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Sökning: WFRF:(Horie Y)

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  • Boele, Joost, et al. (författare)
  • PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
  • 2014
  • Ingår i: Proceedings of the National Academy of Sciences. - : National Acad Sciences. - 1091-6490. ; 111:31, s. 11467-11472
  • Tidskriftsartikel (refereegranskat)abstract
    • Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt at their 3' end, and moreover that the 3' end of miR-21 is posttranscriptionally adenylated by the noncanonical poly(A) polymerase PAPD5. PAPD5 knockdown caused an increase in the miR-21 expression level, suggesting that PAPD5-mediated adenylation of miR-21 leads to its degradation. Exoribonuclease knockdown experiments followed by small-RNA sequencing suggested that PARN degrades miR-21 in the 3'-to-5' direction. In accordance with this model, microarray expression profiling demonstrated that PAPD5 knockdown results in a down-regulation of miR-21 target mRNAs. We found that disruption of the miR-21 adenylation and degradation pathway is a general feature in tumors across a wide range of tissues, as evidenced by data from The Cancer Genome Atlas, as well as in the noncancerous proliferative disease psoriasis. We conclude that PAPD5 and PARN mediate degradation of oncogenic miRNA miR-21 through a tailing and trimming process, and that this pathway is disrupted in cancer and other proliferative diseases.
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  • Östberg, Olof, et al. (författare)
  • On the merits of ancient Chinese eye acupressure practices
  • 1992
  • Ingår i: Applied Ergonomics. - 0003-6870 .- 1872-9126. ; 23:5, s. 343-348
  • Tidskriftsartikel (refereegranskat)abstract
    • Chinese schoolchildren and adults with strenuous visual tasks routinely perform massage-and-pressure exercises on selected acupressure points around the eyes. This practice, taught by the Jing-Luo school of acupuncture for more than 4000 years, is claimed to prevent and cure myopia and other afflictions thought to result from visual close work. A four-week pilot experiment was carried out with the aim of designing a proper study on the possible short-term benefits of eye acupressure programmes. Questionnaire data revealed that the subjects did experience various eye/vision symptoms as a result of the 90 min experimental task. This could not be verified by the measurements of accommodation precision and critical flicker fusion, nor could any beneficial effects of acupressure be seen over the four experimental weeks.
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