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Numrering	Referens	Omslagsbild	Hitta
1.	Ridker, PM, et al. (författare) Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients 2017 Ingår i: The New England journal of medicine. - 1533-4406 .- 0028-4793. ; 376:16, s. 1527-1539 Tidskriftsartikel (refereegranskat)
2.	Al-Qahtani, SM, et al. (författare) Implementation of methylation array-based classification of paediatric central nervous system tumours in routine diagnostic pathology 2018 Ingår i: VIRCHOWS ARCHIV. - 0945-6317. ; 473, s. S26-S26 Konferensbidrag (övrigt vetenskapligt/konstnärligt)
3.	Botusan, I. R., et al. (författare) Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate 2018 Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 13:3 Tidskriftsartikel (refereegranskat)abstract Objective: IGF-I is a growth factor, which is expressed in virtually all tissues. The circulating IGF-I is however derived mainly from the liver. IGF-I promotes wound healing and its levels are decreased in wounds with low regenerative potential such as diabetic wounds. However, the contribution of circulating IGF-I to wound healing is unknown. Here we investigated the role of systemic IGF-I on wound healing rate in mice with deficiency of liver-derived IGF-I (LI-IGF-I-/- mice) during normal (normoglycemic) and impaired wound healing (diabetes). Methods: LI-IGF-I-/- mice with complete inactivation of the IGF-I gene in the hepatocytes were generated using the Cre/loxP recombination system. This resulted in a 75% reduction of circulating IGF-I. Diabetes was induced with streptozocin in both LI-IGF-I-/- and control mice. Wounds were made on the dorsum of the mice, and the wound healing rate and histology were evaluated. Serum IGF-I and GH were measured by RIA and ELISA respectively. The expression of IGF-I, IGF-II and the IGF-I receptor in the skin were evaluated by qRT-PCR. The local IGF-I protein expression in different cell types of the wounds during wound healing process was analyzed using immunohistochemistry. Results: The wound healing rate was similar in LI-IGF-I-/- mice to that in controls. Diabetes significantly delayed the wound healing rate in both LI-IGF-I-/- and control mice. However, no significant difference was observed between diabetic animals with normal or reduced hepatic IGF-I production. The gene expression of IGF-I, IGF-II and IGF-I receptor in skin was not different between any group of animals tested. Local IGF-I levels in the wounds were similar between of LI-IGF-I-/- and WT mice although a transient reduction of IGF-I expression in leukocytes in the wounds of LI-IGF-I-/- was observed seven days post wounding. Conclusion: Deficiency in the liver-derived IGF-I does not affect wound healing in mice, neither in normo-glycemic conditions nor in diabetes.

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Typ av publikation: tidskriftsartikel (2); konferensbidrag (1)

Typ av innehåll: refereegranskat (2); övrigt vetenskapligt/konstnärligt (1)

Författare/redaktör: Jackson, B. (1); Li, S. (1); Li, Y. (1); Price, D. (1); Schmidt, E. (1); Solar, M. (1); visa fler...; Zhang, L. (1); Zhang, X. (1); Zhu, Y. (1); Zhao, Y. (1); Zhou, C. (1); Zhou, Y. (1); Ahmad, A. (1); Li, J. (1); Miller, M. (1); Albert, M (1); Zhang, Y. (1); Ma, Y. (1); Sharma, S. (1); Martin, S. (1); Johnson, M. (1); Mukherjee, A. (1); Li, D. (1); Wang, D. (1); Wang, Y. (1); Yoon, J. (1); Nguyen, T. (1); Kim, K. (1); Weiss, R. (1); Smith, P. (1); Lee, S (1); Williams, M (1); Klein, G (1); Brenner, H (1); Chang, AR (1); Cohen, AJ (1); Saxena, S (1); Sharma, R (1); Yang, P. (1); Yang, X. (1); Chen, J. (1); He, Y. (1); Demin, A (1); Konstantinov, V. (1); Szilagyi, I (1); van Royen, N (1); Katz, A. (1); Vincent, S. (1); Jiang, J. (1); Schmidt, U. (1); visa färre...

Lärosäte: Karolinska Institutet (3); Göteborgs universitet (1); Lunds universitet (1)

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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