Search: WFRF:(Jin Guangfu)
> (2020)
> Hu Zhibin >
Association Analysi...
Association Analysis of Driver Gene-Related Genetic Variants Identified Novel Lung Cancer Susceptibility Loci with 20,871 Lung Cancer Cases and 15,971 Controls
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- Wang, Yuzhuo (author)
- Nanjing Medical University,Jiangsu Cancer Hospital
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- Gorlova, Olga Y. (author)
- Baylor College of Medicine,Dartmouth College
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- Gorlov, Ivan P. (author)
- Baylor College of Medicine,Dartmouth College
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- Zhu, Meng (author)
- Nanjing Medical University,Jiangsu Cancer Hospital
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- Dai, Juncheng (author)
- Nanjing Medical University
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- Albanes, Demetrius (author)
- National Cancer Institute, USA
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- Lam, Stephen (author)
- British Columbia Cancer Agency
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- Tardon, Adonina (author)
- University of Oviedo
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- Chen, Chu (author)
- Fred Hutchinson Cancer Research Center,Harvard University,Vanderbilt University
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- Goodman, Gary E. (author)
- Swedish Medical Center
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- Bojesen, Stig E. (author)
- Copenhagen University Hospital,University of Copenhagen
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- Landi, Maria Teresa (author)
- National Cancer Institute, USA
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- Johansson, Mattias (author)
- International Agency for Research on Cancer, World Health Organization
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- Risch, Angela (author)
- University of Salzburg,German Center for Lung Research (DZL),German Cancer Research Centre
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- Wichmann, Heunz-Erich (author)
- Ludwig-Maximilian University of Munich,Helmholtz Zentrum München,Technical University of Munich
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- Bickeboller, Heike (author)
- University Medical Center Göttingen
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Christiani, David C. (author)
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- Rennert, Gad (author)
- Technion - Israel Institute of Technology
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- Arnold, Susanne M. (author)
- University of Kentucky
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- Brennan, Paul (author)
- International Agency for Research on Cancer, World Health Organization
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- Field, John K. (author)
- University of Liverpool
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- Shete, Sanjay (author)
- University of Texas MD Anderson Cancer Center,Dartmouth-Hitchcock Medical Center
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- Le Marchand, Loic (author)
- University of Hawai'i at Hilo
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital
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- Brunnstrom, Hans (author)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Liu, Geoffrey (author)
- Princess Margaret Hospital University of Toronto
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- Hung, Rayjean J. (author)
- Sinai Health System
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Andrew, Angeline S. (author)
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- Kiemeney, Lambertus A. (author)
- Radboud University Medical Center
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- Zienolddiny, Shanbeh (author)
- National Institute of Occupational Health, Norway
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- Grankvist, Kjell (author)
- Umeå University,Umeå universitet,Klinisk kemi
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- Johansson, Mikael (author)
- Umeå University,Umeå universitet,Onkologi
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- Caporaso, Neil E. (author)
- National Cancer Institute, USA
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- Woll, Penella J. (author)
- University of Sheffield
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- Lazarus, Philip (author)
- Washington State University
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- Schabath, Matthew B. (author)
- H. Lee Moffitt Cancer Center & Research Institute
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Aldrich, Melinda C. (author)
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- Stevens, Victoria L. (author)
- American Cancer Society
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- Ma, Hongxia (author)
- Nanjing Medical University
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- Jin, Guangfu (author)
- Nanjing Medical University
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- Hu, Zhibin (author)
- Nanjing Medical University
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- Amos, Christopher I. (author)
- Baylor College of Medicine
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- Shen, Hongbing (author)
- Nanjing Medical University
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(creator_code:org_t)
- American Association for Cancer Research, 2020
- 2020
- English.
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In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 29:7, s. 1423-1429
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- Background: A substantial proportion of cancer driver genes (CDG) are also cancer predisposition genes. However, the associations between genetic variants in lung CDGs and the susceptibility to lung cancer have rarely been investigated.Methods: We selected expression-related single-nucleotide polymorphisms (eSNP) and nonsynonymous variants of lung CDGs, and tested their associations with lung cancer risk in two large-scale genome-wide association studies (20,871 cases and 15,971 controls of European descent). Conditional and joint association analysis was performed to identify independent risk variants. The associations of independent risk variants with somatic alterations in lung CDGs or recurrently altered pathways were investigated using data from The Cancer Genome Atlas (TCGA) project.Results: We identified seven independent SNPs in five lung CDGs that were consistently associated with lung cancer risk in discovery (P < 0.001) and validation (P < 0.05) stages. Among these loci, rs78062588 in TPM3 (1q21.3) was a new lung cancer susceptibility locus (OR = 0.86, P = 1.65 x 10(-6)). Subgroup analysis by histologic types further identified nine lung CDGs. Analysis of somatic alterations found that in lung adenocarcinomas, rs78062588[C] allele (TPM3 in 1q21.3) was associated with elevated somatic copy number of TPM3 (OR = 1.16, P = 0.02). In lung adenocarcinomas, rs1611182 (HLA-A in 6p22.1) was associated with truncation mutations of the transcriptional misregulation in cancer pathway (OR = 0.66, P = 1.76 x 10(-3)).Conclusions: Genetic variants can regulate functions of lung CDGs and influence lung cancer susceptibility. Impact: Our findings might help unravel biological mechanisms underlying lung cancer susceptibility.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wang, Yuzhuo
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Gorlova, Olga Y.
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Gorlov, Ivan P.
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Zhu, Meng
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Dai, Juncheng
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Albanes, Demetri ...
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show more...
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Lam, Stephen
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Tardon, Adonina
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Chen, Chu
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Goodman, Gary E.
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Bojesen, Stig E.
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Landi, Maria Ter ...
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Johansson, Matti ...
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Risch, Angela
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Wichmann, Heunz- ...
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Bickeboller, Hei ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne ...
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Brennan, Paul
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Field, John K.
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Shete, Sanjay
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Le Marchand, Loi ...
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Melander, Olle
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Brunnstrom, Hans
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Liu, Geoffrey
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Hung, Rayjean J.
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Caporaso, Neil E ...
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Woll, Penella J.
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Stevens, Victori ...
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Ma, Hongxia
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Jin, Guangfu
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Hu, Zhibin
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Amos, Christophe ...
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Shen, Hongbing
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University