| 1. |
- Chroinin, Danielle Ni, et al.
(författare)
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Statin Therapy and Outcome After Ischemic Stroke : Systematic Review and Meta-Analysis of Observational Studies and Randomized Trials
- 2013
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Ingår i: Stroke. - 0039-2499 .- 1524-4628. ; 44:2, s. 448-456
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Forskningsöversikt (refereegranskat)abstract
- Background and Purpose-Although experimental data suggest that statin therapy may improve neurological outcome after acute cerebral ischemia, the results from clinical studies are conflicting. We performed a systematic review and meta-analysis investigating the relationship between statin therapy and outcome after ischemic stroke. Methods-The primary analysis investigated statin therapy at stroke onset (prestroke statin use) and good functional outcome (modified Rankin score 0 to 2) and death. Secondary analyses included the following: (1) acute poststroke statin therapy (<= 72 hours after stroke), and (2) thrombolysis-treated patients. Results-The primary analysis included 113 148 subjects (27 studies). Among observational studies, statin treatment at stroke onset was associated with good functional outcome at 90 days (pooled odds ratio [OR], 1.41; 95% confidence interval [CI], 1.29-1.56; P<0.001), but not 1 year (OR, 1.12; 95% CI, 0.9-1.4; P=0.31), and with reduced fatality at 90 days (pooled OR, 0.71; 95% CI, 0.62-0.82; P<0.001) and 1 year (OR, 0.80;95% CI, 0.67-0.95; P=0.01). In the single randomized controlled trial reporting 90-day functional outcome, statin treatment was associated with good outcome (OR, 1.5; 95% CI, 1.0-2.24; P=0.05). No reduction in fatality was observed on meta-analysis of data from 3 randomized controlled trials (P=0.9). In studies restricted to of thrombolysis-treated patients, an association between statins and increased fatality at 90 days was observed (pooled OR, 1.25; 95% CI, 1.02-1.52; P=0.03, 3 studies, 4339 patients). However, this association was no longer present after adjusting for age and stroke severity in the largest study (adjusted OR, 1.14; 95% CI, 0.90-1.44; 4012 patients). Conclusion-In the largest meta-analysis to date, statin therapy at stroke onset was associated with improved outcome, a finding not observed in studies restricted to thrombolysis-treated patients. Randomized trials of statin therapy in acute ischemic stroke are needed.
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| 2. |
- Joffrin, E., et al.
(författare)
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Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
- 2019
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 59:11
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Forskningsöversikt (refereegranskat)abstract
- For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.
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| 3. |
- Jonsson, Stefan, 1961-
(författare)
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En svart mans anteckningar : (Notes of a Native Son)
- 2021
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Ingår i: Ord och bild. - Göteborg. - 0030-4492 .- 1402-2508. ; :2, s. 115-118
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Forskningsöversikt (övrigt vetenskapligt/konstnärligt)abstract
- Review of new edition in Swedish translation of James Baldwins seminal collection of essays, Notes of a Natiev Son.
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| 4. |
- Jonsson, Stefan, et al.
(författare)
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Normative Barriers to Imitation : Social Complexity of Core Competences in a Mutual Fund Industry
- 2009
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Ingår i: Strategic Management Journal. - : Wiley. - 0143-2095 .- 1097-0266 .- 1932-443X. ; 30:5, s. 517-536
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Forskningsöversikt (refereegranskat)abstract
- Imperfectly imitable resources are central in contemporary analysis of sustainable competitive advantage. While prior work has focused on limitations on the ability to imitate, we argue that it is only a third step in an imitation procedure that also involves the identification of what to imitate and the willingness to imitate. In this study we focus on this last step of unwillingness to imitate due to institutionalized professional norms on product appropriateness. Drawing on institutional theory, we test hypotheses and discuss the complex relationship between institutionalized norms, core competences, and systematic differences in the willingness to imitate.
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| 5. |
- Jonsson, Stefan, et al.
(författare)
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Undeserved Loss : The Spread of Legitimacy Loss to Innocent Organizations in Response to Reported Corporate Deviance
- 2009
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Ingår i: Administrative Science Quarterly. - Ithaca, N.Y. : Graduate School of Business and Public Administration, Cornell University. - 0001-8392 .- 1930-3815. ; 54:2, s. 195-228
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Forskningsöversikt (refereegranskat)abstract
- This paper theorizes about why discoveries of corporate deviance that damage the legitimacy of the responsible organization may also have consequences for other organizations. We propose that audiences generalize from deviance by one organization to others that are similar. The result is a withdrawal from transactions even from non-culpable organizations as audiences seek to avoid organizations that they associate with a deviant act. We show that two scandals involving Skandia AB, a Swedish insurance firm that had a subsidiary offering mutual funds, affected mutual fund providers owned by other insurance firms in 2000--2004, as well as mutual fund subsidiaries of other firms with similar characteristics. The effect was greatest for firms more similar to Skandia and firms owning real estate, which was the context for one of the scandals. Thus audience members' categorization rules lead to spread of legitimacy loss in response to an isolated act of organizational deviance.
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| 6. |
- Ståhl, Stefan, et al.
(författare)
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Affinity proteins and their generation
- 2013
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Ingår i: Journal of chemical technology and biotechnology (1986). - : Wiley. - 0268-2575 .- 1097-4660. ; 88:1, s. 25-38
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Forskningsöversikt (refereegranskat)abstract
- Engineered affinity proteins have, together with antibodies and antibody derivatives, become indispensable tools in many areas of life science and with an increasing number of applications. The need for high-throughput methods for generation of these different affinity proteins is evident. Today, combinatorial protein engineering is the most successful strategy to generate novel affinity proteins of non-immunoglobulin origin. In this approach, high-complexity combinatorial libraries are constructed from which affinity proteins are isolated using appropriate selection methods, thus circumventing the need for detailed knowledge of the protein structure and the binding mechanism that is necessary in more rational approaches. Since the introduction of the phage display technology, several alternative selection systems have been developed for this purpose. This review presents briefly some of the more commonly used affinity proteins, and gives an overview of the different methods and challenges related to the generation of library diversity and the selection methods available for the isolation of affinity proteins with desired properties.
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