| 1. |
- Ingelsson, Erik, et al.
(author)
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Genome-wide association studies (GWAS) of adiposity
- 2016
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In: The Genetics of Type 2 Diabetes and Related Traits. - Cham : Springer Publishing Company. - 9783319015743 - 9783319015736 ; , s. 91-109
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Book chapter (peer-reviewed)abstract
- Adiposity is strongly heritable and one of the leading risk factors for type 2 diabetes, cardiovascular disease, cancer, and premature death. In the past 8 years, genome-wide association studies (GWAS) have greatly increased our understanding of the genes and biological pathways that regulate adiposity by identifying more than 100 novel susceptibility loci for overall adiposity and more than 70 loci for body fat distribution. The results for overall adiposity highlight a significant neuronal component, whereas loci regulating body fat distribution demonstrate a central role for adipocyte biology and insulin resistance in the pathophysiology. The effect sizes of all identified loci are small, and even in aggregate, they explain <3 % of the variance in each adiposity trait. This and other evidence suggest that numerous new loci will be identified in extended meta-analyses in the future. The translation of the new discoveries into clinical care remains a major challenge. As the first step, further studies are required to establish the causal genes and variants and to disentangle the exact physiological mechanisms underlying each genotype-phenotype association.
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| 2. |
- Larsson, Anders, et al.
(author)
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Study on Combined Test-Data Compression and Test Planning for Testing of Modular SoCs
- 2010
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In: Design and Test Technology for Dependable Systems-on-chip. - : Information Science Publishing. - 1609602129 - 9781609602123
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Book chapter (other academic/artistic)abstract
- Designing reliable and dependable embedded systems has become increasingly important as the failure of these systems in an automotive, aerospace or nuclear application can have serious consequences.Design and Test Technology for Dependable Systems-on-Chip covers aspects of system design and efficient modelling, and also introduces various fault models and fault mechanisms associated with digital circuits integrated into System on Chip (SoC), Multi-Processor System-on Chip (MPSoC) or Network on Chip (NoC). This book provides insight into refined "classical" design and test topics and solutions for IC test technology and fault-tolerant systems.
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| 3. |
- Nikolov, Dimitar, et al.
(author)
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Optimizing Fault Tolerance for Multi-Processor System-on-Chip
- 2010
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In: Design and Test Technology for Dependable Systems-on-chip. - : Information Science Publishing. - 1609602129 - 9781609602123 ; , s. 578-
-
Book chapter (other academic/artistic)abstract
- Designing reliable and dependable embedded systems has become increasingly important as the failure of these systems in an automotive, aerospace or nuclear application can have serious consequences.Design and Test Technology for Dependable Systems-on-Chip covers aspects of system design and efficient modelling, and also introduces various fault models and fault mechanisms associated with digital circuits integrated into System on Chip (SoC), Multi-Processor System-on Chip (MPSoC) or Network on Chip (NoC). This book provides insight into refined "classical" design and test topics and solutions for IC test technology and fault-tolerant systems.
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