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  • Ahlgren, Camilla, et al. (författare)
  • Contact allergies to potential allergens in patients with oral lichen lesions
  • 2014
  • Ingår i: Clinical Oral Investigations. - : Springer. - 1432-6981 .- 1436-3771. ; 18:1, s. 227-237
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of the present controlled study was to investigate a possible relationship between contact allergies to potential allergens and oral lichen lesions. Eighty-three patients with oral lichen lesions (OLL) and control groups of age- and gender-matched dermatitis patients (DP, n = 83) and patch-tested dermatitis patients randomly selected from files (PSFF, n = 319) were included in the study. OLL and DP groups were patch-tested epicutaneously and examined intraorally. The frequencies of contact allergy to mercury and carvone were statistically higher in the OLL group than in the DP group. Surfaces of amalgam and composite restorations were statistically more frequent in the OLL group compared to the DP group. Contact allergy to nickel and colophony, the latter with a statistically significant difference, was more common in the DP group. The numerical difference found for nickel allergy was, however, not significant comparing the OLL and PSFF groups. Contact allergy to mercury was overrepresented in patients with OLL and has been reported in previous studies, but the present finding of an overrepresentation of contact allergy to carvone in patients with oral lichen lesions has not been reported previously. Carvone, in addition to mercury and gold, as previously suggested, can be one of the causative or maintenant factors for oral lichen lesions. Carvone-hypersensitive patients with oral lichen lesions should therefore avoid carvone-containing products for oral use.
  • Ahlgren, Camilla, et al. (författare)
  • The necessity of a test reading after 1 week to detect late positive patch test reactions in patients with oral lichen lesions
  • 2014
  • Ingår i: Clinical Oral Investigations. - : Springer. - 1432-6981 .- 1436-3771. ; 18:5, s. 1525-1531
  • Tidskriftsartikel (refereegranskat)abstract
    • Establishing the clinical relevance of contact allergy to dental materials in patients with oral lichen lesions (OLL) may be difficult, and tests are often read only on day 3 or day 4; also, concentration of the tested allergens may vary. Several studies on dermatitis patients have shown that additional positive patch test reactions can be found after day 4. Therefore, the aim of the present study was to analyse the frequency of late positive reactions to potential allergens in patients with OLL. Eighty-three of 96 consecutive patients with biopsy-verified OLL were patch-tested with a recently developed lichen series. The patches were removed after 48 h and reactions read 3 and 7 days after application. A total of 129 contact allergies were found, and 26 (20.2 %) of the allergic reactions in 23 patients were seen on day 7 only. The 25.2 % increase in positive test reactions with an additional reading on day 7 in addition to day 3 was statistically significant. Metals were the substances with the highest frequency of late positive reactions. Patients with OLL cannot be considered properly investigated with regard to contact allergy, unless the testing has been performed with mandatory readings on day 3 (or day 4) and day 7. Late patch test readings are crucial in order to elucidate the role of contact allergy to dental materials in the aetiology of OLL.
  • Ahrensbøll-Friis, Ulrik, et al. (författare)
  • Allergic contact dermatitis from dyes used in the temple of spectacles
  • 2022
  • Ingår i: Contact Dermatitis. - : Blackwell. - 0105-1873. ; 86:1, s. 25-28
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: We observed an increasing number of patients who presented with facial or retro-auricular dermatitis after skin contact with plastic spectacles or plastic covered temples. Objectives: To identify the allergens in plastic spectacles that may cause allergic contact dermatitis. Methods: All patients with suspected allergic contact dermatitis to eyewear were tested with Solvent Orange 60 (SO60), four additionally with Solvent Yellow 14 (SY14), and five with scrapings from their own spectacles. In one case, a chemical analysis of the spectacles was performed to uncover the causative allergen. Results: Three patients were allergic to SO60, two patients to SY14, and two patients were allergic to both SO60 and SY14. Conclusion: Patients with suspected allergic contact dermatitis from spectacles should be tested with SO60 and SY14, and based on findings from previous reports, also with Solvent Red 179.
  • Anveden, I, et al. (författare)
  • Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel
  • 2004
  • Ingår i: Contact Dermatitis. - : Blackwell. - 0105-1873. ; 50:5, s. 298-303
  • Tidskriftsartikel (refereegranskat)abstract
    • A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested.
  • Broberg, A, et al. (författare)
  • Dead Sea extract sold under-the-counter
  • 2003
  • Ingår i: British Journal of Dermatology. - : Wiley-Blackwell. - 1365-2133. ; 149:1, s. 206-207
  • Tidskriftsartikel (övrigt vetenskapligt)
  • Bruze, Magnus, et al. (författare)
  • Recommendation of appropriate amounts of petrolatum preparation to be applied at patch testing.
  • 2007
  • Ingår i: Contact Dermatitis. - : Blackwell. - 0105-1873. ; 56:5, s. 281-285
  • Tidskriftsartikel (refereegranskat)abstract
    • Background: No recommendation exists on the amount of petrolatum (pet.) preparation to be applied in a Finn Chamber (R) or van der Bend Chamber. Objectives: The aim of this study was to determine the appropriate amount of pet. preparation to apply in the Finn and van der Bend chambers. Methods: 12 volunteers were patch tested with green-coloured pet. in Finn and van der Bend chambers on the back on 3 occasions. Doses were 10, 15, 20, 25, and 30 mg initially and on second and third occasion, 10 mg was removed in van der Bend Chambers and 35 mg was added. On day 2, the test sites were scored. A negative test equalled a test area not covered to 100%. A positive test meant a completely green-coloured test area. Minor and major spreading was noted. The amount of pet. preparation yielding at most 5% negative reactions and having the least number of reactions with major spreading equalled the appropriate amount. Results: For van der Bend Chambers, all doses yielded more than 5% negative reactions. For the Finn Chamber (R), 30, 25, and 20 mg pet. yielded less than 5% negative reactions and with major spreading in 60%, 40%, and 25% of test sites. Conclusions: 20 mg pet. preparation was the optimal dose for the Finn Chambers (R).
  • Bruze, Magnus, et al. (författare)
  • Variation in the amount of petrolatum preparation applied at patch testing.
  • 2007
  • Ingår i: Contact Dermatitis. - : Blackwell. - 0105-1873. ; 56:1, s. 38-42
  • Tidskriftsartikel (refereegranskat)abstract
    • The elicitation of a positive patch test reaction in a given individual depends upon the dose of the sensitizer applied, the patch test technique and the occlusion time. The dose is determined by the concentration and volume/amount of test preparation applied. If the same amount/volume of a test preparation is applied all the time with the same test technique (same area of skin) and occlusion time, it is appropriate to use concentration as a dose parameter. Most contact sensitizers are incorporated in petrolatum (pet.). With pet. as vehicle, it is impossible to repeatedly apply an exact volume/amount. This study was performed to investigate the inter- and intra-individual variation of pet. preparation applied at patch testing by 3 technicians. Weighing demonstrated that the 3 technicians had about the same precision in their pet. application. The investigation demonstrates that there is both an inter-individual (statistically significant) and intra-individual variation in the amounts of pet. applied at patch testing for the 3 technicians. Presently, there is no recommendation on what amount of pet. preparation to apply, which merits a decision to be taken based on thorough investigations on the appropriate volumes of pet. preparation to be applied in various patch test systems.
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