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Gene expression acr...
Gene expression across mammalian organ development
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- Cardoso-Moreira, Margarida (author)
- Heidelberg Univ ZMBH, Germany; Univ Lausanne, Switzerland
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- Halbert, Jean (author)
- Univ Lausanne, Switzerland
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- Valloton, Delphine (author)
- Univ Lausanne, Switzerland
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- Velten, Britta (author)
- European Mol Biol Lab, Germany
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- Chen, Chunyan (author)
- Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
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- Shao, Yi (author)
- Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
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- Liechti, Angelica (author)
- Univ Lausanne, Switzerland
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- Ascencao, Kelly (author)
- Univ Lausanne, Switzerland
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- Rummel, Coralie (author)
- Univ Lausanne, Switzerland
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- Ovchinnikova, Svetlana (author)
- Heidelberg Univ ZMBH, Germany
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- Mazin, Pavel V. (author)
- Skolkovo Inst Sci and Technol, Russia; RAS, Russia; HSE Univ, Russia
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- Xenarios, Ioannis (author)
- Univ Lausanne, Switzerland
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- Harshman, Keith (author)
- Univ Lausanne, Switzerland
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- Mort, Matthew (author)
- Cardiff Univ, Wales
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- Cooper, David N. (author)
- Cardiff Univ, Wales
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- Sandi, Carmen (author)
- Ecole Polytech Fed Lausanne, Switzerland
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- Soares, Michael J. (author)
- Univ Kansas, MO USA; Childrens Mercy, MO USA
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- Ferreira, Paula G. (author)
- Univ Porto, Portugal; Univ Porto, Portugal
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- Afonso, Sandra (author)
- Univ Porto, Portugal
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- Carneiro, Miguel (author)
- Univ Porto, Portugal; Univ Porto, Portugal
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- Turner, James M. A. (author)
- Francis Crick Inst, England
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- VandeBerg, John L. (author)
- Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA; Univ Texas Rio Grande Valley, TX USA
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- Fallahshahroudi, Amir (author)
- Linköpings universitet,Biologi,Tekniska fakulteten
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- Jensen, Per (author)
- Linköpings universitet,Biologi,Tekniska fakulteten
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- Behr, Ruediger (author)
- Leibniz Inst Primate Res DPZ, Germany; DZHK German Ctr Cardiovasc Res, Germany
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- Lisgo, Steven (author)
- Newcastle Univ, England
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- Lindsay, Susan (author)
- Newcastle Univ, England
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- Khaitovich, Philipp (author)
- Skolkovo Inst Sci and Technol, Russia; Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
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- Huber, Wolfgang (author)
- European Mol Biol Lab, Germany
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- Baker, Julie (author)
- Stanford Univ, CA 94305 USA
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- Anders, Simon (author)
- Heidelberg Univ ZMBH, Germany
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- Zhang, Yong E. (author)
- Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China; Chinese Acad Sci, Peoples R China
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- Kaessmann, Henrik (author)
- Heidelberg Univ ZMBH, Germany
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(creator_code:org_t)
- 2019-06-26
- 2019
- English.
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In: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 571:7766, s. 505-
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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- By the author/editor
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Cardoso-Moreira, ...
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Halbert, Jean
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Valloton, Delphi ...
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Velten, Britta
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Chen, Chunyan
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Shao, Yi
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show more...
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Liechti, Angelic ...
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Ascencao, Kelly
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Rummel, Coralie
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Ovchinnikova, Sv ...
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Mazin, Pavel V.
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Xenarios, Ioanni ...
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Harshman, Keith
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Mort, Matthew
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Cooper, David N.
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Sandi, Carmen
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Soares, Michael ...
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Ferreira, Paula ...
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Afonso, Sandra
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Carneiro, Miguel
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Turner, James M. ...
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VandeBerg, John ...
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Fallahshahroudi, ...
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Jensen, Per
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Behr, Ruediger
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Lisgo, Steven
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Lindsay, Susan
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Khaitovich, Phil ...
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Huber, Wolfgang
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Baker, Julie
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Anders, Simon
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Zhang, Yong E.
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Kaessmann, Henri ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature
- By the university
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Linköping University