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Headache in ADHD as...
Headache in ADHD as comorbidity and a side effect of medications : a systematic review and meta-analysis
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Pan, Pei-Yin (author)
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- Jonsson, Ulf, 1974- (author)
- Karolinska Institutet,Uppsala universitet,Ramklint: Barn- och ungdomspsykiatri,Center of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research; Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden Child and Adolescent Psychiatry, Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden
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Şahpazoğlu Çakmak, Sabriye Selin (author)
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Häge, Alexander (author)
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Hohmann, Sarah (author)
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- Nobel Norrman, Hjalmar (author)
- Karolinska Institutet
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Buitelaar, Jan K. (author)
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Banaschewski, Tobias (author)
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Cortese, Samuele (author)
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Coghill, David (author)
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- Bölte, Sven (author)
- Karolinska Institutet
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(creator_code:org_t)
- Cambridge University Press, 2022
- 2022
- English.
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In: Psychological Medicine. - : Cambridge University Press. - 0033-2917 .- 1469-8978. ; 52:1, s. 14-25
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Abstract
Subject headings
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- There is mixed evidence on the association between headache and attention-deficit/hyperactivity disorder (ADHD), as well as headache and ADHD medications. This systematic review and meta-analysis investigated the co-occurrence of headache in children with ADHD, and the effects of ADHD medications on headache. Embase, Medline and PsycInfo were searched for population-based and clinical studies comparing the prevalence of headache in ADHD and controls through January 26, 2021. In addition, we updated the search of a previous systematic review and network meta-analysis of double-blind randomized controlled trials (RCTs) on ADHD medications on June 16, 2020. Trials of amphetamines, atomoxetine, bupropion, clonidine, guanfacine, methylphenidate, and modafinil with a placebo arm and reporting data on headache as an adverse event, were included. Thirteen epidemiological studies and 58 clinical trials were eligible for inclusion. In epidemiological studies, a significant association between headache and ADHD was found [odds ratio (OR) = 2.01, 95% confidence interval (CI) = 1.63-2.46], which remained significant when limited to studies reporting ORs adjusted for possible confounders. The pooled prevalence of headaches in children with ADHD was 26.6%. In RCTs, three ADHD medications were associated with increased headache during treatment periods, compared to placebo: atomoxetine (OR = 1.29, 95% CI = 1.06-1.56), guanfacine (OR = 1.43, 95% CI = 1.12-1.82), and methylphenidate (OR = 1.33, 95% CI = 1.09-1.63). The summarized evidence suggests that headache is common in children with ADHD, both as part of the clinical presentation as such and as a side effect of some standard medications. Monitoring and clinical management strategies of headache in ADHD, in general, and during pharmacological treatment are recommended.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- ADHD medication
- attention-deficit/hyperactivity disorder
- headache
- meta-analysis
- systematic review
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- ref (subject category)
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- By the author/editor
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Pan, Pei-Yin
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Jonsson, Ulf, 19 ...
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Şahpazoğlu Çakma ...
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Häge, Alexander
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Hohmann, Sarah
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Nobel Norrman, H ...
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show more...
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Buitelaar, Jan K ...
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Banaschewski, To ...
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Cortese, Samuele
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Coghill, David
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Bölte, Sven
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Psychological Me ...
- By the university
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Uppsala University
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Karolinska Institutet