| 1. |
- Divaris, K., et al.
(författare)
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Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium
- 2022
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Ingår i: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 101:11, s. 1408-1416
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Tidskriftsartikel (refereegranskat)abstract
- Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management avenues. Our current understanding of oral health genomics suggests that dental caries and periodontitis are polygenic diseases, and very large sample sizes and informative phenotypic measures are required to discover signals and adequately map associations across the human genome. In this article, we introduce the second wave of the Gene-Lifestyle Interactions and Dental Endpoints consortium (GLIDE2) and discuss relevant data analytics challenges, opportunities, and applications. In this phase, the consortium comprises a diverse, multiethnic sample of over 700,000 participants from 21 studies contributing clinical data on dental caries experience and periodontitis. We outline the methodological challenges of combining data from heterogeneous populations, as well as the data reduction problem in resolving detailed clinical examination records into tractable phenotypes, and describe a strategy that addresses this. Specifically, we propose a 3-tiered phenotyping approach aimed at leveraging both the large sample size in the consortium and the detailed clinical information available in some studies, wherein binary, severity-encompassing, and “precision,” data-driven clinical traits are employed. As an illustration of the use of data-driven traits across multiple cohorts, we present an application of dental caries experience data harmonization in 8 participating studies (N = 55,143) using previously developed permanent dentition tooth surface–level dental caries pattern traits. We demonstrate that these clinical patterns are transferable across multiple cohorts, have similar relative contributions within each study, and thus are prime targets for genetic interrogation in the expanded and diverse multiethnic sample of GLIDE2. We anticipate that results from GLIDE2 will decisively advance the knowledge base of mechanisms at play in oral, dental, and craniofacial health and disease and further catalyze international collaboration and data and resource sharing in genomics research.
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| 2. |
- Ivarsson, Stefan, et al.
(författare)
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Improved oscillator strengths and wavelengths for Os I and Ir I, and new results on early r-process nucleosynthesis
- 2003
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 409:3, s. 1141-1149
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Tidskriftsartikel (refereegranskat)abstract
- The radioactive decay of 238U and 232Th has recently been used to determine ages for some of the oldest stars in the Universe. This has highlighted the need for accurate observational constraints on production models for the heaviest r-process elements which might serve as stable references, notably osmium and iridium. In order to provide a firmer basis for the observed abundances, we have performed laser-induced fluorescence measurements and Fourier Transform Spectroscopy to determine new radiative lifetimes and branching fractions for selected levels in Os I and Ir I. From these data, we determine new absolute oscillator strengths and improved wavelengths for18 Os I and 4 Ir I lines. A reanalysis of VLT spectra of CS 31082-001and new results for other stars with Os and Ir detections show that (i):the lines in the UV and lambda 4260 yield reliable Os abundances, while those at lambda lambda 4135, 4420 are heavily affected by blending; (ii): the Os and Ir abundances are identical in all the stars; (iii): the heavy-element abundances in very metal-poor stars conform closely to the scaled solar r-process pattern throughout the range 56 <= Z <= 77; and (iv): neither Os or Ir nor any lighter species are suitable as reference elements for the radioactive decay of Th and U.Based in part on observations obtained with the Very Large Telescope of the European Southern Observatory at Paranal, Chile.
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| 3. |
- Sikstrom, C. M, et al.
(författare)
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The FERRUM project: experimental lifetimes of highly excited FeII 3d(6)4p levels and transition probabilities
- 1999
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Ingår i: Journal of Physics B: Atomic, Molecular and Optical Physics. - : IOP Publishing. - 0953-4075 .- 1361-6455. ; 32:24, s. 5687-5698
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Tidskriftsartikel (refereegranskat)abstract
- We report on measurements of radiative lifetimes in singly ionized iron of six 3d(6)4p levels between 61 512 and 64 041 cm(-1),using time resolved laser-induced fluorescence. Absolute oscillator strengths of 18 Fe II lines in the wavelength range from 2350 to 2800 Angstrom have been obtained by measuring branching fractions for the lines from two Fe II levels with a Fourier-transform spectrometer. The uncertainty in the lifetimes is between 8% and 13%, whereas the uncertainty of the f-values varies between 9% and 19%. A comparison with several previously published values is given.
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| 4. |
- Jinno, Yohei, et al.
(författare)
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Impact of surface contamination of implants with saliva during placement in augmented bone defects in sheep calvaria.
