SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Jones Michael) ;lar1:(ri)"

Sökning: WFRF:(Jones Michael) > RISE

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Bennion, Douglas M, et al. (författare)
  • Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke : a nose-to-brain delivery approach.
  • 2018
  • Ingår i: Clinical Science. - 0143-5221 .- 1470-8736. ; 132:5, s. 581-593
  • Tidskriftsartikel (refereegranskat)abstract
    • Significant neuroprotective effects of angiotensin II type 2 (AT2) receptor (AT2 receptor) agonists in ischemic stroke have been previously demonstrated in multiple studies. However, the routes of agonist application used in these pre-clinical studies, direct intracerebroventricular (ICV) and systemic administration, are unsuitable for translation into humans; in the latter case because AT2 receptor agonists are blood-brain barrier (BBB) impermeable. To circumvent this problem, in the current study we utilized the nose-to-brain (N2B) route of administration to bypass the BBB and deliver the selective AT2 receptor agonist Compound 21 (C21) to naïve rats or rats that had undergone endothelin 1 (ET-1)-induced ischemic stroke. The results obtained from the present study indicated that C21 applied N2B entered the cerebral cortex and striatum within 30 min in amounts that are therapeutically relevant (8.4-9 nM), regardless of whether BBB was intact or disintegrated. C21 was first applied N2B at 1.5 h after stroke indeed provided neuroprotection, as evidenced by a highly significant, 57% reduction in cerebral infarct size and significant improvements in Bederson and Garcia neurological scores. N2B-administered C21 did not affect blood pressure or heart rate. Thus, these data provide proof-of-principle for the idea that N2B application of an AT2 receptor agonist can exert neuroprotective actions when administered following ischemic stroke. Since N2B delivery of other agents has been shown to be effective in certain human central nervous system diseases, the N2B application of AT2 receptor agonists may become a viable mode of delivering these neuroprotective agents for human ischemic stroke patients
  •  
2.
  • Recchia, Gabriel, et al. (författare)
  • Encoding Sequential Information in Vector Space Models of Semantics: Comparing Holographic Reduced Representation and Random Permutation
  • 2010. - 11
  • Konferensbidrag (refereegranskat)abstract
    • Encoding information about the order in which words typically appear has been shown to improve the performance of high-dimensional semantic space models. This requires an encoding operation capable of binding together vectors in an order-sensitive way, and efficient enough to scale to large text corpora. Although both circular convolution and random permutations have been enlisted for this purpose in semantic models, these operations have never been systematically compared. In Experiment 1 we compare their storage capacity and probability of correct retrieval; in Experiments 2 and 3 we compare their performance on semantic tasks when integrated into existing models. We conclude that random permutations are a scalable alternative to circular convolution with several desirable properties.
  •  
3.
  • Recchia, Gabriel L., et al. (författare)
  • Encoding sequential information in semantic space models : Comparing holographic reduced representation and random permutation
  • 2015
  • Ingår i: Computational Intelligence and Neuroscience. - : Hindawi Limited. - 1687-5265 .- 1687-5273. ; 2015
  • Tidskriftsartikel (refereegranskat)abstract
    • Circular convolution and random permutation have each been proposed as neurally plausible binding operators capable of encoding sequential information in semantic memory. We perform several controlled comparisons of circular convolution and random permutation as means of encoding paired associates as well as encoding sequential information. Random permutations outperformed convolution with respect to the number of paired associates that can be reliably stored in a single memory trace. Performance was equal on semantic tasks when using a small corpus, but random permutations were ultimately capable of achieving superior performance due to their higher scalability to large corpora. Finally, "noisy" permutations in which units are mapped to other units arbitrarily (no one-to-one mapping) perform nearly as well as true permutations. These findings increase the neurological plausibility of random permutations and highlight their utility in vector space models of semantics. 
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy