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Circulating antimül...
Circulating antimüllerian hormone and steroid hormone levels remain high in pregnant women with polycystic ovary syndrome at term
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- Piltonen, Terhi T. (author)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland
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- Giacobini, Paolo (author)
- INSERM, Jean Pierre Aubert Res Ctr, Lab Dev & Plast Neuroendocrine Brain, Lille, France;Univ Lille, Sch Med, Federat Hosp Univ, Lille, France
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- Edvinsson, Åsa, 1982- (author)
- Uppsala universitet,Reproduktiv hälsa
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- Hustad, Steinar (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway;Univ Bergen, Core Facil Metabol, Bergen, Norway
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- Lager, Susanne (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Morin-Papunen, Laure (author)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland
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- Tapanainen, Juha S. (author)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland;Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland;Helsinki Univ Cent Hosp, Helsinki, Finland
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- Sundström-Poromaa, Inger, 1964- (author)
- Uppsala universitet,Reproduktiv hälsa
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- Arffman, Riikka K. (author)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynecol, PEDEGO Res Unit,Med Res Ctr, Aapistie 5,Box 5000, Oulu 90014, Finland
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(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
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In: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 111:3, s. 588-596.e1
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://www.fertstert...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To investigate plasma antimullerian hormone (AMH) concentration and its relation to steroid hormone levels in pregnant women with polycystic ovary syndrome (PCOS) and controls at term.Design: Case-control study.Setting: University-affiliated hospital.Patient(s): A total of 74 pregnant women at term: 25 women with PCOS (aged 31.6 ± 3.9 years [mean ± standard deviation], body mass index 24.0 ± 3.9 kg/m2, mean gestational length 279 ± 9 days) and 49 controls (aged 31.7 ± 3.3 years, body mass index 24.0 ± 3.3 kg/m2, mean gestational length 281 ± 9 days).Intervention(s): None.Main Outcome Measure(s): Plasma AMH and steroid hormone levels.Result(s): Antimullerian hormone, T, and androstenedione levels were higher in women with PCOS at term compared with controls, whereas estrogen and P levels were similar. The differences were pronounced in women carrying a female fetus. Testosterone and AMH levels correlated positively in both groups, but E2 levels only in women with PCOS.Conclusion(s): Pregnant women with PCOS present with elevated AMH and androgen levels even at term, suggesting a hormonal imbalance during PCOS pregnancy. Differences were detected especially in pregnancies with a female fetus, raising the question of whether female pregnancies are more susceptible to AMH and steroid hormone actions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- Antimullerian hormone
- androgens
- polycystic ovary syndrome
- pregnancy
Publication and Content Type
- ref (subject category)
- art (subject category)
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