SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Hu Howard) "

Sökning: WFRF:(Hu Howard)

  • Resultat 1-10 av 320
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  •  
2.
  • Wang, Zhaoming, et al. (författare)
  • Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
  • 2014
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 23:24, s. 6616-6633
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.
  •  
3.
  • Aad, G, et al. (författare)
  • 2015
  • swepub:Mat__t
  •  
4.
  • Aad, G., et al. (författare)
  • 2015
  • Ingår i: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :8
  • Tidskriftsartikel (refereegranskat)
  •  
5.
  •  
6.
  •  
7.
  •  
8.
  •  
9.
  • Aad, G, et al. (författare)
  • Determination of spin and parity of the Higgs boson in the [Formula: see text] decay channel with the ATLAS detector.
  • 2015
  • Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 75:5
  • Tidskriftsartikel (refereegranskat)abstract
    • Studies of the spin and parity quantum numbers of the Higgs boson in the [Formula: see text] final state are presented, based on proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb[Formula: see text] at a centre-of-mass energy of [Formula: see text] TeV. The Standard Model spin-parity [Formula: see text] hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even ([Formula: see text]) or CP-odd ([Formula: see text]) Higgs boson in scenarios beyond the Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-10 av 320
Typ av publikation
tidskriftsartikel (311)
forskningsöversikt (3)
konferensbidrag (1)
Typ av innehåll
refereegranskat (316)
Författare/redaktör
Hughes, G. (287)
Ferrer, A. (286)
Asai, S. (285)
Barklow, T. (285)
Bella, G. (285)
Benekos, N. (285)
visa fler...
Bugge, L. (285)
Chen, X. (285)
Clark, A. (285)
Cowan, G. (285)
Cranmer, K. (285)
Davies, M. (285)
Desch, K. (285)
Eigen, G. (285)
Elsing, M. (285)
Etzion, E. (285)
Fleck, I. (285)
Fox, H. (285)
Gross, E. (285)
Hasegawa, Y. (285)
Jackson, P. (285)
Jakobs, K. (285)
Jones, G. (285)
Kawagoe, K. (285)
Kobayashi, T. (285)
Leitner, R. (285)
Liebig, W. (285)
Lucotte, A. (285)
Mohr, W. (285)
Morii, M. (285)
Nagai, K. (285)
Oh, A. (285)
Ouraou, A. (285)
Pallin, D. (285)
Quadt, A. (285)
Rembser, C. (285)
Ros, E. (285)
Saleem, M. (285)
Salt, J. (285)
Sobie, R. (285)
Stugu, B. (285)
Su, D. (285)
Tanaka, R. (285)
Tanaka, S. (285)
Tarem, S. (285)
Tasevsky, M. (285)
Trefzger, T. (285)
Ueda, I. (285)
Vachon, B. (285)
Vlachos, S. (285)
visa färre...
Lärosäte
Lunds universitet (291)
Uppsala universitet (271)
Stockholms universitet (270)
Kungliga Tekniska Högskolan (262)
Karolinska Institutet (15)
Göteborgs universitet (11)
visa fler...
Umeå universitet (9)
Linköpings universitet (4)
Sveriges Lantbruksuniversitet (4)
Mittuniversitetet (3)
Chalmers tekniska högskola (3)
Högskolan Dalarna (3)
Högskolan i Halmstad (1)
visa färre...
Språk
Engelska (320)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (294)
Medicin och hälsovetenskap (23)
Teknik (1)
Lantbruksvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy