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- Gennser, Mikael, et al.
(författare)
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Effects of dietary lipids on frequency and force in atrial muscle at 10 MPa
- 1987
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Ingår i: Undersea biomedical research. - 0093-5387. ; 14:1, s. 31-43
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Tidskriftsartikel (refereegranskat)abstract
- Spontaneously beating atrial preparations, from rats fed different lipid diets, were compressed to 10 MPa. The following observations were made: Different lipid diets altered the ratio of omega-6/omega-3 polyunsaturated fatty acids of the cardiac phospholipids. Beating frequency and twitch tension at surface pressure was unaffected by the diets. Compression to 10 MPa caused a decrease in spontaneous beating frequency and an increased twitch tension in all preparations. The decrease in beating frequency was inversely related to the omega-6/omega-3 ratio. Pressure induced increase in twitch tension was not affected by the diets. N2O dissolved in the tissue bath solution partly counteracted the pressure-induced changes.
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