Search: WFRF:(Jablonski Kathleen A.)
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Physical activity a...
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
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Kilpeläinen, Tuomas O (author)
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Qi, Lu (author)
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Brage, Soren (author)
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show more...
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Sharp, Stephen J (author)
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- Sonestedt, Emily (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Demerath, Ellen (author)
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Ahmad, Tariq (author)
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Mora, Samia (author)
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Kaakinen, Marika (author)
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Sandholt, Camilla Helene (author)
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Holzapfel, Christina (author)
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Autenrieth, Christine S (author)
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Hyppönen, Elina (author)
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Cauchi, Stéphane (author)
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He, Meian (author)
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Kutalik, Zoltan (author)
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Kumari, Meena (author)
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Stančáková, Alena (author)
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Meidtner, Karina (author)
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Balkau, Beverley (author)
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Tan, Jonathan T (author)
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Mangino, Massimo (author)
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Timpson, Nicholas J (author)
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Song, Yiqing (author)
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Zillikens, M Carola (author)
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Jablonski, Kathleen A (author)
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Garcia, Melissa E (author)
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Johansson, Stefan (author)
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Bragg-Gresham, Jennifer L (author)
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Wu, Ying (author)
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van Vliet-Ostaptchouk, Jana V (author)
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Onland-Moret, N Charlotte (author)
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Zimmermann, Esther (author)
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Rivera, Natalia V (author)
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Tanaka, Toshiko (author)
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Stringham, Heather M (author)
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Silbernagel, Günther (author)
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Kanoni, Stavroula (author)
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Feitosa, Mary F (author)
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Snitker, Soren (author)
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- Ruiz, Jonatan R (author)
- Karolinska Institutet
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Metter, Jeffery (author)
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Larrad, Maria Teresa Martinez (author)
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Atalay, Mustafa (author)
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Hakanen, Maarit (author)
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Amin, Najaf (author)
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Cavalcanti-Proença, Christine (author)
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Grøntved, Anders (author)
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- Hallmans, Göran (author)
- Umeå universitet,Näringsforskning
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Kuusisto, Johanna (author)
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Kähönen, Mika (author)
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Lutsey, Pamela L (author)
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Nolan, John J (author)
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Palla, Luigi (author)
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Pedersen, Oluf (author)
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Pérusse, Louis (author)
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- Renström, Frida (author)
- Umeå universitet,Medicin
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Scott, Robert A (author)
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- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin
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Sovio, Ulla (author)
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Tammelin, Tuija H (author)
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Rönnemaa, Tapani (author)
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Lakka, Timo A (author)
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Uusitupa, Matti (author)
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Rios, Manuel Serrano (author)
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Ferrucci, Luigi (author)
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Bouchard, Claude (author)
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Meirhaeghe, Aline (author)
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Fu, Mao (author)
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Walker, Mark (author)
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Borecki, Ingrid B (author)
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Dedoussis, George V (author)
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Fritsche, Andreas (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Boehnke, Michael (author)
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Bandinelli, Stefania (author)
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van Duijn, Cornelia M (author)
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Ebrahim, Shah (author)
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Lawlor, Debbie A (author)
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Gudnason, Vilmundur (author)
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Harris, Tamara B (author)
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Sørensen, Thorkild I A (author)
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Mohlke, Karen L (author)
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Hofman, Albert (author)
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Uitterlinden, André G (author)
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Tuomilehto, Jaakko (author)
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Lehtimäki, Terho (author)
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Raitakari, Olli (author)
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Isomaa, Bo (author)
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Njølstad, Pål R (author)
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Florez, Jose C (author)
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Liu, Simin (author)
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Ness, Andy (author)
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Spector, Timothy D (author)
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Tai, E Shyong (author)
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Froguel, Philippe (author)
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Boeing, Heiner (author)
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Laakso, Markku (author)
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Marmot, Michael (author)
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Bergmann, Sven (author)
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Power, Chris (author)
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Khaw, Kay-Tee (author)
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Chasman, Daniel (author)
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Ridker, Paul (author)
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Hansen, Torben (author)
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Monda, Keri L (author)
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Illig, Thomas (author)
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Järvelin, Marjo-Riitta (author)
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Wareham, Nicholas J (author)
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Hu, Frank B (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Ekelund, Ulf (author)
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Medicin
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Loos, Ruth J F (author)
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(creator_code:org_t)
- 2011-11-01
- 2011
- English.
