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Sökning: WFRF:(Kim Youngwook)

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1.
  • Yuan, Yuan, et al. (författare)
  • Comprehensive molecular characterization of mitochondrial genomes in human cancers
  • 2020
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 52:3, s. 342-352
  • Tidskriftsartikel (refereegranskat)abstract
    • Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. Our analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases. Truncating mutations are markedly enriched in kidney, colorectal and thyroid cancers, suggesting oncogenic effects with the activation of signaling pathways. We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. Mitochondrial copy number varies greatly within and across cancers and correlates with clinical variables. Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. Our study lays a foundation for translating mitochondrial biology into clinical applications.
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2.
  • Lee, S.H., et al. (författare)
  • Activity of Sulfate Reducing Bacteria in Successive Alkalinity Producing System: Part I- Effect of Temperature
  • 2010
  • Ingår i: Research Journal of Chemistry and Environment. - 0972-0626. ; 14:4, s. 67-73
  • Tidskriftsartikel (refereegranskat)abstract
    • Successive alkalinity producing system (SAPS) is one of the most preferred passive treatment system for acid mine drainage. Sulfate reducing bacteria (SRB) in SAPS make anaerobic environment needed to successive alkalinity production of limestone. It was observed that the SRB activity was most apparent at 36 oC and sulfate removal rate of up to 86% was achieved at this temperature when SAPS had 8 cm thickness of mushroom compost layer and hydraulic retention time (HRT) of 8 days. The sulfate removal rate was directly proportional to the temperature and it significantly decreased at 1 oC. The unexpected observation on the increased effluent sulfate concentration at 1 oC was due to the effect of sulfate elution from the mushroom compost. Iron removal rate was governed by both temperature and thickness of the mushroom compost layer. Finally, cultivation experiments revealed that SRB growth was significantly influenced by the temperature. The results of the present study suggest that the temperature directly influences on the SRB growth and subsequently controls the treatment efficiency of SAPS.
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