- 2019
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Ingår i: British Journal of Oral & Maxillofacial Surgery. - : Elsevier. - 0266-4356 .- 1532-1940. ; 57:1, s. 41-46
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Tidskriftsartikel (refereegranskat)abstract
- Our aim was to try and find out whether contamination with saliva during insertion of dental implants affects osseointegration in bone that has been augmented with different grafts. Six bony defects were created in each of the calvaria of six sheep, and then augmented with three different materials (autogenous bone, bovine bone, and resorbable biphasic ceramic bone substitute) After five weeks of healing, three implants contaminated with saliva (contaminated group) and three not contaminated (uncontaminated group) were placed in the centre of the augmented areas. For histomorphometric analysis, bone implant contact, bone area fraction occupancy, bone and material area, and bony area were measured after a healing period of five weeks. There was a significant difference between the contaminated and uncontaminated groups (p=0.036) for bone implant contact only in the augmented areas, but there were no significant differences in bone area fraction occupancy, bone and material area, and bony area. We conclude that contamination with saliva during placement of dental implants can significantly compromise bone implant contact in augmented areas, but had no significant effect on the formation of bone in areas more distant from the surface of the implant. We suggest that salivary contamination should be avoided during placement of dental implants in augmented areas.
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| 5. |
- Johansson, Krister, et al.
(författare)
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Estimation of Blood Loss in Oral and Maxillofacial Surgery by Measurements of Low Haemoglobin Levels in Mixtures of Blood, Saliva and Saline : a Laboratory Study
- 2021
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Ingår i: Journal of Oral & Maxillofacial Research. - : Stilus Optimus. - 2029-283X .- 2029-283X. ; 12:2
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Estimating blood loss is an important factor in several surgical procedures. The accuracy of blood loss measurements in situations where blood is mixed with saliva and saline is however uncertain. The purpose of this laboratory study was to ascertain if blood loss measurements in mixtures of blood, saline, and saliva are reliable and could be applicable in a clinical setting.Material and Methods: Venous blood and resting saliva were collected from six volunteers. Saliva, saline, and combinations thereof were mixed with blood to obtain different concentrations. A portable spectrophotometer was first used to measure the haemoglobin concentration in undiluted venous blood followed by measurements of the haemoglobin concentration after each dilution. To examine the strength of linear relationships, linear regression and Pearson correlations were used.Results: The measurements of haemoglobin concentrations in mixtures of blood, saline, and saliva were proven to be accurate for haemoglobin measurements > 0.3 g/dl (correlation = 0.986 to 1). For haemoglobin measurements < 0.3 g/dl, a small increase in haemoglobin values were reported, which was directly associated to the saliva concentration in the solution (correlation = 0.983 to 1). This interference of saliva was significantly eliminated by diluting the samples with saline, mimicking the clinical situation.Conclusions: The results suggest that a portable spectrophotometer can be used clinically to preoperatively measure the haemoglobin value of a venous blood sample and postoperatively measure the haemoglobin value of the collected liquids, including shed blood, thereby achieving a highly accurate method of measuring blood loss during oral and maxillofacial surgery.
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| 6. |
- Johansson, Sveneric, et al.
(författare)
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The FERRUM Project: New f-value Data for Fe II and Astrophysical Applications
- 2002
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Ingår i: Physica Scripta. - : Institute of Physics Publishing (IOPP). - 0281-1847 .- 0031-8949 .- 1402-4896. ; T100, s. 71-80
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Konferensbidrag (refereegranskat)abstract
- We present the FERRUM Project, an international collaboration aiming at a production and evaluation of oscillator strengths (transition probabilities) of selected spectral lines of singly ionized iron group elements, that are of astrophysical relevance. The results obtained include measurements and calculations of permitted and forbidden lines of Fe II. The data have been applied to both emission and absorption lines in astrophysical spectra. We make comparisons between experimental, theoretical and astrophysical f-values. We give a general review of the various measurements, and discuss the UV8 multiplet of Fe II around 1610 Šin detail.
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| 7. |
- Ketelhuth, D. F., et al.
(författare)
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Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses
- 2011
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Ingår i: Circulation. - Stockholm : Karolinska Institutet, Dept of Medicine, Solna. - 1524-4539 .- 0009-7322. ; 124:22
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Subendothelial deposited low-density lipoprotein particles are a known inflammatory factor in atherosclerosis. However, the causal components derived from low-density lipoprotein are still poorly defined. Apolipoprotein B100 (ApoB100) is the unexchangeable protein component of low-density lipoprotein, and the progression of atherosclerosis is associated with immune responses to ApoB100-derived peptides. In this study, we analyzed the proinflammatory activity of ApoB100 peptides in atherosclerosis. METHODS AND RESULTS: By screening a peptide library of ApoB100, we identified a distinct native peptide referred to as ApoB100 danger-associated signal 1 (ApoBDS-1), which shows sequence-specific bioactivity in stimulation of interleukin-8, CCL2, and interleukin-6. ApoBDS-1 activates mitogen-activated protein kinase and calcium signaling, thereby effecting the expression of interleukin-8 in innate immune cells. Ex vivo stimulation of carotid plaques with ApoBDS-1 enhances interleukin-8 and prostaglandin E release. Furthermore, we demonstrated that ApoBDS-1-positive peptide fragments are present in atherosclerotic lesions using immunoassays and that low-molecular-weight fractions isolated from plaque show ApoBDS-1 activity inducing interleukin-8 production. CONCLUSIONS: Our data show that ApoBDS-1 is a previously unrecognized peptide with robust proinflammatory activity, contributing to the disease-promoting effects of low-density lipoprotein in the pathogenesis of atherosclerosis.
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| 8. |
- Martell, J., et al.
(författare)
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Combined Neutron and X-Ray Tomography-A Versatile and Non-Destructive Tool in Planetary Geosciences
- 2024
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Ingår i: Journal of Geophysical Research - Planets. - : American Geophysical Union (AGU). - 2169-9097 .- 2169-9100. ; 129:2
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Forskningsöversikt (refereegranskat)abstract
- With several upcoming sample return missions, such as the Mars Sample Return Campaign, non-destructive methods will be key to maximizing their scientific output. In this study, we demonstrate that the combination of neutron and X-ray tomography provides an important tool for the characterization of such valuable samples. These methods allow quantitative analyses of internal sample features and also provide a guide for further destructive analyses with little to no sample treatment, which maintains sample integrity, including minimizing the risk of potential contamination. Here, we present and review the results from four case studies of terrestrial impactites and meteorites along with their analytical setup. Using combined X-ray and neutron tomography, a Ni-Fe silicide spherule, that is, projectile material, was located within a Libyan Desert Glass sample and the distribution of hydrous phases was pinpointed in selected impactite samples from the Chicxulub IODP-ICDP Expedition 364 drill core and the Luizi impact structure, as well as in the Miller Range 03346 Martian meteorite. Neutron and X-ray tomography give complementary three-dimensional information about the distribution of different phases within a geologic sample. We demonstrate that these two methods can be successfully used to locate meteoritic material (i.e., from the impacting object) and hydrous components in terrestrial impactites and meteorites. This can help shed light on aqueous processes in the Solar System as well as the impact cratering process. Non-destructive methods like these will be important for up-coming sample return missions to characterize the returned samples and guide further destructive analyses. Combined neutron and X-ray imaging was used to locate projectile material and hydrous phases in meteorites and terrestrial impactites Locating and identifying projectile material can shed light on the impact cratering process Combined neutron/X-ray tomography can serve as a fundamental method for the characterization of material from (future) sample return missions
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| 9. |
- Pickering, J. C., et al.
(författare)
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The FERRUM Project: Experimental oscillator strengths of the UV 8 multiplet and other UV transitions from the y6P levels of Fe II
- 2002
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Ingår i: Astronomy & Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 396:2, s. 715-722
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Tidskriftsartikel (refereegranskat)abstract
- We report on experimental branching fractions (BFs) for 19 transitions from the three 3d 5( 6S)4s4p( 3P) y6P levels in Fe II, measured in Fourier transform spectra of a Penning discharge lamp and a hollow cathode lamp. The transition wavelengths span the interval between 1600 and 2850 Å. Absolute oscillator strengths ( f-values) have been derived by combining the BFs with experimental radiative lifetimes recently reported in the literature. Theoretical f-values have been calculated using configuration interaction wavefunctions. The new experimental and theoretical f-values are compared with data available in the literature and in databases. The strongest lines measured belong to the UV 8 multiplet of Fe II, which has one ground state transition appearing as a prominent feature at 1608 Å in interstellar spectra. The line is accompanied by a satellite at 1611 Å due to a level mixing, which is discussed in the paper.
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