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- He, YQ, et al.
(author)
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A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- 2022
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966-
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Journal article (peer-reviewed)abstract
- Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
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- Johansson, Emma, et al.
(author)
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Organic chlorine and chloride in submerged paddy soil : a case study in Anhui province, southeast China
- 2004
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In: Soil use and management. - 0266-0032 .- 1475-2743. ; 20:2, s. 144-149
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Journal article (peer-reviewed)abstract
- Efforts to understand the fate of organochlorine compounds in arable soil have concentrated on anthropogenic compounds, in spite of the fact that organochlorine compounds are both produced and mineralized in soil through natural processes. In order to understand the fate of chlorinated pesticides, it is necessary to take account of the natural chlorine cycle. The present study is a first attempt to illuminate the relationship between the natural chlorine cycle and agricultural practices. The concentration and storage of organic chlorine (Cl-org) and chloride (Cl-inorg) were determined in topsoil of a paddy field compared to an adjacent afforested hill at a sampling site in the Meicun area, Anhui Province, China. The concentration of Cl-org, as well as the chlorine-to-carbon ratio, was significantly lower in the paddy field samples than in the forest soil samples. A weak relationship between the concentration of Cl-org and the organic carbon content was observed in the paddy field, in contrast to the observations made in the adjacent forest soil as well as those made in previous studies, which have suggested a positive correlation between organic carbon content and Cl-org. The similarity between our results at the forest site and the previous studies, which have been carried out in temperate regions, suggests that it is the land use rather than the climate that makes the current paddy soil results different. Our results suggest that the contribution of Cl-org to the paddy soil from above-ground litter and from production within the soil are small or negligible compared with the contribution from pesticide application and wet and dry deposition.
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