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- Jung, Sung-jun, et al.
(författare)
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The Sec62/63 translocon facilitates membrane insertion and C-terminal translocation of multi-spanning membrane proteins
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Majority of membrane proteins are co-translationally translocated. The Sec62/Sec63 complex which mediates post-translational translocation of a subset of primarily secretory proteins into the endoplasmic reticulum (ER), therefore has been thought uninvolved in targeting and translocation of membrane proteins. By systematic analysis of single and multi-spanning membrane proteins with broad sequence context; varying hydrophobicity, flanking charged residues and orientation of transmembrane (TM) segments, in a set of Sec62 mutant yeast strains, we show that mutations in the N-terminal cytosolic domain of Sec62 impair interaction with Sec63 and lead to defects in membrane insertion and the C-terminal translocation of membrane proteins. These results reveal an unappreciated function of the Sec62/Sec63 translocon as a general membrane chaperone that regulates topogenesis of membrane proteins in the eukaryotic cell.
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| 3. |
- Lochner, Michelle, et al.
(författare)
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Optimizing the LSST Observing Strategy for Dark Energy Science : DESC Recommendations for the Wide-Fast-Deep Survey
- 2018
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Cosmology is one of the four science pillars of LSST, which promises to be transformative for our understanding of dark energy and dark matter. The LSST Dark Energy Science Collaboration (DESC) has been tasked with deriving constraints on cosmological parameters from LSST data. Each of the cosmological probes for LSST is heavily impacted by the choice of observing strategy. This white paper is written by the LSST DESC Observing Strategy Task Force (OSTF), which represents the entire collaboration, and aims to make recommendations on observing strategy that will benefit all cosmological analyses with LSST. It is accompanied by the DESC DDF (Deep Drilling Fields) white paper (Scolnic et al.). We use a variety of metrics to understand the effects of the observing strategy on measurements of weak lensing, large-scale structure, clusters, photometric redshifts, supernovae, strong lensing and kilonovae. In order to reduce systematic uncertainties, we conclude that the current baseline observing strategy needs to be significantly modified to result in the best possible cosmological constraints. We provide some key recommendations: moving the WFD (Wide-Fast-Deep) footprint to avoid regions of high extinction, taking visit pairs in different filters, changing the 2x15s snaps to a single exposure to improve efficiency, focusing on strategies that reduce long gaps (>15 days) between observations, and prioritizing spatial uniformity at several intervals during the 10-year survey.
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| 4. |
- Papawassiliou, Wassilios, 1991-, et al.
(författare)
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Emergent Weyl Fermions and the Metal to Weyl-Semimetal phase transition in WTe2,via broadband High Resolution NMR
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Weyl Fermions (WFs) in the type-II Weyl Semimetal (WSM) WTe2 are difficult to resolve experimentally because the Weyl bands disperse in an extremely narrow region of the (E-k) space. Here, by using DFT-assisted high-resolution 125Te solid-state NMR (ssNMR) in the temperature range 50K - 700K, we succeeded in detecting low energy WF excitations and monitor their evolution with temperature. Remarkably, WFs appear to emerge at T∼120K; at lower temperatures WTe2 behaves as a metal. This intriguing metal-to-WSM phase transition is shown to be induced by the rapid raise of the Fermi level with temperature, crossing solely the electron and hole pockets in the low-T metallic phase, while crossing the Weyl bands near the nodal points - a prerequisite for the emergence of WFs - only for T>120K.
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| 7. |
- Rantzer, Annika, et al.
(författare)
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Sputter-deposited a-Si:H for p-i-n photodiodes
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- DC magnetron sputter deposition is explored as an alternative for fabricating vertically integrated sensor systems in the form of p-i-n diodes of hydrogenated amorphous silican deposited on CMOS integrated circuit substrates in a post-processing step. We focus here on dopant oncorporation and surface morphological evolution during synthesis of the p-i-n diode sensor structures. The Doping was accomplished using doped targets in a mixed H2/Ar environment. Incorporated P concetrations range from 2.62 to 4.8 x 1019 cm-3 with corresponding conductivities, σ, up to 1.4 x10-5 ohm-1cm-1. B contentrations are between 2.79 and 6.7 X 1020 cm-3 with σ = 4 x 10-5 to 4 x 10-2 ohm-1cm-1. The results of the dopant incorporation are in agreement with reported molecular dynamics simulations. The best intrinsic films have a light to dark conductivity ratio of 102 for white light at an intensity of 10 W/m2. The dark conductivity is a 8 x 10-9 ohm-1cm-1. We conclude that dc magnetron sputter deposition is a good candidate for future device fabrication.
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| 8. |
- Öresland, Stina, et al.
(författare)
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Nurses go visiting
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Annan publikation (övrigt vetenskapligt/konstnärligt)
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