receptor (GalR1) was tagged at its C terminus with EGFP (GalR1–EGFP) to study receptor localization and trafficking. In PC12 and HEK293 cells, functional GalR1–EGFP was expressed on the plasma membrane and internalized into cytoplasmic vesicles after galanin stimulation. The internalization was blocked by 0.4 M sucrose and by silencing of clathrin with siRNA methodology. Internalized GalR1–EGFP and LysoTracker, a lysosomal marker, overlapped in intracellular vesicles after prolonged galanin stimulation. This colocalization was strongly reduced after site-directed mutagenesis of the motif YXXØ on the C terminus of GalR1 (where Ø is a bulky hydrophobic residue and X any amino acid). Taken together, these data suggest that GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXØ.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Kjaer, S (2)Undo refine
Hokfelt, T (2)
Zheng, K (2)
Xu, T. (2)
Xu, ZQD (2)
Xia, S (2)
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Hu, PS (2)
Qian, Y (1)
Fredholm, B (1)
Dun, XP (1)
Solen, C (1)
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University
Karolinska Institutet (2)
Language
English (2)

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