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| 2. |
- Johansson, Per, et al.
(författare)
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Convergence of chromogranin and amyloid metabolism in the brain.
- 2010
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5279 .- 1552-5260. ; 6:4, s. 511-511
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Konferensbidrag (refereegranskat)abstract
- Background: Much is unknown regarding the regulation of amyloid precursor protein (APP) processing in the human central nervous system. It has been hypothesized that amyloidogenic APP-processing preferentially occurs in the regulated secretory pathway of neurons. To test this hypothesis we looked for correlations of APP-derived molecules in CSF with chromogranin (Cg) derived peptides, representing the regulated secretion. Methods: Patients with Alzheimer's disease (AD, N = 32), multiple sclerosis (MS, N = 50) and healthy controls (N = 70) were enrolled. CSF was analyzed for the amyloid peptides Aβ1-42, Aβx-42, Aβx-40, Aβx-38, α-cleaved soluble APP (α-sAPP), β-cleaved soluble APP (β-sAPP), and peptides derived from CgB and SgII (Secretogranin-II, CgC). We investigated CSF levels of the protease BACE1, which processes APP into Aβ, in relation to Cg-levels. Finally, we measured Cg levels in cell media from untreated and BACE1-inhibited SH-SY5Y human neuroblastoma cells. Results: CSF Cg levels correlated to sAPP and Aβ peptides in AD, MS and controls, and to CSF BACE1. Cell medium from BACE1-inhibited cells had decreased CgB levels. Conclusions: These results suggest that a large part of APP in the human central nervous system is processed in the regulated secretory pathway of neurons.
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| 4. |
- Algaba-Brazalez, A., et al.
(författare)
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Compact Polarization Transformation in a Geodesic Luneburg Lens Antenna
- 2021
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Ingår i: 2021 IEEE International Symposium on Antennas and Propagation and North American Radio Science Meeting, APS/URSI 2021 - Proceedings. - : Institute of Electrical and Electronics Engineers Inc.. ; , s. 1992-1993
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Konferensbidrag (refereegranskat)abstract
- This paper describes the design of a compact polarizer that rotates the linear polarization of a fully metallic geodesic Luneburg lens antenna for applications requiring polarization diversity. The polarization rotation is achieved by loading the radiating aperture of the antenna with two metallic screens. The integrated antenna operates in the Ka-band, from 25 to 31 GHz, showing around 20% bandwidth with S11 below -10 dB, and a scanning range of 100°.
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| 5. |
- Algaba-Brazalez, Astrid, et al.
(författare)
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Crossover level improvement between beams in a geodesic lens antenna based on a generalized Luneburg lens
- 2022
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Ingår i: 2022 16th European Conference on Antennas and Propagation (EuCAP). - : Institute of Electrical and Electronics Engineers (IEEE).
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Konferensbidrag (refereegranskat)abstract
- In this paper, we propose a geodesic generalized Luneburg lens operating in the 60-GHz band, from 57 to 67 GHz, designed with the goal to improve the crossover level between beams with respect to previously reported fully metallic Luneburg lenses, while providing highly directive beams and wide scanning coverage. We have combined the use of a generalized Luneburg lens and the design of a compact feeding type based on ridge waveguide in order to achieve an optimum crossover level between beams keeping in mind manufacturing simplicity. The numerical evaluation of the final integrated lens design including 21 ridge waveguide feeding ports shows a vertical bar S-11 vertical bar parameter below -13.6 dB over the frequency band of interest, a scanning range of +/- 52 degrees, a realized gain higher than 19 dBi over the whole operating bandwidth, and a crossover level value between -3.5 dB and -4.2 dB from the lowest to the highest frequency of operation.
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| 6. |
- Andreasson, U., et al.
(författare)
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An enzyme activity as a potential biomarker for Alzheimer's disease.
- 2010
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Ingår i: Alzheimer's & Dementia. - : Wiley. - 1552-5279 .- 1552-5260. ; 6:4, s. 497-498
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Konferensbidrag (refereegranskat)abstract
- Background: Six different N-terminal amyloid precursor protein (APP) fragments, with molecular weight ∼12 kDa, have previously been identified in human cerebrospinal fluid (CSF). In a pilot study, both the sum of their concentrations, measured by western blot, and the relative abundance pattern, measured by mass spectrometry, were different in Alzheimer's disease (AD) patients compared to healthy controls. To test if these differences were also reflected in protease activities that possibly give rise to the ∼12 kDa fragments an enzymatic assay was developed and the activity in CSF was investigated for its potential as a biomarker for AD. Methods: The substrate in the protease activity assay was a custom made fluorochrome/quencher labeled peptide that covers the cleavage sites in APP (APP118-APP127) corresponding to the C-termini of the six ∼12 kDa APP fragments. The activity was measured in CSF from 55 AD patients and 17 controls. Results: There was a significant increase in the protease activity in CSF from AD patients compared to the controls (p = 0.001). This is in line with previous results which indicate that the sum of the ∼12 kDa fragments are elevated in AD. Results from inhibition studies strongly suggests that the enzyme responsible for the cleavage of the substrate is an aspartic protease since a sub nM IC50 value was recorded for Pepstatin A while no inhibition was observed for the cysteine protease specific inhibitor E64 at concentrations up to100 nM. Conclusions: There exists an enzymatic activity in CSF capable of cleaving a peptide substrate that spans a portion, close to the N-terminal, of APP. In a pilot study the activity is increased in AD patients compared to controls suggesting that it can be used as a biomarker.
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| 7. |
- Ben Henda, N., et al.
(författare)
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OpenSAW : Open security analysis workbench
- 2017
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Ingår i: 20th International Conference on Fundamental Approaches to Software Engineering, FASE 2017 Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017. - Berlin, Heidelberg : Springer Berlin/Heidelberg. - 9783662544938 ; , s. 321-337
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Konferensbidrag (refereegranskat)abstract
- Software is today often composed of many sourced componets, which potentially contain security vulnerabilities, and therefore require testing before being integrated. Tools for automated test case generation, for example, based on white-box fuzzing, are beneficial for this testing task. Such tools generally explore limitations of the specific underlying techniques for solving problems related to, for example, constraint solving, symbolic execution, search heuristics and execution trace extraction. In this article we describe the design of OpenSAW, a more flexible general-purpose white-box fuzzing framework intended to encourage research on new techniques identifying security problems. In addition, we have formalized two unaddressed technical aspects and devised new algorithms for these. The first relates to generalizing and combining different program exploration strategies, and the second relates to prioritizing execution traces. We have evaluated OpenSAW using both in-house and external programs and identified several bugs.
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| 8. |
- Ben Henda, Noomene, et al.
(författare)
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OpenSAW: Open Security Analysis Workbench
- 2017. - 1
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Ingår i: Fundamental Approaches to Software Engineering : 20th International Conference, FASE 2017, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017, Uppsala, Sweden, April 22-29, 2017, Proceedings - 20th International Conference, FASE 2017, Held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2017, Uppsala, Sweden, April 22-29, 2017, Proceedings. - Berlin, Heidelberg : Springer Berlin Heidelberg. - 9783662544938 - 9783662544945 ; 10202, s. 321-337
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Konferensbidrag (refereegranskat)abstract
- Software is today often composed of many sourced components, which potentially contain security vulnerabilities, and therefore require testing before being integrated. Tools for automated test case generation, for example, based on white-box fuzzing, are beneficial for this testing task. Such tools generally explore limitations of the specific underlying techniques for solving problems related to, for example, constraint solving, symbolic execution, search heuristics and execution trace extraction. In this article we describe the design of OpenSAW, a more flexible general-purpose white-box fuzzing framework intended to encourage research on new techniques identifying security problems. In addition, we have formalized two unaddressed technical aspects and devised new algorithms for these. The first relates to generalizing and combining different program exploration strategies, and the second relates to prioritizing execution traces. We have evaluated OpenSAW using both in-house and external programs and identified several bugs.
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| 9. |
- Bengtsson, Kristofer, 1979, et al.
(författare)
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Emergency department overview - Improving the dynamic capabilities using an event-driven information architecture
- 2016
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Ingår i: IEEE International Conference on Emerging technologies and factory automation (ETFA) 2016.
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Konferensbidrag (refereegranskat)abstract
- It is challenging to get an overview and understand- ing of what is going on at an emergency department (ED). This is due to the sometimes turbulent work environment and a large variation in patient processes. To increase the dynamic capability and responsiveness of an ED, it is important that the staff and patients have an overview of what is going on and what will happen in the coming hours. This paper presents a smart online support software that shows the current state of the ED as well as a prediction of the coming hours. The software has been developed as a case study of using agile development ideas when developing new systems for hospitals. The result shows that the use of the event-driven information architecture for healthcare (EVAH) enabled a rapid development of a successful running application, helping the nurses getting an overview of current situation and the coming hours.
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| 10. |
- Castillo Tapia, Pilar, et al.
(författare)
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Azimuth and Elevation Scanning with Stacked Modulated Geodesic Luneburg Lenses
- 2022
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Ingår i: 2022 INTERNATIONAL SYMPOSIUM ON ANTENNAS AND PROPAGATION (ISAP). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 5-6
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Konferensbidrag (refereegranskat)abstract
- Here, we propose a modulated geodesic lens antenna array in E-band (56-62 GHz), which has scanning abilities in both azimuth and elevation. The array consists of four lens antenna elements, and each lens antenna produces 13 independent beams that cover 110 degrees in the H-plane with scan losses below 1 dB. The array is fed with a 1:4 power divider comprising three phase shifters to scan in the E-plane. The distance between lenses in the E-plane is 0.7 wavelengths at 60 GHz. The E-plane coverage is 60 degrees with scan losses around -2.2 dB. The maximum realized gain varies from 20.8 to 24.1 dB across the frequency band.
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