| 1. |
- Huang, Pan, et al.
(författare)
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The ERK1/2 Signaling Pathway Is Involved in Sulfur Dioxide Preconditioning-Induced Protection against Cardiac Dysfunction in Isolated Perfused Rat Heart Subjected to Myocardial Ischemia/Reperfusion
- 2013
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 14:11, s. 22190-22201
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Tidskriftsartikel (refereegranskat)abstract
- Ischemia/reperfusion injury (IRI) occurs frequently during reperfusion of ischemic myocardium, and preconditioning has been regarded as one of the best strategies to prevent myocardial injury during the ischemia/reperfusion process. Our previous studies indicated that a small dose of sulfur dioxide (SO2) used as preconditioning exerts cardioprotection. However, the mechanisms underlying the cardioprotection remain unclear. The present study was designed to examine if the extracellular regulated protein kinases 1/2 (ERK1/2) signaling pathway mediated protection against cardiac dysfunction after SO2 preconditioning in isolated rat hearts subjected to ischemia/reperfusion (I/R). Langendorff heart perfusion was performed in vitro, where 56 male Wistar rats were randomly divided into seven groups: control group, 5 mol/L SO2 group (S5), 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one (PD98059) + 5 mol/L SO2 (PD98059 + S5) group, PD98059 group, I/R group, 5 mol/L SO2 + I/R (S5 + I/R) group and PD98059 + 5 mol/L SO2 + I/R (PD98059 + S5 + I/R) group. Cardiac function and myocardial phosphorylated ERK1/2 protein were measured. We found that I/R in isolated rat heart resulted in cardiac dysfunction with a significant increase in phosphorylated ERK1/2 protein. SO2 preconditioning markedly suppressed phosphorylated ERK1/2 protein and improved cardiac function in isolated rat heart with I/R (p less than 0.05). However, pre-treatment with PD98059 could prevent the above effects of SO2 preconditioning. In conclusion, SO2 preconditioning protected against cardiac dysfunction in isolated rat heart subjected to I/R via suppression of the over-activation of the ERK1/2 signaling pathway.
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| 2. |
- Abelev, Betty, et al.
(författare)
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Underlying Event measurements in pp collisions at root s=0.9 and 7 TeV with the ALICE experiment at the LHC
- 2012
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Ingår i: Journal of High Energy Physics. - 1029-8479. ; :7
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Tidskriftsartikel (refereegranskat)abstract
- We present measurements of Underlying Event observables in pp collisions at root s = 0 : 9 and 7 TeV. The analysis is performed as a function of the highest charged-particle transverse momentum p(T),L-T in the event. Different regions are defined with respect to the azimuthal direction of the leading (highest transverse momentum) track: Toward, Transverse and Away. The Toward and Away regions collect the fragmentation products of the hardest partonic interaction. The Transverse region is expected to be most sensitive to the Underlying Event activity. The study is performed with charged particles above three different p(T) thresholds: 0.15, 0.5 and 1.0 GeV/c. In the Transverse region we observe an increase in the multiplicity of a factor 2-3 between the lower and higher collision energies, depending on the track p(T) threshold considered. Data are compared to PYTHIA 6.4, PYTHIA 8.1 and PHOJET. On average, all models considered underestimate the multiplicity and summed p(T) in the Transverse region by about 10-30%.
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| 3. |
- Huang, Xiaomei, et al.
(författare)
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A Survey of Context-Aware Recommendation Schemes in Event-Based Social Networks
- 2020
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Ingår i: Electronics. - : MDPI. - 2079-9292. ; 9:10
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Tidskriftsartikel (refereegranskat)abstract
- In recent years, Event-based social network (EBSN) applications, such as Meetup and DoubanEvent, have received popularity and rapid growth. They provide convenient online platforms for users to create, publish, and organize social events, which will be held in physical places. Additionally, they not only support typical online social networking facilities (e.g., sharing comments and photos), but also promote face-to-face offline social interactions. To provide better service for users, Context-Aware Recommender Systems (CARS) in EBSNs have recently been singled out as a fascinating area of research. CARS in EBSNs provide the suitable recommendation to target users by incorporating the contextual factors into the recommendation process. This paper provides an overview on the development of CARS in EBSNs. We begin by illustrating the concept of the term context and the paradigms of conventional context-aware recommendation process. Subsequently, we introduce the formal definition of an EBSN, the characteristics of EBSNs, the challenges that are faced by CARS in EBSNs, and the implementation process of CARS in EBSNs. We also investigate which contextual factors are considered and how they are represented in the recommendation process. Next, we focus on the state-of-the-art computational techniques regarding CARS in EBSNs. We also overview the datasets and evaluation metrics for evaluation in this research area, and discuss the applications of context-aware recommendation in EBSNs. Finally, we point out research opportunities for the research community.
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