| 1. |
- Duggan, D., et al.
(författare)
-
Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP
- 2007
-
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press (OUP). - 0027-8874 .- 1460-2105. ; 99:24, s. 1836-1844
-
Tidskriftsartikel (refereegranskat)abstract
- Background: The consistent finding of a genetic susceptibility to prostate cancer suggests that there are germline sequence variants predisposing individuals to this disease. These variants could be useful in screening and treatment. Methods: We performed an exploratory genome-wide association scan in 498 men with aggressive prostate cancer and 494 control subjects selected from a population-based case-control study in Sweden. We combined the results of this scan with those for aggressive prostate cancer from the publicly available Cancer Genetic Markers of Susceptibility (CGEMS) Study. Single-nucleotide polymorphisms (SNPs) that showed statistically significant associations with the risk of aggressive prostate cancer based on two-sided allele tests were tested for their association with aggressive prostate cancer in two independent study populations composed of individuals of European or African American descent using one-sided tests and the genetic model (dominant or additive) associated with the lowest value in the exploratory study. Results: Among the approximately 60000 SNPs that were common to our study and CGEMS, we identified seven that had a similar (positive or negative) and statistically significant (P<.01) association with the risk of aggressive prostate cancer in both studies. Analysis of the distribution of these SNPs among 1032 prostate cancer patients and 571 control subjects of European descent indicated that one, rs1571801, located in the DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, was associated with aggressive prostate cancer (one-sided P value =. 004). The association was also statistically significant in an African American study population that included 210 prostate cancer patients and 346 control subjects (one-sided P value =. 02). Conclusion: A genetic variant in DAB2IP may be associated with the risk of aggressive prostate cancer and should be evaluated further.
|
|
| 2. |
- Campana, Pietro Elia, et al.
(författare)
-
Suitable and optimal locations for implementing photovoltaic water pumping systems for grassland irrigation in China
- 2017
-
Ingår i: APPLIED ENERGY. - : Elsevier BV. - 0306-2619 .- 1872-9118. ; 185, s. 1879-1889
-
Tidskriftsartikel (refereegranskat)abstract
- Grassland plays a key role for the food security of China because of the large number of livestock raised in those areas. Thus, grassland degradation due to climate change and overgrazing is considered as one of the most severe environmental and economic threat for the future sustainable development of China. Photovoltaic water pumping systems for irrigation can play a fundamental role for the conservation of grassland areas. This paper investigates the geospatial distribution of the technically suitable grassland locations for the implementation of photovoltaic water pumping systems. The technically suitable grassland areas were taken as starting point to assess the optimal locations. The assessment of the optimal locations was conducted using a spatially explicit optimization model of renewable energy systems based on the cost minimization of the whole forage supply chain. The results indicate that the photovoltaic water pumping systems provide high potential for improving forage productivity, contributing to meet the local demand. The optimal areas are highly sensitive to several environmental and economic parameters such as increased forage potential yield, forage management costs, forage water requirements, ground water depth, forage price and CO2 price. Most of the optimal areas are selected when the market forage price ranges from 300 to 500 $/tonne DM, indicating that the forage produced using PVWP technology for irrigation is already competitive compared to the imported forage.
|
|
| 3. |
|
|
| 4. |
- Shrestha, Rakesh, et al.
(författare)
-
Adaptive software platform architecture for aerial vehicle safety levels in real-world applications
- 2023
-
Ingår i: Advances in Computers. - : Academic Press Inc.. - 0065-2458.
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Urban cities have congested with vehicles, resulting in traffic jams, and a lot of time and energy will be wasted while traveling. In the near future, low-altitude aerial vehicles are expected to be implemented for air traffic as a resolution to overcome these issues. Due to the threats to commercial aircraft as well as danger to the public and objects on the ground, these low-altitude aerial vehicles should exhibit an equivalent level of safety similar to commercial aircraft. We propose a new safety level for low-altitude electric propeller-based compact aerial vehicles. The safety level of Aerial Vehicles is based on the concept of civil aviation safety levels and automotive safety levels, and we incorporate the appropriate safety characteristics from both automotive safety integrity levels and aviation safety levels. We also discussed adjusting the aerial vehicle safety levels with NASA's Technical Capability Levels (TCL), which helps design an Electrical and Electronics (E/E) architecture for the aerial vehicles. We presented a new conceptual E/E architecture for the aerial vehicles based on adjusted technical capabilities levels and aerial vehicle safety levels to provide functional safety for the aerial vehicle. We also discuss the adaptive software platform based on virtualization, which partitions the time-critical operating system of aerial vehicles to host several applications of different software levels on the same hardware.
|
|
