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Träfflista för sökning "WFRF:(Jacobs KB) ;pers:(Chanock SJ)"

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Result 1-8 of 8

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1.	Chung, CC, et al. (author) Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer 2011 In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 20:14, s. 2869-2878 Journal article (peer-reviewed)
2.	Prokunina-Olsson, L, et al. (author) Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2 2010 In: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. - 1538-7755. ; 19:5, s. 1349-1355 Journal article (peer-reviewed)
3.	Randall, JC, et al. (author) Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits 2013 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 9:6, s. e1003500- Journal article (peer-reviewed)
4.	Siddiq, A, et al. (author) A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 2012 In: Human molecular genetics. - : Oxford University Press (OUP). - 1460-2083 .- 0964-6906. ; 21:24, s. 5373-5384 Journal article (peer-reviewed)
5.	Winkler, TW, et al. (author) Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 2016 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 12:6, s. e1006166- Journal article (peer-reviewed)
6.	Winkler, TW, et al. (author) The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study 2015 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 11:10, s. e1005378- Journal article (peer-reviewed)
7.	Wood, AR, et al. (author) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Journal article (peer-reviewed)
8.	Zhang, YD, et al. (author) Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers 2020 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 3353- Journal article (peer-reviewed)abstract Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree of polygenicity, involving at a minimum of thousands of loci. We project that sample sizes required to explain 80% of GWAS heritability vary from 60,000 cases for testicular to over 1,000,000 cases for lung cancer. The maximum relative risk achievable for subjects at the 99th risk percentile of underlying polygenic risk scores (PRS), compared to average risk, ranges from 12 for testicular to 2.5 for ovarian cancer. We show that PRS have potential for risk stratification for cancers of breast, colon and prostate, but less so for others because of modest heritability and lower incidence.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (8)

Author/Editor: Chanock, SJ (8)Undo refine; Berndt, SI (7); Hall, P (6); Hveem, K (6); Hunter, DJ (6); Gronberg, H (6); show more...; Montgomery, GW (5); Uitterlinden, AG (5); Martin, NG (5); Haiman, CA (5); Rivadeneira, F (5); Wang, ZM (5); Schumacher, FR (5); Erdmann, J. (4); Peters, A (4); Sinisalo, J. (4); Kivimaki, M (4); Langenberg, C. (4); Boomsma, DI (4); Pedersen, NL (4); van Duijn, CM (4); Yang, J. (4); Loos, RJF (4); Lorentzon, Mattias, ... (4); Fischer, K. (4); Albrecht, E (4); Smith, AV (4); Teumer, A (4); Hofman, A (4); Volzke, H (4); Ohlsson, Claes, 1965 (4); Lindstrom, J (4); Froguel, P (4); Kanoni, S (4); Nolte, IM (4); Feitosa, MF (4); Hamsten, A (4); Kumari, M (4); Dedoussis, G. (4); Grallert, H. (4); Muller-Nurasyid, M. (4); Deloukas, P. (4); Kutalik, Z. (4); Lehtimaki, T. (4); Snieder, H. (4); Tuomilehto, J. (4); Kraft, P (4); Campbell, H (4); de Faire, U (4); Virtamo, J (4); show less...

University: Karolinska Institutet (8); Umeå University (5); University of Gothenburg (4); Uppsala University (4); Lund University (3); Högskolan Dalarna (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (6)

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