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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Yasuda, Kazuki (author)
Miyake, Kazuaki (author)
Horikawa, Yukio (author)
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Hara, Kazuo (author)
Osawa, Haruhiko (author)
Furuta, Hiroto (author)
Hirota, Yushi (author)
Mori, Hiroyuki (author)
Jonsson, Anna (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Sato, Yoshifumi (author)
Yamagata, Kazuya (author)
Hinokio, Yoshinori (author)
Wang, He-Yao (author)
Tanahashi, Toshihito (author)
Nakamura, Naoto (author)
Oka, Yoshitomo (author)
Iwasaki, Naoko (author)
Iwamoto, Yasuhiko (author)
Yamada, Yuichiro (author)
Seino, Yutaka (author)
Maegawa, Hiroshi (author)
Kashiwagi, Atsunori (author)
Takeda, Jun (author)
Maeda, Eiichi (author)
Shin, Hyoung Doo (author)
Cho, Young Min (author)
Park, Kyong Soo (author)
Lee, Hong Kyu (author)
Ng, Maggie C. Y. (author)
Ma, Ronald C. W. (author)
So, Wing-Yee (author)
Chan, Juliana C. N. (author)
Lyssenko, Valeriya (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Tuomi, Tiinamaija (author)
Nilsson, Peter (author)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Kamatani, Naoyuki (author)
Sekine, Akihiro (author)
Nakamura, Yusuke (author)
Yamamoto, Ken (author)
Yoshida, Teruhiko (author)
Tokunaga, Katsushi (author)
Itakura, Mitsuo (author)
Makino, Hideichi (author)
Nanjo, Kishio (author)
Kadowaki, Takashi (author)
Kasuga, Masato (author)
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 (creator_code:org_t)
2008-08-17
2008
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:9, s. 1092-1097
Related links:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We carried out a multistage genome-wide association study of type 2 diabetes mellitus in Japanese individuals, with a total of 1,612 cases and 1,424 controls and 100,000 SNPs. The most significant association was obtained with SNPs in KCNQ1, and dense mapping within the gene revealed that rs2237892 in intron 15 showed the lowest P value (6.7 x 10(-13), odds ratio (OR) = 1.49). The association of KCNQ1 with type 2 diabetes was replicated in populations of Korean, Chinese and European ancestry as well as in two independent Japanese populations, and meta-analysis with a total of 19,930 individuals (9,569 cases and 10,361 controls) yielded a P value of 1.7 x 10(-42) (OR = 1.40; 95% CI = 1.34-1.47) for rs2237892. Among control subjects, the risk allele of this polymorphism was associated with impairment of insulin secretion according to the homeostasis model assessment of beta-cell function or the corrected insulin response. Our data thus implicate KCNQ1 as a diabetes susceptibility gene in groups of different ancestries.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)

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