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Sökning: WFRF:(Jakobsson Mattias) > Licentiatavhandling

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1.
  • Ausmees, Kristiina (författare)
  • Efficient computational methods for applications in genomics
  • 2019
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • During the last two decades, advances in molecular technology have facilitated the sequencing and analysis of ancient DNA recovered from archaeological finds, contributing to novel insights into human evolutionary history. As more ancient genetic information has become available, the need for specialized methods of analysis has also increased. In this thesis, we investigate statistical and computational models for analysis of genetic data, with a particular focus on the context of ancient DNA.The main focus is on imputation, or the inference of missing genotypes based on observed sequence data. We present results from a systematic evaluation of a common imputation pipeline on empirical ancient samples, and show that imputed data can constitute a realistic option for population-genetic analyses. We also discuss preliminary results from a simulation study comparing two methods of phasing and imputation, which suggest that the parametric Li and Stephens framework may be more robust to extremely low levels of sparsity than the parsimonious Browning and Browning model.An evaluation of methods to handle missing data in the application of PCA for dimensionality reduction of genotype data is also presented. We illustrate that non-overlapping sequence data can lead to artifacts in projected scores, and evaluate different methods for handling unobserved genotypes.In genomics, as in other fields of research, increasing sizes of data sets are placing larger demands on efficient data management and compute infrastructures. The last part of this thesis addresses the use of cloud resources for facilitating such analysis. We present two different cloud-based solutions, and exemplify them on applications from genomics.
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2.
  • Jakobsson, Erik, 1987- (författare)
  • Data-driven Condition Monitoring in Mining Vehicles
  • 2019
  • Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Situation awareness is a crucial capability of any autonomous system, including mining vehicles such as drill rigs and mine trucks. Typically situation awareness is interpreted as the capability of an autonomous system to interpret its surroundings and the intentions of other agents. The internal system awareness however, is often not receiving the same focus, even though the success of any given mission is completely dependent of the condition of the agents themselves. The internal system awareness in the form of vehicle health is the focus of this thesis.As the mining industry becomes increasingly automated, and vehicles become increasingly advanced, the need for condition monitoring and prognostics will continue to rise. This thesis explores data-driven methods that estimate the health of mining vehicles to accommodate those needs. We do so by utilizing available sensor signals, common on a large amount of mining vehicles, to make assessments of the current vehicle condition and tasks. The mining industry is characterized by small series of highly specialized vehicles, which affects the possibility to use more traditional prognostic solutions.The resulting health information can be used both to aid in tasks such as maintenance planning, but also as an important input to decision making for the planning system, i.e. how to run the vehicle for minimum wear and damage, while maintaining other mission objectives.The contributions include: a) A method to use operational data to estimate damage on the frame of a mine truck. This is done using system identification to find a model describing stresses in the structure with input from other sensors such as accelerometers, load sensors and pressure sensors. The estimated stress time signal is in turn used to calculate accumulated damage, and is shown to reveal interesting conclusions on driver behavior. b) A method to characterize the different driving tasks by using an accelerometer and a convolutional neural network. We show that the model is capable of classifying the vehicle task correctly in 96 % of the cases. And finally c), a system for underground road monitoring, where a quarter car model and a Kalman filter are used to generate an estimate of the road profile, while positioning the vehicle using inertial measurements and access point signal strength.
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