Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

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Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

Zahed, Hana (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization

Johansson, Mattias (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization

Ueland, Per M. (author): Department of Clinical Science, University of Bergen, Bergen, Norway

Midttun, Øivind (author): Bevital AS, Bergen, Norway

Milne, Roger L. (author): Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

Giles, Graham G. (author): Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

Manjer, Jonas (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital

Sandsveden, Malte (author): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups

Langhammer, Arnulf (author): Department of Public Health and Nursing, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway

Sørgjerd, Elin Pettersen (author): Department of Public Health and Nursing, NTNU, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Levanger, Norway

Grankvist, Kjell (author): Umeå University,Umeå universitet,Klinisk kemi

Johansson, Mikael (author): Umeå University,Umeå universitet,Onkologi,Harvard University,Brigham and Women's Hospital / Harvard Medical School

Freedman, Neal D. (author): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI

Huang, Wen-Yi (author): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI

Chen, Chu (author): Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States

Prentice, Ross (author): Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States

Stevens, Victoria L. (author): American Cancer Society, Atlanta, United States

Wang, Ying (author): American Cancer Society, Atlanta, United States

Le Marchand, Loic (author): University of Hawai’i Cancer Center, University of Hawaiʻi at Mānoa, Honolulu, United States

Wilkens, Lynne R. (author): University of Hawai’i Cancer Center, University of Hawaiʻi at Mānoa, Honolulu, United States

Weinstein, Stephanie J. (author): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI

Albanes, Demetrius (author): Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI

Cai, Qiuyin (author): Vanderbilt University Medical Center, Nashville, United States

Blot, William J. (author): Vanderbilt University Medical Center, Nashville, United States

Arslan, Alan A. (author): Department of Obstetrics and Gynecology, NYU Langone Health, NY, New York, United States; Department of Population Health, NYU Langone Health, NY, New York, United States; Perlmutter Comprehensive Cancer Center, NYU Langone Health, NY, New York, United States,International Agency for Research on Cancer, World Health Organization

Zeleniuch-Jacquotte, Anne (author): Department of Population Health, NYU Langone Health, NY, New York, United States; Perlmutter Comprehensive Cancer Center, NYU Langone Health, NY, New York, United States

Shu, Xiao-Ou (author): Vanderbilt University Medical Center, Nashville, United States

Zheng, Wei (author): Vanderbilt University Medical Center, Nashville, United States

Yuan, Jian-Min (author): University of Pittsburgh Medical Center, Pittsburgh, United States

Koh, Woon-Puay (author): Duke - NUS Medical School, Singapore, Singapore

Visvanathan, Kala (author): Johns Hopkins Institute for Clinical and Translational Research, Baltimore, United States,Johns Hopkins University

Sesso, Howard D. (author): Brigham and Women’s Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University

Zhang, Xuehong (author): Brigham and Women’s Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University

Gaziano, J. Michael (author): Harvard T.H. Chan School of Public Health, Boston, United States; Brigham and Women’s Hospital, Boston, United States

Fanidi, Anouar (author): Université Claude Bernard Lyon 1, Lyon, France

Muller, David (author): Imperial College London School of Public Health, London, United Kingdom

Brennan, Paul (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization

Guida, Florence (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization

Robbins, Hilary A. (author): Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France

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2021-07-05
2021
English.
In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://www.nature.c...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

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