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Träfflista för sökning "WFRF:(Janson Christer) ;pers:(Janson Jan Christer)"

Sökning: WFRF:(Janson Christer) > Janson Jan Christer

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1.
  • Ali, M. A. E., et al. (författare)
  • Antimicrobial potential of Saccharomyces boulardii extracts and fractions
  • 2012
  • Ingår i: Journal of Applied Sciences Research. - 1816-157X .- 1819-544X. ; 8:8, s. 4537-4543
  • Tidskriftsartikel (refereegranskat)abstract
    • Different extracts of viable therapeutic Saccharomyces boulardii cells were evaluated for their antimicrobial activities against Escherichia coli and Candida albicans. Water, methanol, isopropanol, n-butanol and ethanol were used as solvents for extraction. Ethanol-extract exhibited the highest antimicrobial activity towards both strains, followed by water-extract. No antimicrobial activity could be detected on testing methanol-extract towards both strains. Ethanol- and water-extracts, cells remaining after water and ethanol extraction and broth were also tested for their antimicrobial activities against Gram-positive, Gram-negative, non-filamentous and filamentous fungi and showed considerable amounts of antimicrobial activities. Ethanol extracts exhibited the highest antimicrobial activity against all the tested strains, was then fractionated on a Sephadex G-100 column and the obtained fractions were examined using the agar-well diffusion method against Staphylococcus aureus, E.coli, C. albicans and Aspergillus niger. Results obtained indicate the presence of different scattered active fractions with different potencies against the four tested microorganisms. A large scale fermentation process was conducted using a BioFlo benchtop-15L Fermentor/ Bioreactor and the products were evaluated for their antimicrobial activities.
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2.
  • Andersson, Mikael, 1964- (författare)
  • Characterisation of Chromatography Media Aimed for Purification of Biomolecules
  • 2014
  • Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
    • Chromatography media (resins) are very important for and widely used by the biopharma industry in large scale production of biopharmaceuticals, e.g. monoclonal antibodies. Today there are several hundred biopharmaceuticals released globally on the healthcare market. This thesis discusses various strategies and methods for the characterisation of chemical and functional stability of chromatography media. In addition, various analytical techniques used in these areas were evaluated and applied. Further, more specific physical and chemical characterisation methods were evaluated and applied to explore different properties of various chromatography media.In Papers I-III, established methodologies for performing chemical and functional stability studies were used. Mainly agarose-based chromatography media were investigated. For fast screening of the chemical stability, the total organic carbon analysis technique was evaluated and applied. This technique that measures the carbon leakage from the chromatography media at different conditions, proved to be very suitable and robust. For detection and/or identification of leakage compounds responsible for or for part of the measured carbon leakage, different methods such as (high performance) liquid chromatography and gas chromatography mass spectrometry were used.In Papers IV-VII, different properties (i.e. functional performance, ligand content and surface chemistry) were evaluated for different agarose-based chromatography media. Standard chromatographic methods (ion exchange chromatography) and spectroscopic methods (e.g. Fourier transform infrared spectroscopy and time-of-flight secondary ion mass spectrometry) were evaluated and applied. Chemometric methods were used for efficient evaluation of data.Information of chemical, functional and leakage data of chromatography media are valuable and important for the biopharmaceutical companies to be able to fulfil the regulatory requirements of biopharmaceuticals. In addition, information of various chemical, functional and physical properties of chromatography media is likewise important during development and set up of new biopharmaceutical processes.
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3.
  • Batista-Viera, F, et al. (författare)
  • Affinity chromatography
  • 2011. - 3
  • Ingår i: Protein Purification, Principles, High Resolution Methods and Applications. - : John Wiley & Sons Inc.. - 9780471746614 ; , s. 221-258
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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4.
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5.
  • Caldwell, Karin D., et al. (författare)
  • The Origin of Sepahdex
  • 2006
  • Ingår i: GIT Laboratory Journal: Europe. ; 10:5, s. 18-20
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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6.