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In: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 8:11
- Related links:
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https://journals.plo...
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https://portal.resea... (primary) (free)
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) =0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio =1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio =1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kilpeläinen, Tuo ...
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Qi, Lu
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Brage, Soren
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Sharp, Stephen J
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Sonestedt, Emily
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Demerath, Ellen
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show more...
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Ahmad, Tariq
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Mora, Samia
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Kaakinen, Marika
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Sandholt, Camill ...
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Holzapfel, Chris ...
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Autenrieth, Chri ...
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Hyppönen, Elina
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Cauchi, Stéphane
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He, Meian
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Kutalik, Zoltan
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Kumari, Meena
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Stančáková, Alen ...
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Meidtner, Karina
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Balkau, Beverley
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Tan, Jonathan T
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Mangino, Massimo
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Timpson, Nichola ...
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Song, Yiqing
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Zillikens, M Car ...
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Jablonski, Kathl ...
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Garcia, Melissa ...
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Johansson, Stefa ...
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Bragg-Gresham, J ...
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Wu, Ying
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van Vliet-Ostapt ...
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Onland-Moret, N ...
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Zimmermann, Esth ...
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Rivera, Natalia ...
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Tanaka, Toshiko
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Stringham, Heath ...
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Silbernagel, Gün ...
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Kanoni, Stavroul ...
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Feitosa, Mary F
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Snitker, Soren
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Ruiz, Jonatan R
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Metter, Jeffery
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Larrad, Maria Te ...
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Atalay, Mustafa
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Hakanen, Maarit
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Amin, Najaf
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Cavalcanti-Proen ...
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Grøntved, Anders
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Hallmans, Göran
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Jansson, John-Ol ...
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Kuusisto, Johann ...
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Kähönen, Mika
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Lutsey, Pamela L
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Nolan, John J
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Palla, Luigi
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Pedersen, Oluf
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Pérusse, Louis
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Renström, Frida
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Scott, Robert A
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Shungin, Dmitry
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Sovio, Ulla
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Tammelin, Tuija ...
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Rönnemaa, Tapani
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Lakka, Timo A
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Uusitupa, Matti
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Rios, Manuel Ser ...
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Ferrucci, Luigi
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Bouchard, Claude
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Meirhaeghe, Alin ...
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Fu, Mao
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Walker, Mark
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Borecki, Ingrid ...
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Dedoussis, Georg ...
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Fritsche, Andrea ...
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Ohlsson, Claes, ...
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Boehnke, Michael
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Bandinelli, Stef ...
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van Duijn, Corne ...
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Ebrahim, Shah
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Lawlor, Debbie A
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Gudnason, Vilmun ...
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Harris, Tamara B
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Sørensen, Thorki ...
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Mohlke, Karen L
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Hofman, Albert
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Uitterlinden, An ...
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Tuomilehto, Jaak ...
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Lehtimäki, Terho
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Raitakari, Olli
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Isomaa, Bo
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Njølstad, Pål R
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Florez, Jose C
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Liu, Simin
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Ness, Andy
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Spector, Timothy ...
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Tai, E Shyong
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Froguel, Philipp ...
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Boeing, Heiner
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Laakso, Markku
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Marmot, Michael
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Bergmann, Sven
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Power, Chris
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Khaw, Kay-Tee
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Chasman, Daniel
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Ridker, Paul
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Hansen, Torben
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Monda, Keri L
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Illig, Thomas
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Järvelin, Marjo- ...
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Wareham, Nichola ...
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Hu, Frank B
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Groop, Leif
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Orho-Melander, M ...
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Ekelund, Ulf
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Franks, Paul
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Loos, Ruth J F
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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PLoS medicine
- By the university
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University of Gothenburg
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Lund University
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Umeå University
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Karolinska Institutet