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- Campbell, PJ, et al.
(författare)
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Pan-cancer analysis of whole genomes
- 2020
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
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Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
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| 8. |
- Abdallah, J, et al.
(författare)
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Charged particle multiplicity in three-jet events and two-gluon systems
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; C:44, s. 311-331
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Tidskriftsartikel (refereegranskat)abstract
- The charged particle multiplicity in hadronic three-jet events from Z decays is investigated. The topology dependence of the event multiplicity is found to be well described by a modified leading logarithmic prediction. A parameter fit of the prediction to the data yields a measurement of the colour factor ratio C-A/C-F with the result C-A/C-F = 2.261 +/- 0.014(stat). +/- 0.036(exp). +/- 0-066(theo). in agreement with the SU(3) expectation of QCD. The quark-related contribution to the event multiplicity is subtracted from the three-jet event multiplicity resulting in a measurement of the multiplicity of two-gluon colour-singlet states over a wide energy range. The ratios r = N-gg(s)/Ng (g) over bar (s) of the gluon and quark multiplicities and r((1)) = N'(gg)(s)/N'g (g) over bar (s) of their derivatives are compared with perturbative calculations. While a good agreement between calculations and data is observed for r((1)), larger deviations are found for r indicating that non-perturbative effects are more important for r than for r((1)).
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| 9. |
- Abdallah, J, et al.
(författare)
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Production of Xi(0)(c) and Xi(b) in Z decays and lifetime measurement of Xi(b)
- 2005
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Ingår i: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; C:44, s. 299-309
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Tidskriftsartikel (refereegranskat)abstract
- The charmed strange baryon Xi(c)(0) was searched for in the decay channel Xi(c)(0) -> Xi(-)pi(+), and the beauty strange baryon Xi(b) in the inclusive channel Xi(b) -> Xi(-)l(-)(nu) over barX, using the 3.5 million hadronic Z events collected by the DELPHI experiment in the years 1992-1995. The Xi(-) was reconstructed through the decay AT, using a constrained fit method for cascade decays. An iterative discriminant analysis was used for the Xi(c)(0) and Xi(b) selection. The production rates were measured to be f(Xi c)(0) x BR(Xi(c)(0) -> Xi(-)pi(+) = (4.7 +/- 1.4(stat.) +/- 1.1(syst.)) x 10(-4) per hadronic Z decay, and BR(b -> Xi(b))xBR(Xi(b) -> Xi(-)l(-)X) = (3.0 +/- 1.0(stat.) +/- 0.3(syst.)) x 10(-4) for each lepton species (electron or muon). The lifetime of the Xi(b) baryon was measured to be tau(Xi b) = 1.45(-0.43)(+0.55)(stat.)+/- 0.13(syst.) ps. A combination with the previous DELPHI lifetime measurement gives tau(Xi b) = 1.48(-0.31)(+0.40)(stat.)+/- 0.12(syst.) ps.
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| 10. |
- Johansson, JE, et al.
(författare)
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Fifteen-year survival in prostate cancer - A prospective, population-based study in Sweden
- 1997
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Ingår i: JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. - : AMER MEDICAL ASSOC. - 0098-7484. ; 277:6, s. 467-471
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Tidskriftsartikel (refereegranskat)abstract
- Objective.-To describe the natural history of initially untreated early-stage prostate cancer. A key secondary objective was to calculate long-term survival rates by stage, grade, and age at diagnosis. Design.-Prospective cohort study, Setting.-Population
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