Search: WFRF:(Jurczak Wojciech)
> Wu Chenglin >
Genetic heterogenei...
Genetic heterogeneity in primary and relapsed mantle cell lymphomas : Impact of recurrent CARD11 mutations
-
- Wu, Chenglin (author)
- Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
-
- de Miranda, Noel F. C. C. (author)
- Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
-
- Chen, Longyun (author)
- Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.;Beijing Genom Inst, Shenzhen, Peoples R China.
-
show more...
-
- Wasik, Agata M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Lab Med, Div Pathol, Karolinska Univ Hosp, Stockholm, Sweden.,Jagiellonian Univ, Fac Hlth Sci, Coll Med, Krakow, Poland.
-
- Mansouri, Larry (author)
- Uppsala universitet,Experimentell och klinisk onkologi
-
- Jurczak, Wojciech (author)
- Jagiellonian Univ, Dept Hematol, Coll Med, Krakow, Poland.
-
- Galazka, Krystyna (author)
- Jagiellonian Univ, Dept Pathol, Coll Med, Krakow, Poland.
-
- Dlugosz-Danecka, Monika (author)
- Jagiellonian Univ, Dept Hematol, Coll Med, Krakow, Poland.
-
- Machaczka, Maciej (author)
- Jagiellonian Univ, Fac Hlth Sci, Coll Med, Krakow, Poland.
-
- Zhang, Huilai (author)
- Tianjin Med Univ, Dept Lymphoma, Canc Hosp & Inst, Tianjin, Peoples R China.
-
- Peng, Roujun (author)
- Sun Yat Sen Univ, Dept Med Oncol, Collaborat Innovat Ctr Canc Med, Canc Ctr,State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China.
-
- Morin, Ryan D. (author)
- Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada.
-
- Rosenquist, Richard (author)
- Uppsala universitet,Experimentell och klinisk onkologi
-
- Sander, Birgitta (author)
- Karolinska Institutet,Karolinska Inst, Dept Lab Med, Div Pathol, Karolinska Univ Hosp, Stockholm, Sweden.
-
- Pan-Hammarstrom, Qiang (author)
- Karolinska Institutet,Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.
-
show less...
-
Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden Karolinska Inst, Karolinska Univ Hosp, Div Clin Immunol & Transfus Med, Stockholm, Sweden.;Beijing Genom Inst, Shenzhen, Peoples R China. (creator_code:org_t)
- 2016-05-20
- 2016
- English.
-
In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:25, s. 38180-38190
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- The genetic mechanisms underlying disease progression, relapse and therapy resistance in mantle cell lymphoma (MCL) remain largely unknown. Whole-exome sequencing was performed in 27 MCL samples from 13 patients, representing the largest analyzed series of consecutive biopsies obtained at diagnosis and/or relapse for this type of lymphoma. Eighteen genes were found to be recurrently mutated in these samples, including known (ATM, MEF2B and MLL2) and novel mutation targets (S1PR1 and CARD11). CARD11, a scaffold protein required for B-cell receptor (BCR)-induced NF-kappa B activation, was subsequently screened in an additional 173 MCL samples and mutations were observed in 5.5% of cases. Based on in vitro cell line-based experiments, overexpression of CARD11 mutants were demonstrated to confer resistance to the BCR-inhibitor ibrutinib and NF-kappa B-inhibitor lenalidomide. Genetic alterations acquired in the relapse samples were found to be largely non-recurrent, in line with the branched evolutionary pattern of clonal evolution observed in most cases. In summary, this study highlights the genetic heterogeneity in MCL, in particular at relapse, and provides for the first time genetic evidence of BCR/NF-kappa B activation in a subset of MCL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- whole-exome sequencing
- mantle cell lymphoma
- relapse
- CARD11
- NF-kappa B inhibitor
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Oncotarget
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Wu, Chenglin
-
de Miranda, Noel ...
-
Chen, Longyun
-
Wasik, Agata M.
-
Mansouri, Larry
-
Jurczak, Wojciec ...
-
show more...
-
Galazka, Krystyn ...
-
Dlugosz-Danecka, ...
-
Machaczka, Macie ...
-
Zhang, Huilai
-
Peng, Roujun
-
Morin, Ryan D.
-
Rosenquist, Rich ...
-
Sander, Birgitta
-
Pan-Hammarstrom, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Oncotarget
- By the university
-
Uppsala University
-
Karolinska Institutet