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- Wang, Yangong, et al.
(författare)
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TEP1 is a risk gene for sporadic cerebral palsy
- 2021
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Ingår i: Journal of genetics and genomics. - : Elsevier BV. - 1673-8527. ; 48:12, s. 1134-1138
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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- Cao, Zi-Jun, et al.
(författare)
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State-of-the-art review of inherent variability and uncertainty in geotechnical properties and models : Chapter 6: Determining characteristic values of geotechnical parameters and resistance: an overview
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- CEN committee TC250 is currently working on an update of the Eurocodes. Subcommittee SC10,in charge of updating EN 1990 (Basis of structural and geotechnical design has installed aworking group to produce a background document with the working title ‘Reliability Backgrounds of the Eurocodes’, with the intention to document and explain the reliability framework underlying all Eurocodes and the implementation of reliability aspects in them. As part of that effort, quantitative information on the inherent variability and uncertainty in loads, material properties and models is compiled. ISSMGE TC304 identified this as an opportunity to provide an overview of the relevant information available in the geotechnical literature such as the statistics of soil/rock properties. The EPRI TR 105000 report (Phoon et al. 1995) provided an overview of the statistics of inherent soil properties and measurement errors, but these statistics have not yet been updated systematically since 1995. Also, rock properties were not covered by the TR 105000 report. Other than soil/rock properties and measurement errors, there are also other important statistics, such as the statistics of transformation uncertainties and model factors.The current technical report has the following features:1. It serves as an update for the TR 105000 report on the statistics of inherent soil properties. Chapter 1 compiles the site specific statistics for univariate soil properties. Chapter 3 compiles the random field parameters (e.g., the scales of fluctuation) for spatial variability of soils. Many of the statistics are new.2. It contains statistics that are not covered by the TR 105000 report. Chapter 1 compiles the site specific statistics for some rock and rock mass properties. Chapter 2 compiles the site specific correlations between soil/rock properties. Chapter 5 compiles the statistics for transformation uncertainties.3. Chapter 4 compiles the statistics of geotechnical design model factors . Chapter 6 reviews methods that determine the characteristic value defined by the Eurocode 7. Chapter 7 reviews some numerical evidences for the worst case scale of fluctuation.
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- Consiglio, Camila, et al.
(författare)
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Immune system adaptation during gender-affirming testosterone treatment
- 2023
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Ingår i: Journal of Reproductive Immunology. - : Elsevier. - 0165-0378 .- 1872-7603. ; 159, s. 29-30
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Biological sex impacts human immune responses, modulating susceptibility and severity to immune-related diseases. Female generally mount more robust immune responses than males, resulting in lower infection severity and greater autoimmunity incidence. Here, we addressed the contribution of testosterone to human immune function by analyzing a cohort of subjects undergoing gender-affirming testosterone treatment. We performed systems-level immunomonitoring through mass cytometry, scRNA and scA-TAC-Sequencing, and proteome profiling of blood samples at baseline and following 3 and 12 months of treatment. Testosterone treatment was associated with a low-grade inflammatory profile, evidenced by upregulation of proinflammatory plasma proteome (e.g., EN-RAGE, OSM, TNF), and induction of an inflammatory transcriptional program associated with NFkB signaling, and TNF signaling. Following testosterone treatment, higher NFkB activity was revealed in CD4 T, CD8 T, and NK cells in scATACseq analyses. Further, testosterone increased monocytic inflammatory responses upon bacterial stimulation in vitro. Although testosterone was associated with this inflammatory profile, it also exerted negative effects on antiviral immunity. Firstly, the percentage of plasmacytoid dendritic cells (pDC) decreased over transition, with pDC also displaying phenotypic changes associated with lower IFN responses. Secondly, bulk transcriptomics analyses show an overall reduction of IFNa responses. Thirdly, testosterone treatment led to reduced IFNa production upon PBMCs stimulation with a viral agonist. Our results show that testosterone has broad effects on the human immune system, and significantly modulates important players in antiviral immunity and inflammatory response. Identifying pathways involved in immune sexual dimorphism will help define novel targets for effective prevention and treatment of immune-mediated diseases.
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