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- Franceschini, N., et al.
(author)
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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
- 2018
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1
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Journal article (peer-reviewed)abstract
- Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans. © 2018, The Author(s).
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| 4. |
- Voight, Benjamin F, et al.
(author)
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Plasma HDL cholesterol and risk of myocardial infarction : a mendelian randomisation study
- 2012
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 380:9841, s. 572-580
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Journal article (peer-reviewed)abstract
- BACKGROUND: High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease is causal.METHODS: We performed two mendelian randomisation analyses. First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls). Second, we used as an instrument a genetic score consisting of 14 common SNPs that exclusively associate with HDL cholesterol and tested this score in up to 12,482 cases of myocardial infarction and 41,331 controls. As a positive control, we also tested a genetic score of 13 common SNPs exclusively associated with LDL cholesterol.FINDINGS: Carriers of the LIPG 396Ser allele (2·6% frequency) had higher HDL cholesterol (0·14 mmol/L higher, p=8×10(-13)) but similar levels of other lipid and non-lipid risk factors for myocardial infarction compared with non-carriers. This difference in HDL cholesterol is expected to decrease risk of myocardial infarction by 13% (odds ratio [OR] 0·87, 95% CI 0·84-0·91). However, we noted that the 396Ser allele was not associated with risk of myocardial infarction (OR 0·99, 95% CI 0·88-1·11, p=0·85). From observational epidemiology, an increase of 1 SD in HDL cholesterol was associated with reduced risk of myocardial infarction (OR 0·62, 95% CI 0·58-0·66). However, a 1 SD increase in HDL cholesterol due to genetic score was not associated with risk of myocardial infarction (OR 0·93, 95% CI 0·68-1·26, p=0·63). For LDL cholesterol, the estimate from observational epidemiology (a 1 SD increase in LDL cholesterol associated with OR 1·54, 95% CI 1·45-1·63) was concordant with that from genetic score (OR 2·13, 95% CI 1·69-2·69, p=2×10(-10)).INTERPRETATION: Some genetic mechanisms that raise plasma HDL cholesterol do not seem to lower risk of myocardial infarction. These data challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
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- 2019
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Journal article (peer-reviewed)
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| 6. |
- Akkoyun, S., et al.
(author)
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AGATA - Advanced GAmma Tracking Array
- 2012
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In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. - : Elsevier BV. - 0168-9002 .- 0167-5087 .- 1872-9576. ; 668, s. 26-58
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Journal article (peer-reviewed)abstract
- The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation γ-ray spectrometer. AGATA is based on the technique of γ-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a γ ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of γ-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector- response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. © 2011 Elsevier B.V. All rights reserved.
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| 7. |
- Andgren, Karin, et al.
(author)
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Excited states in the neutron-deficient nuclei Rn-197,Rn-199,Rn-201
- 2008
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 77:5, s. 054303-1-054303-7
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Journal article (peer-reviewed)abstract
- Excited states of the extremely neutron-deficient radon isotopes with N = 111, 113, 115 have been studied for the first time in a series of in-beam experiments performed at the Accelerator Laboratory of the University of Jyvaskyla. The reactions used were: Sn-118(Kr-82, 3n)Rn-197, Sn-120(Kr-82, 3n)Rn-199, Sm-150(Cr-52, 3n)Rn-199, and Sn-122(Kr-82, 3n)Rn-201. The gamma rays emitted from excited states in the different isotopes were identified using the recoil-alpha-decay tagging technique. The estimated cross section for the production of Rn-197(m) was 7(3) nb, which is the lowest cross section reported so far for an in-beam study. The energies of the (17/2(+)) levels built on the isomeric (13/2(+)) states in Rn-197,Rn-199,Rn-201 indicate a transition from an anharmonic vibrational structure toward a rotational structure at low spins for these nuclei. However, the transition is not as sharp as predicted by theory.
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| 8. |
- Andgren, Karin, et al.
(author)
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gamma-ray spectroscopy of At-197
- 2008
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 78:4, s. 044328-1-044328-8
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Journal article (peer-reviewed)abstract
- Excited states of the extremely neutron-deficient nucleus At-197 have been studied in an in-beam experiment using the fusion-evaporation reaction Sn-118(Kr-82,p2n)At-197. gamma rays belonging to At-197 feeding the I-pi=(9/2(-)) ground state, as well as gamma rays feeding the 311-keV I-pi=(13/2(+)) isomer, decaying via the emission of gamma rays, and the 52-keV I-pi=(1/2(+)) alpha-decaying isomer have been identified using the recoil-alpha-decay tagging technique. Total Routhian surface calculations predict a near-spherical shape for the (9/2(-)) ground state and oblate shapes with beta(2) around -0.2 for the (1/2(+)) and the (13/2(+)) states. These predictions agree with our experimental findings.
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| 9. |
- Andgren, Karin, et al.
(author)
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Low-spin collective behavior in the transitional nuclei Mo-86,Mo-88
- 2007
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 76:1, s. 014307-
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Journal article (peer-reviewed)abstract
- Low-spin structures in Mo-86,Mo-88 were populated using the Ni-58(Ar-36, x alpha yp) heavy-ion fusion-evaporation reaction at a beam energy of 111 MeV. Charged particles and gamma rays were emitted in the reactions and detected by the DIAMANT CsI ball and the EXOGAM Ge array, respectively. In addition to the previously reported low-to-medium spin states in these nuclei, new low-spin structures were observed. Angular correlation and linear polarization measurements were performed in order to unambiguously determine the spins and parities of intensely populated states in Mo-88. Quasiparticle Random Phase Approximation (QRPA) calculations were performed for the first and second excited 2(+) states in Mo-86 and Mo-88. The results are in qualitative agreement with the experimental results, supporting a collective interpretation of the low-spin states for these transitional nuclei.
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| 10. |
- Ashrafi, S., et al.
(author)
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Monte-Carlo simulation of the charged particle detector used in the NORDBALL gamma-ray spectrometer
- 2001
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In: Nuclear Instruments and Methods in Physics Research Section A. - 0168-9002 .- 1872-9576. ; 458:3, s. 690-697
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Journal article (peer-reviewed)abstract
- The NORDBALL silicon detector array for detecting light charged particles emitted in fusion evaporation reactions was simulated with the Monte-Carlo method. The data from the reaction of 261 MeV Ni-58 ions with Cr-50 nuclei in a 4.8 mg/cm(2) thick target was used to adjust the simulation parameters. Relative population of residual nuclei in the reaction was determined, by comparing the intensities of gamma -rays.
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