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Local release of ma...
Local release of magnesium from mesoporous TiO2 coatings stimulates the peri-implant expression of osteogenic markers and improves osteoconductivity in vivo
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- Galli, Silvia (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Naito, Yoshihito (author)
- Malmö högskola,Odontologiska fakulteten (OD),Tokushima University Hospital
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- Karlsson, Johan, 1984 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- He, Wenxiao, 1985 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Miyamoto, Ikuya (author)
- Kyushu University
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- Xue, Ying (author)
- Universitetet i Bergen,University of Bergen
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- Andersson, Martin, 1974 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Mustafa, Kamal (author)
- Universitetet i Bergen,University of Bergen
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- Wennerberg, Ann (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Jimbo, Ryo (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university,Nagasaki University
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(creator_code:org_t)
- Elsevier, 2014
- 2014
- English.
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In: Acta Biomaterialia. - : Elsevier. - 1742-7061 .- 1878-7568. ; 10:12, s. 5193-5201
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Local release of Mg ions from titanium implant surfaces has been shown to enhance implant retention and integration. To clarify the biological events that lead to this positive outcome, threaded implants coated with mesoporous TiO2 thin films were loaded with Mg-ions and placed in the tibia of rabbits for 3 weeks, after surface characterization. Non-loaded mesoporous coated implants were used as controls. Peri-implant gene expression of a set of osteogenic and inflammatory assays was quantified by means of real-time quantitative polymerase chain reaction. The expression of three osteogenic markers (OC, RUNX-2 and IGF-1) was significantly more pronounced in the test specimens, suggesting that the release of Mg ions directly at the implant sites may stimulate an osteogenic environment. Furthermore, bone healing around implants was evaluated on histological slides and by diffraction-enhanced imaging (DEI), using synchrotron radiation. The histological analysis demonstrated new bone formation around all implants, without negative responses, with a significant increase in the number of threads filled with new bone for test surfaces. DEI analysis attested the high mineral content of the newly formed bone. Improved surface osteoconductivity and increased expression of genes involved in the bone regeneration were found for magnesium-incorporation of mesoporous TiO2 coatings.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- Magnesium
- Local drug delivery osseointegration
- Nanotopography
- Diffraction-enhanced imaging
- Gene expression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Galli, Silvia
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Naito, Yoshihito
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Karlsson, Johan, ...
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He, Wenxiao, 198 ...
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Miyamoto, Ikuya
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Xue, Ying
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show more...
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Andersson, Marti ...
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Mustafa, Kamal
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Wennerberg, Ann
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Jimbo, Ryo
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Material ...
- Articles in the publication
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Acta Biomaterial ...
- By the university
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Malmö University
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Chalmers University of Technology