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- Blom Västberg, Oskar, 1987-, et al.
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A dynamic discrete choice activitybased travel demand model
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Other publication (other academic/artistic)abstract
- During the last decades, many activity-based models have been developed in the literature. However, especially in random utility based models timing decisions are often treated poorly or inconsistently with other choice dimensions. In this paper we show how dynamic discrete choice can be used to overcome this problem. In the proposed model, trip decisions are made sequentially in time, starting at home in the morning and ending at home in the evening. At each decision stage, the utility of an alternative is the sum of the one-stage utility of the action and the expected future utility in the reached state.The model generates full daily activity schedules with any number of trips that each is a combination of one of 6 activities, 1240 locations and 4 modes. The ability to go from all to all locations makes evaluating the model very time consuming and sampling of alternatives were therefore used for estimation. The model is estimated on travel diaries and simulation results indicates that it is able to reproduce timing decisions, trip lengths and distribution of the number trips within sample.To explain when people perform different activities, two sets of parameters are used: firstly, the utility of being at home varies depending on the time of day; and secondly, constants determine the utility of arriving to work at specific times. This was enough to also obtain a good distribution of the starting times for free-time activities.
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- Grahn, Oskar, et al.
(author)
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Peritoneal infection after colorectal cancer surgery induces substantial alterations in postoperative protein levels : an exploratory study
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Other publication (other academic/artistic)abstract
- Purpose: Peritoneal infection, due to anastomotic leakage, after resection for colorectal cancer have been shown to associate with increased cancer recurrence and mortality, as well as cardiovascsular morbidity. Alterations in circulating protein levels could help shed light on the underlying mechanisms, prompting this exploratory study of 64 patients operated for colorectal cancer with anastomosis.Methods: Thirty-two cases who suffered a postoperative peritoneal infection were matched with 32 controls who had a complication-free postoperative stay. Proteins in serum samples at their first postoperative visit and at one year after surgery were analysed using proximity extension assays and enzyme-linked immunosorbent assays. Multivariate projection methods, adjusted for multiple testing, were used to compare levels between groups, and enrichment and network analyses were performed.Results: Seventy-seven proteins, out of 270 tested, were differentially expressed at a median sampling time of 41 days after surgery. Many of the differentially expressed top hub proteins have known involvement in cancer progression, survival, invasiveness and metastasis. Over-represented pathways were related to cardiomyopathy, cell-adhesion, extracellular matrix, phosphatidylinositol-3-kinase/Akt (PI3K/Akt) and transforming growth factor beta (TGF-β) signaling.Conclusion: These affected proteins and pathways could provide clues as to why these patients might suffer increased cancer recurrence, mortality and cardiovascular morbidity.
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