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Accuracy and reliab...
Accuracy and reliability of [C-11]PBR28 specific binding estimated without the use of a reference region
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- Plaven-Sigray, Pontus (författare)
- Karolinska Institutet
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- Schain, Martin (författare)
- Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark.
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- Zanderigo, Francesca (författare)
- Columbia Univ, Dept Psychiat, New York, NY USA.;New York State Psychiat Inst & Hosp, Mol Imaging & Neuropathol Div, New York, NY 10032 USA.
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- Farde, Lars (författare)
- Karolinska Institutet
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- Halldin, Christer (författare)
- Karolinska Institutet
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- Forsberg, Anton (författare)
- Karolinska Institutet
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- Varrone, Andrea (författare)
- Karolinska Institutet
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- Jucaite, Aurelija (författare)
- Karolinska Institutet
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- Cervenka, Simon (författare)
- Karolinska Institutet
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- Stenkrona, Per (författare)
- Karolinska Institutet
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- Collste, Karin (författare)
- Karolinska Institutet
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Kander, Matsle (författare)
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- Kosek, Eva (författare)
- Karolinska Institutet
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- Lampa, Jon (författare)
- Karolinska Institutet
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Hoglund, Caroline Olgart (författare)
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- Rabiner, Eugenii A. (författare)
- Invicro LLC, London, England.
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- Gunn, Roger N. (författare)
- Invicro LLC, London, England.;Imperial Coll London, Div Brain Sci, London, England.
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- Ogden, R. Todd (författare)
- Columbia Univ, Dept Psychiat, New York, NY USA.;New York State Psychiat Inst & Hosp, Mol Imaging & Neuropathol Div, New York, NY 10032 USA.;Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY USA.
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- Cervenk, Simon (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, SE-17176 Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm Cty Council, Stockholm Hlth Care Serv, SE-17176 Stockholm, Sweden.
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Karolinska Institutet Copenhagen Univ Hosp, Neurobiol Res Unit, Copenhagen, Denmark (creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2019
- 2019
- Engelska.
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Ingår i: NeuroImage. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 1053-8119 .- 1095-9572. ; 188, s. 102-110
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- [C-11]PBR28 is a positron emission tomography radioligand used to examine the expression of the 18 kDa translocator protein (TSPO). TSPO is located in glial cells and can function as a marker for immune activation. Since TSPO is expressed throughout the brain, no true reference region exists. For this reason, an arterial input function is required for accurate quantification of [C-11]PBR28 binding and the most common outcome measure is the total distribution volume (V-T). Notably, V-T reflects both specific binding and non-displaceable binding. Therefore, estimates of specific binding, such as binding potential (e.g. BPND) and specific distribution volume (V-S) should theoretically be more sensitive to underlying differences in TSPO expression. It is unknown, however, if unbiased and accurate estimates of these outcome measures are obtainable for [C-11]PBR28. The Simultaneous Estimation (SIME) method uses time-activity-curves from multiple brain regions with the aim to obtain a brain-wide estimate of the non-displaceable distribution volume (V-ND), which can subsequently be used to improve the estimation of BPND and V-S. In this study we evaluated the accuracy of SIME-derived V-ND, and the reliability of resulting estimates of specific binding for [C-11]PBR28, using a combination of simulation experiments and in vivo studies in healthy humans. The simulation experiments, based on data from 54 unique [C-11]PBR28 examinations, showed that V-ND values estimated using SIME were both precise and accurate. Data from a pharmacological competition challenge (n = 5) showed that SIME provided V-ND values that were on average 19% lower than those obtained using the Lassen plot, but similar to values obtained using the Likelihood-Estimation of Occupancy technique. Test-retest data (n = 11) showed that SIME-derived V-S values exhibited good reliability and precision, while larger variability was observed in SIME-derived BPND values. The results support the use of SIME for quantifying specific binding of [C-11]PBR28, and suggest that V-S can be used in complement to the conventional outcome measure V-T. Additional studies in patient cohorts are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Positron emission tomography
- SIME
- [C-11]PBR28
- Translocator protein
- Non-displaceable binding
- Reference region
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Plaven-Sigray, P ...
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Schain, Martin
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Zanderigo, Franc ...
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Farde, Lars
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Halldin, Christe ...
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Forsberg, Anton
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visa fler...
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Varrone, Andrea
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Jucaite, Aurelij ...
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Cervenka, Simon
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Stenkrona, Per
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Collste, Karin
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Kander, Matsle
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Kosek, Eva
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Lampa, Jon
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Hoglund, Carolin ...
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Rabiner, Eugenii ...
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Gunn, Roger N.
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Ogden, R. Todd
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Cervenk, Simon
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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NeuroImage
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet