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Träfflista för sökning "WFRF:(Kaartinen Niina) ;spr:eng"

Sökning: WFRF:(Kaartinen Niina) > Engelska

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1.
  • Schumann, Gunter, et al. (författare)
  • KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference
  • 2016
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 113:50, s. 14372-14377
  • Tidskriftsartikel (refereegranskat)abstract
    • Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified beta-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 x 10(-12)). beta-Klotho is an obligate coreceptor for the hormone FGF21, which is secreted from the liver and implicated in macronutrient preference in humans. We show that brain-specific beta-Klotho KO mice have an increased alcohol preference and that FGF21 inhibits alcohol drinking by acting on the brain. These data suggest that a liver-brain endocrine axis may play an important role in the regulation of alcohol drinking behavior and provide a unique pharmacologic target for reducing alcohol consumption.
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2.
  • Wennberg, Maria, 1974-, et al. (författare)
  • Dietary transition
  • 2021. - 1
  • Ingår i: Amap assesment 2021. - Tromsö : AMAP. - 9788279712008 ; , s. 13-46
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
    • Key findings:Most Arctic populations have experienced a transition towards more imported foods. The dietary transition has had adverse impacts on health in some populations, such as an increase in obesity or impaired dental status. Intakes of vitamin D and iodine have decreased due to lower fish and/or milk consumption. These nutrients should be monitored in Arctic populations. Positive health impacts of the dietary transition include significantly reduced levels of contaminants in the blood of pregnant women. Whether dietary transition is negative or positive for health depends on the composition of the new diet, as well as the extent to which the traditional diet is maintained. Communication about dietary risks and benefits is vital. Food insecurity is a growing concern in some Arctic populations and collaboration between countries should be established to address this. There are gaps in the research field of dietary studies within Arctic Indigenous populations. More studies are needed, especially within the many Arctic populations in Russia
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