↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Träfflista för sökning "WFRF:(Hsu Yi Hsiang) ;pers:(Ikram M. Arfan)"

Sökning: WFRF:(Hsu Yi Hsiang) > Ikram M. Arfan

Resultat 1-3 av 3

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Manousaki, Despoina, et al. (författare) Low Frequency Coding Variation in CYP2R1 has Large Effects on Vitamin D Level and Risk of Multiple Sclerosis 2017 Ingår i: Journal of Bone and Mineral Research. - 0884-0431 .- 1523-4681. ; 32:S1, s. S319-S320 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
2.	Manousaki, Despoina, et al. (författare) Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis. 2018 Ingår i: American journal of human genetics. - : Elsevier BV. - 1537-6605 .- 0002-9297. ; 103:6 Tidskriftsartikel (refereegranskat)
3.	Nielson, Carrie M., et al. (författare) Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2 2016 Ingår i: Journal of Bone and Mineral Research. - : Wiley. - 0884-0431. ; 31:12, s. 2085-2097 Tidskriftsartikel (refereegranskat)abstract Genome-wide association studies (GWASs) have revealed numerous loci for areal bone mineral density (aBMD). We completed the first GWAS meta-analysis (n=15,275) of lumbar spine volumetric BMD (vBMD) measured by quantitative computed tomography (QCT), allowing for examination of the trabecular bone compartment. SNPs that were significantly associated with vBMD were also examined in two GWAS meta-analyses to determine associations with morphometric vertebral fracture (n=21,701) and clinical vertebral fracture (n=5893). Expression quantitative trait locus (eQTL) analyses of iliac crest biopsies were performed in 84 postmenopausal women, and murine osteoblast expression of genes implicated by eQTL or by proximity to vBMD-associated SNPs was examined. We identified significant vBMD associations with five loci, including: 1p36.12, containing WNT4 and ZBTB40; 8q24, containing TNFRSF11B; and 13q14, containing AKAP11 and TNFSF11. Two loci (5p13 and 1p36.12) also contained associations with radiographic and clinical vertebral fracture, respectively. In 5p13, rs2468531 (minor allele frequency [MAF]=3%) was associated with higher vBMD (β=0.22, p=1.9×10-8) and decreased risk of radiographic vertebral fracture (odds ratio [OR]=0.75; false discovery rate [FDR] p=0.01). In 1p36.12, rs12742784 (MAF=21%) was associated with higher vBMD (β=0.09, p=1.2×10-10) and decreased risk of clinical vertebral fracture (OR=0.82; FDR p=7.4×10-4). Both SNPs are noncoding and were associated with increased mRNA expression levels in human bone biopsies: rs2468531 with SLC1A3 (β=0.28, FDR p=0.01, involved in glutamate signaling and osteogenic response to mechanical loading) and rs12742784 with EPHB2 (β=0.12, FDR p=1.7×10-3, functions in bone-related ephrin signaling). Both genes are expressed in murine osteoblasts. This is the first study to link SLC1A3 and EPHB2 to clinically relevant vertebral osteoporosis phenotypes. These results may help elucidate vertebral bone biology and novel approaches to reducing vertebral fracture incidence.

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-3 av 3

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (2); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Ikram, M. Arfan (3)Ta bort avgränsningen; Hsu, Yi-Hsiang (3); Rivadeneira, Fernand ... (3); Karasik, David (3); Liu, Ching-Ti (3); Karlsson, Magnus (2); visa fler...; Vandenput, Liesbeth, ... (2); Lind, Lars (2); Ohlsson, Claes, 1965 (2); Melhus, Håkan (2); Mellström, Dan, 1945 (2); Broer, Linda (2); Voortman, Trudy (2); Kiel, Douglas P. (2); Orwoll, Eric S. (2); Taylor, Bruce (2); den Heijer, Martin (2); Medina-Gomez, Caroli ... (2); Kestenbaum, Bryan (2); Tiemeier, Henning (2); Mook-Kanamori, Denni ... (2); Lorentzon, Mattias, ... (1); Nethander, Maria, 19 ... (1); Karlsson, Magnus K. (1); Rotter, Jerome I. (1); Michaëlsson, Karl, 1 ... (1); Michaëlsson, Karl (1); Zillikens, M. Carola (1); Harris, Tamara B (1); Psaty, Bruce M (1); Gudnason, Vilmundur (1); Franco, Oscar H. (1); Cupples, L. Adrienne (1); Psaty, Bruce (1); Richards, J Brent (1); de Groot, Lisette C. ... (1); Timpson, Nicholas J. (1); Mitchell, Jonathan (1); Lang, Thomas (1); Wang, Thomas J (1); Smith, Albert V (1); Parimi, Neeta (1); Robinson-Cohen, Cass ... (1); Raffield, Laura (1); Ohlsson, Claes (1); Mellstrom, Dan (1); Timpson, Nicholas (1); Rosendaal, Frits R. (1); Allison, Matthew A. (1); Criqui, Michael H. (1); visa färre...

Lärosäte: Göteborgs universitet (2); Uppsala universitet (1); Lunds universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy