Sökning: WFRF:(Johansson Roger)
> (2020-2021)
> Weinstein Stephanie J >
Epidemiology of 40 ...
Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults
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- Zahed, Hana (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Ueland, Per M. (författare)
- Department of Clinical Science, University of Bergen, Bergen, Norway
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visa fler...
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- Midttun, Øivind (författare)
- Bevital AS, Bergen, Norway
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- Milne, Roger L. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
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- Giles, Graham G. (författare)
- Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia
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- Manjer, Jonas (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Sandsveden, Malte (författare)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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- Langhammer, Arnulf (författare)
- Department of Public Health and Nursing, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
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- Sørgjerd, Elin Pettersen (författare)
- Department of Public Health and Nursing, NTNU, Hunt Research Centre, Norwegian University of Science and Technology, Levanger, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim University Hospital, Levanger, Norway
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- Grankvist, Kjell (författare)
- Umeå University,Umeå universitet,Klinisk kemi
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- Johansson, Mikael (författare)
- Umeå University,Umeå universitet,Onkologi,Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Freedman, Neal D. (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Huang, Wen-Yi (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Chen, Chu (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States
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- Prentice, Ross (författare)
- Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, United States
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- Stevens, Victoria L. (författare)
- American Cancer Society, Atlanta, United States
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- Wang, Ying (författare)
- American Cancer Society, Atlanta, United States
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- Le Marchand, Loic (författare)
- University of Hawai’i Cancer Center, University of Hawaiʻi at Mānoa, Honolulu, United States
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- Wilkens, Lynne R. (författare)
- University of Hawai’i Cancer Center, University of Hawaiʻi at Mānoa, Honolulu, United States
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- Weinstein, Stephanie J. (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Albanes, Demetrius (författare)
- Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States,National Cancer Institute, NCI
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- Cai, Qiuyin (författare)
- Vanderbilt University Medical Center, Nashville, United States
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- Blot, William J. (författare)
- Vanderbilt University Medical Center, Nashville, United States
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- Arslan, Alan A. (författare)
- Department of Obstetrics and Gynecology, NYU Langone Health, NY, New York, United States; Department of Population Health, NYU Langone Health, NY, New York, United States; Perlmutter Comprehensive Cancer Center, NYU Langone Health, NY, New York, United States,International Agency for Research on Cancer, World Health Organization
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- Zeleniuch-Jacquotte, Anne (författare)
- Department of Population Health, NYU Langone Health, NY, New York, United States; Perlmutter Comprehensive Cancer Center, NYU Langone Health, NY, New York, United States
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- Shu, Xiao-Ou (författare)
- Vanderbilt University Medical Center, Nashville, United States
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- Zheng, Wei (författare)
- Vanderbilt University Medical Center, Nashville, United States
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- Yuan, Jian-Min (författare)
- University of Pittsburgh Medical Center, Pittsburgh, United States
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- Koh, Woon-Puay (författare)
- Duke - NUS Medical School, Singapore, Singapore
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- Visvanathan, Kala (författare)
- Johns Hopkins Institute for Clinical and Translational Research, Baltimore, United States,Johns Hopkins University
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- Sesso, Howard D. (författare)
- Brigham and Women’s Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University
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- Zhang, Xuehong (författare)
- Brigham and Women’s Hospital, Harvard Medical School, Boston, United States; Harvard T.H. Chan School of Public Health, Boston, United States,Harvard University
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- Gaziano, J. Michael (författare)
- Harvard T.H. Chan School of Public Health, Boston, United States; Brigham and Women’s Hospital, Boston, United States
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- Fanidi, Anouar (författare)
- Université Claude Bernard Lyon 1, Lyon, France
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- Muller, David (författare)
- Imperial College London School of Public Health, London, United Kingdom
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- Brennan, Paul (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Guida, Florence (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France,International Agency for Research on Cancer, World Health Organization
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- Robbins, Hilary A. (författare)
- Genomic Epidemiology Branch, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
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(creator_code:org_t)
- 2021-07-05
- 2021
- Engelska.
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Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 11:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://www.nature.c...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Imbalances of blood biomarkers are associated with disease, and biomarkers may also vary non-pathologically across population groups. We described variation in concentrations of biomarkers of one-carbon metabolism, vitamin status, inflammation including tryptophan metabolism, and endothelial and renal function among cancer-free older adults. We analyzed 5167 cancer-free controls aged 40–80 years from 20 cohorts in the Lung Cancer Cohort Consortium (LC3). Centralized biochemical analyses of 40 biomarkers in plasma or serum were performed. We fit multivariable linear mixed effects models to quantify variation in standardized biomarker log-concentrations across four factors: age, sex, smoking status, and body mass index (BMI). Differences in most biomarkers across most factors were small, with 93% (186/200) of analyses showing an estimated difference lower than 0.25 standard-deviations, although most were statistically significant due to large sample size. The largest difference was for creatinine by sex, which was − 0.91 standard-deviations lower in women than men (95%CI − 0.98; − 0.84). The largest difference by age was for total cysteine (0.40 standard-deviation increase per 10-year increase, 95%CI 0.36; 0.43), and by BMI was for C-reactive protein (0.38 standard-deviation increase per 5-kg/m2 increase, 95%CI 0.34; 0.41). For 31 of 40 markers, the mean difference between current and never smokers was larger than between former and never smokers. A statistically significant (p < 0.05) association with time since smoking cessation was observed for 8 markers, including C-reactive protein, kynurenine, choline, and total homocysteine. We conclude that most blood biomarkers show small variations across demographic characteristics. Patterns by smoking status point to normalization of multiple physiological processes after smoking cessation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Zahed, Hana
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Johansson, Matti ...
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Ueland, Per M.
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Midttun, Øivind
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Milne, Roger L.
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Giles, Graham G.
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visa fler...
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Manjer, Jonas
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Sandsveden, Malt ...
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Langhammer, Arnu ...
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Sørgjerd, Elin P ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Freedman, Neal D ...
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Huang, Wen-Yi
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Chen, Chu
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Prentice, Ross
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Stevens, Victori ...
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Wang, Ying
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Le Marchand, Loi ...
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Wilkens, Lynne R ...
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Weinstein, Steph ...
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Albanes, Demetri ...
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Cai, Qiuyin
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Blot, William J.
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Arslan, Alan A.
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Zeleniuch-Jacquo ...
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Shu, Xiao-Ou
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Zheng, Wei
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Yuan, Jian-Min
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Koh, Woon-Puay
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Visvanathan, Kal ...
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Sesso, Howard D.
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Zhang, Xuehong
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Gaziano, J. Mich ...
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Fanidi, Anouar
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Muller, David
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Brennan, Paul
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Guida, Florence
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Robbins, Hilary ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Umeå universitet
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Lunds universitet