| 1. |
- Campbell, PJ, et al.
(författare)
-
Pan-cancer analysis of whole genomes
- 2020
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 578:7793, s. 82-
-
Tidskriftsartikel (refereegranskat)abstract
- Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Huang, TS, et al.
(författare)
-
A cell adhesion protein from the crayfish Pacifastacus leniusculus, a serine proteinase homologue similar to Drosophila masquerade
- 2000
-
Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 275:14, s. 9996-10001
-
Tidskriftsartikel (refereegranskat)abstract
- A cDNA encoding a protein resembling masquerade, a serine proteinase homologue expressed during embryogenesis, larval, and pupal development in Drosophila melanogaster, was identified in hemocytes of the adult freshwater crayfish, Pacifastacus leniusculus. The crayfish protein is similar to Drosophila masquerade in the following aspects: (a) overall sequence of the serine proteinase domain, such as the position of three putative disulfide bridges, glycine in the place of the catalytic serine residue, and the presence of a substrate-lining pocket typical for trypsins; (b) the presence of several copies of a disulfide-knotted motif in the putative propeptide. This masquerade-like protein is cleaved into a 27-kDa fragment, which could be detected by immunoblot analysis using an affinity-purified antibody against a synthetic peptide in the C-terminal domain of the protein. The 27-kDa protein could be immunoaffinity-purified from hemocyte lysate supernatant and exhibited cell adhesion activity in vitro, indicating that the C-terminal domain of the crayfish masquerade-like protein mediates cell adhesion.
|
|
| 5. |
|
|
| 6. |
- Johansson, MW
(författare)
-
Cell adhesion molecules in invertebrate immunity
- 1999
-
Ingår i: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0145-305X. ; 23:4-5, s. 303-315
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Cell adhesion is essential in immunity in invertebrates, e.g., in the cellular immune responses of encapsulation and nodule formation. Here cell adhesion molecules shown or suggested to be involved in invertebrate immunity are reviewed. Blood cells of the
|
|
| 7. |
- Johansson, MW, et al.
(författare)
-
Crustacean haemocytes and haematopoiesis
- 2000
-
Ingår i: AQUACULTURE. - 0044-8486. ; 191:1-3, s. 45-52
-
Tidskriftsartikel (refereegranskat)abstract
- Crustacean haemocytes play important roles in the host immune response including recognition, phagocytosis, melanization, cytotoxicity and cell-cell communication. Classification of the haemocyte types in decapod crustaceans is based mainly on the presenc
|
|
| 8. |
- JOHANSSON, MW, et al.
(författare)
-
PEROXINECTIN, A NOVEL CELL-ADHESION PROTEIN FROM CRAYFISH BLOOD
- 1995
-
Ingår i: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - : ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS. - 0006-291X. ; 216:3, s. 1079-1087
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- From blood cells of the crayfish Pacifastacus leniusculus a 76-kDa protein that mediated attachment and spreading of the crayfish blood cells was purified. The cDNA for this cell adhesion protein was isolated, cloned, and sequenced. The deduced protein se
|
|
| 9. |
|
|
| 10. |
|
|