  • Choulier, Laurence, et al. (författare)
  • Delineation of a linear epitope by multiple peptide synthesis and phage display
  • 2001
  • Ingår i: JOURNAL OF IMMUNOLOGICAL METHODS. - : ELSEVIER SCIENCE BV. - 0022-1759. ; 249:1-2, s. 253-264
  • Tidskriftsartikel (refereegranskat)abstract
    • Two different approaches, the phage display technique and the Spot peptide synthesis on cellulose membranes, were used to identify sequences recognized by Fab 57P specific for tobacco mosaic virus protein (TMVP), and define the preferred chemical composit
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7.
  • Ersson, B, et al. (författare)
  • Introduction to protein purification
  • 2011. - 3
  • Ingår i: Protein Purification, Principles, High Resolution Methods and Applications. - : John Wiley & Sons Inc.. - 9780471746614 ; , s. 3-22
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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8.
  • Gao, Min, et al. (författare)
  • Separation of polyphenols using porous polyamide resin and assessment of mechanism of retention
  • 2011
  • Ingår i: Journal of Separation Science. - : Wiley. - 1615-9306 .- 1615-9314. ; 34:15, s. 1853-1858
  • Tidskriftsartikel (refereegranskat)abstract
    • A porous polyamide resin is shown to possess hydrogen bond acceptor properties suitable for the separation of polyphenolic solutes such as phenolic acids, flavonols and flavonoids. The separation is achieved in the presence of solvent mixtures of acetic acid and ethanol. The extent of hydrogen bond adsorption is reviewed based on data obtained from the elution behaviour of a variety of simple polyphenolic solutes. Polyamide adsorption chromatography was applied for the purification of resveratrol and polydatin from Polygonum cuspidatum Sieb. & Zucc.
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9.
  • Gu, M., et al. (författare)
  • One-step purification of resveratrol and polydatin from Polygonum cuspidatum (Sieb. & Zucc.) by isocratic hydrogen bond adsorption chromatography on cross-linked 12% agarose
  • 2006
  • Ingår i: Chromatographia. - : Springer Science and Business Media LLC. - 0009-5893 .- 1612-1112. ; 64:11-12, s. 701-704
  • Tidskriftsartikel (refereegranskat)abstract
    • Resveratrol and polydatin (piceid), the major active components of the traditional Chinese medicinal herb Polygonum cuspidatum (Sieb. & Zucc.), have been separated and purified from crude root extracts in one step by isocratic hydrogen bond adsorption chromatography on cross-linked 12% agarose (Superose™ 12 HR 10/30). Separation was achieved by step-wise elution with mobile phases composed of mixtures of ethanol and acetic acid: 0–75 mL, 10% ethanol, 10% acetic acid; 75–150 mL, 20% ethanol, 20% acetic acid; 150–250 mL, 30% ethanol, 30% acetic acid. At a sample load of 40 mg crude extract dissolved in 0.5 mL mobile phase (corresponding to a load of 1.7 mg mL−1 gel) a resveratrol purity of about 96% with a recovery of 61% was obtained by proper peak cutting.
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10.
  • Gu, M., et al. (författare)
  • The Separation of Polyphenols by Isocratic Hydrogen Bond Adsorption Chromatography on a Cross-Linked 12% Agarose Gel
  • 2006
  • Ingår i: Chromatographia. - : Springer Science and Business Media LLC. - 0009-5893 .- 1612-1112. ; 64:5-6, s. 247-253
  • Tidskriftsartikel (refereegranskat)abstract
    • The highly cross-linked 12% agarose gel, Superose™ 12 HR 10/30 is shown to possess hydrogen bond acceptor properties suitable for the separation of polyphenolic solutes such as phenolic acids, flavonols and flavonoids. The separation is achieved isocratically in the presence of solvent mixtures of acetic acid and ethanol. The extent of hydrogen bond adsorption is reviewed based on data obtained from the elution behaviour of a variety of simple polyphenolic solutes including dihydroxybenzoic acids.
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